PubMed Health⌕ Search

Biomedical subjects

A Kosaka

Publications and source records attributed to A Kosaka.

77 records · Page 5Linked to original sources
PubMedDate not supplied

Galactose-containing amphiphiles prepared with a lipophilic radical initiator.

Novel amphiphiles which contain galactose residues (degree of polymerization (DP) = 6.2, 10, and 15) were prepared by telomerization of 2-[(methacryloyloxy)ethyl]-beta-D-galactopyranoside using a lipophilic radical initiator. The galactose-carrying amphiphile incorporated in a liposome was recognized by a lectin from Ricinus communis (RCA120), which was proven by the increase in turbidity of the liposome suspension after mixing with the lectin. The recognition was largely affected by the degree of polymerization and the surface density of the amphiphile. The amphiphile would be useful as a component of the drug delivery system to hepatocytes.

Drug Carriers↗
PubMedDate not supplied

Galactose-containing amphiphiles prepared with a lipophilic radical initiator: association processes between liposomes triggered by enzymatic reaction.

A galactose-containing monomer (2-(methacryloyloxy)ethyl beta-D-galactopyranoside, MEGal) was polymerized by using a lipophilic radical initiator. The amphiphile obtained formed a liposome by mixing with bis(trans,trans-2,4-dioctadecadienoyl)phosphatidylcholine (DDPC), and the liposome obtained was physically stabilized by the polymerization of DDPC by UV irradiation. The enzymatic treatment of the galactose-containing liposomes with galactose oxidase resulted in the formation of aldehyde groups on the liposome surface. By the subsequent mixing of the liposome suspension with the amino group-containing liposome suspension, a rapid increase in turbidity was observed due to the formation of Schiff bases between the aldehyde groups and the amino groups at the interface of the liposomes. The rate of turbidity change strongly depended on the degree of polymerization of MEGal, the surface densities of galactose and amino groups on the liposome, the distance from the liposome surface to amino end groups, and the flexibility and deformability of the liposomes.

1,2-Dipalmitoylphosphatidylcholine↗