PubMed Health⌕ Search

Biomedical subjects

A Korner

Publications and source records attributed to A Korner.

At least 19 recordsLinked to original sources
PubMed2000

Liveliness.

OBJECTIVE: The objective of this study is to explore the significance of the experience of liveliness in psychotherapeutic interactions and its relevance to the practice of psychotherapy. METHOD: Stern's notion of 'vitality affects' and Emde's concept of a 'primary affective core' are employed in developing a concept of liveliness, or an enlivening-deadening axis of experience. A critique of Freud's 'principles of mental functioning' is made in the light of this concept. Clinical examples are provided as illustrations of the relevance of considering the 'sense of liveliness', and its sustainability, in psychotherapy. RESULTS AND CONCLUSIONS: A sense of liveliness relates closely to activity within a system of interpersonal resonance with non-linear characteristics. The experience of, and responses to, vitality affects may be an important basis of a sense of liveliness. Sudden shifts towards experiences of deadness are a matter for concern in psychotherapy. This sphere of experience, although occurring largely outside verbal awareness, may constitute a distinct type of mental process. Three types of mental activity or process are postulated: (i) emergent, pre-representational activity characterised by the sense of liveliness; (ii) Play-related thought or activity typically experienced as enlivening; and (iii) work-related or adaptational thought or activity.

Affect↗
PubMed1998

(You gotta have) faith.

OBJECTIVE: The modern scientific tendency to disavow the relevance of faith is questioned, particularly in relation to psychiatric practice. An experience-near approach to psychiatric practice, inclusive of human values such as faith, is highlighted. METHOD: Drawing upon the philosophical work of Jaspers and the developmental psychology of Stern, a model is built up of the flow of lived experience that relies to a large extent on what can be 'taken on faith' rather than 'known about'. An argument is presented that from this standpoint of 'lived reality', the separation of fact and value inherent in modern scientific thought is not valid. CONCLUSIONS: It is found that lived experience is infused with faith in three senses: that of faith-in-oneself, that of faith-in-the-other; and that of transcendent faith. Each of these is shown to be relevant to praxis in psychiatry. Failure to include faith in psychiatric thinking may lead to a distancing of the discipline from the level of everyday experience.

Humans↗
PubMed1993

Organization of sleep-waking states in conjoined twin neonates.

Developmentally normal twins, joined from the mid-sternum to the umbilicus in a face-to-face position, were observed in 90-minute sessions twice daily from postnatal days 12 to 16. Sleep-waking states were coded in 10-second epochs. Within-twin data were analyzed for bout lengths, interbout intervals, transition probabilities and 60-minute autocorrelation patterns. Between-twin data were studied for simultaneous occurrences of sleep-waking states and 60-minute cross-correlation patterns. Epochs per bout and interbout intervals for quiet and active sleep, active sleep epochs with rapid eye movements (REMs) and quiet and active waking states showed little difference between the twins over the study days. Probabilities of transition between quiet and active sleep and active wakefulness also showed the same patterns for each twin. However, the organization of temporal states differed markedly. Simultaneous occurrences of the same states were at or barely above chance levels, autocorrelation patterns of all states except epochs with REMs were not the same and cross-correlations indicated little influence of one twin's current state on the subsequent probability of that state's occurrence in the other twin. Thus, neither shared environment, identical genotype nor shared stimulation from co-twin motor activity appeared to synchronize the temporal organization of behavioral states in these twins. We concluded that the overall distributions of neonatal sleep-waking states seem to be determined primarily by age, whereas the temporal organization of states expresses the neonate's individuality.

Apgar Score↗
PubMed1989

Change of serum inorganic phosphate complexes in diabetic ketoacidosis.

The concentrations of serum inorganic phosphate complexes (HPO4(2-), H2PO4-, NaHPO4-, KHPO4-, CaHPO4 and MgHPO4) were studied during diabetic ketoacidosis. On admission to hospital the H2PO4- concentration was significantly increased, in comparison with well-controlled diabetics. After 12-24 h the concentration of all phosphate complexes decreased. At 72 h only the MgHPO4 concentration was decreased. These changes are related to acidosis, insulin therapy and tubular dysfunction.

Adolescent↗
PubMed1972

A decreased aminoacyl-transfer-ribonucleic acid-binding capacity of 40S ribosomal subunits resulting from hypophysectomy of the rat.

A technique that permitted the reversible dissociation of rat liver ribosomes was used to study the difference in protein-synthetic activity between liver ribosomes of normal and hypophysectomized rats. Ribosomal subunits of sedimentation coefficients 38S and 58S were produced from ferritin-free ribosomes by treatment with 0.8m-KCl at 30 degrees C. These recombined to give 76S monomers, which were as active as untreated ribosomes in incorporating phenylalanine in the presence of poly(U). Subunits from normal and hypophysectomized rats were recombined in all possible combinations and the ability of the hybrid ribosomes to catalyse polyphenylalanine synthesis was measured. The results show that the defect in ribosomes of hypophysectomized rats lies only in the small ribosomal subunit. The 40S but not the 60S subunit of rat liver ribosomes bound poly(U). The only requirement for the reaction was Mg(2+), the optimum concentration of which was 5mm. No apparent difference was seen between the poly(U)-binding abilities of 40S ribosomal subunits from normal or hypophysectomized rats. Phenylalanyl-tRNA was bound by 40S ribosomal subunits in the presence of poly(U) by either enzymic or non-enzymic reactions. Non-enzymic binding required a Mg(2+) concentration in excess of 5mm and increased linearly with increasing Mg(2+) concentrations up to 20mm. At a Mg(2+) concentration of 5mm, GTP and either a 40-70%-saturated-(NH(4))(2)SO(4) fraction of pH5.2 supernatant or partially purified aminotransferase I was necessary for binding of aminoacyl-tRNA. Hypophysectomy of rats resulted in a decreased binding of aminoacyl-tRNA by 40S ribosomal subunits.

Amino Acids↗
PubMed1972

Differential inhibition of mammalian ribonucleic acid polymerases by an exotoxin from Bacillus thuringiensis. The direct observation of nucleoplasmic ribonucleic acid polymerase activity in intact nuclei.

The effects of the exotoxin from Bacillus thuringiensis on DNA-dependent RNA polymerases from rat liver were examined. The exotoxin inhibits all RNA polymerase activity at both low and high ionic strength in intact nuclei, and soluble enzymes are similarly affected. This inhibition is relieved by ATP. Dephosphorylated exotoxin did not inhibit the soluble enzymes. Nucleolar and nucleoplasmic RNA polymerases respond to different concentration ranges of exotoxin, and the compound can be used in intact nuclei to isolate the nucleoplasmic activity.

Adenosine Triphosphate↗