Biomedical subjects
Publications and source records attributed to A Kosatík.
Three cases of disturbed cerebrospinal fluid circulation with the resulting picture of a hydrocephalus, treated by surgery, are described. The operations performed were modified Spitz-Holter twice and Torkildsen's shunt operation once. Both the modifications are described in brief. Two of the cases were suicides, the third perhaps an accidental drowning.
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In 5 substances from the group of non-barbiturate hypnotics (methaqualone, nitrazepam) and psychopharmaceutical preparations (thioridazine, dosulepin, imipramine) the author selected for quantitative high performance thin-layer chromatography a method of direct densitometry, i.e. assessment of absorption in visible light after colour detection by the transmission technique. The assembled results are evaluated by statistical methods. By suitable adjustment of the chromatographic separation and of the parameters of measurement during densitometry in each investigated substance a correlation coefficient r better than 0.997 and a variation coefficient V lower than 10% can be obtained.
An occasional fatal intoxication of Ioxynil is reported. Relevant autopsy findings are given and an extraction procedure for the determination of Ixoynil in the taken in fluid and in autopsy material is described. In the unknown fluid Ioxynil has been identified by using IR and NMR spectroscopy and determined by UV spectrophotometry. In biological material Ioxynil has been identified by TLC and IR spectroscopy. For the determination of blood serum, TLC-densitometry in situ has been carried out.
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The authors describe in their work methods of isolation of organophosphate insecticides from biological material--the isolation of the effective substance proper as well as of the solvent. They detect organophosphates by means of chromatography on a thin leyer and in one instance also by gas chromatography. In conjunction with chromatography on a thin leyer they discuss methods of detection according to the chemical structure of the substances searched for and submit their own modification of detection based on inhibition of acetylcholine esterase. They detect the solvent in insecticides in biological materials by means of gas chromatography.