The effect of 1-anilinonaphthalene-8-sulfonate (ANS) on the thermotropic phase transition of dipalmitoylphosphatidylcholine (DPPC) bilayers was examined by differential scanning calorimetry. The main phase transition temperature was found to be shifted to lower values in the presence of the probe. The shift strongly depends on pH and the presence of salts. This indicates that the penetration of the probe of the hydrocarbon moiety of the bilayer is influenced by coulombic interactions. Pretransition phenomena are also affected. The implications for the interpretation of experimental data of biomembrane studies are discussed.

Anilino Naphthalenesulfonates↗

PubMedDate not supplied

[Progress in the treatment of advanced neuroblastoma].

Explore the source record for details and available documents.

Humans↗

PubMedDate not supplied

[Magnetic brain stimulation in treatment of depression: the search for effective parameters of stimulation].

Transcranial magnetic stimulation seems to evoke an antidepressant effect similar to that of electroshocks. This effect, however, is not accompanied by convulsions. This technique may be regarded as an alternative method of treatment of depression. It may prove as effective as electroshock treatment, but induce no negative phenomena connected with electro-convulsive treatment. Effectiveness of magnetic stimulation depends on selection of physical parameters of the applied magnetic field. In our model the optimum parameters of transcranial stimulation are: magnetic field induction B < or = 2 T stimulation frequency f [symbol: see text]¿50-100 Hz¿ time of single impulse twide [symbol: see text]¿0,1-1 ms¿ time of impulse rise trise [symbol: see text]¿(10)50-200 microseconds¿ time of impulse decline tdecline [symbol: see text]¿(100)200-1000 microseconds¿ total stimulation time ttotal > or = 1 min repetition rate repetition rate = 8-12

Animals↗