[Therapeutic efficacy of iodine 131 in autonomous thyroid adenomas--59 cases].
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Biomedical subjects
Publications and source records attributed to A Kraiem.
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Our study dealt with 81 patients treated by iodine 131 for autonomous goiter. We have followed 59 patients during about a year. The global therapeutic efficiency is of 73% and the risk of hypothyroidism is very weak. The administration of a high activity (greater than 15 mCi) of iodine allows to get a faster recovery, a better therapeutic efficiency and permits to reduce the number of cures (therefore, to reduce the irradiation of the patient), nevertheless, the risk of hypothyroidism is very slight. The advantages of metabolic radiotherapy (low cost, facility of administration, efficiency) make it preferable to surgery, above all with patients that are more than 40 years old, for whom the radiation risk is practically null (hereditary diseases, cancer).
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A rigidity index (RI) related to red blood cell deformability was measured by using the hemorheometre. The RI for 13 patients homozygous for sickle cell disease was 109 +/- 44 at 37 degrees C and at atmospheric pO2. The filtration time curve as a function of pO2 is biphasic for sickle cell suspensions. The pO2 at which filtration time is maximum, pO2max., correlated with the rigidity index measured at atmospheric pO2. This pO2max. value was very sensitive to small changes in physico-chemical parameters such as osmolality, pH, temperature, hematocrit, and cell density. Conditions which reduced the Hb S polymerization induced a leftward shift of pO2max.. The experimental curves are in agreement with theoretical models based on the presence of two abnormal cell types: filtrable "slow cells" and infiltrable "sickled cells".
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