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Biomedical subjects

A Kreutner

Publications and source records attributed to A Kreutner.

At least 19 recordsLinked to original sources
PubMed1985

Histochemical examination of glycoconjugates of epithelial cells in the human fallopian tube.

In human fallopian tubes, secretory cells made up about 70% and ciliated cells most of the remainder of the epithelium. At the light microscopic level, lectin-peroxidase conjugates and other methods demonstrated on secretory cells a surface glycocalyx containing glycoconjugates with fucose residues, terminal sialic acid-beta-galactose disaccharides, and sulfate esters. Secretory cells also expressed ABO blood group antigens, on their surface, staining for terminal alpha-N-acetylgalactosamine and alpha-galactose in blood group A and B subjects, respectively. The glycocalyx coating the cilia of all ciliated cells contained an acidic glycoconjugate with terminal sialic acid-beta-galactose disaccharides. Ciliated cells ranged from strongly positive to negative in staining for blood group ABO antigens, fucose, and terminal beta-galactose. The glycocalyx on the surface of cilia differed from that on the secretory cell surface in lacking sulfate esters and possessing terminal sialic acid-beta-galactose disaccharides cytochemically unlike those on secretory cells. Cytoplasmic granules, presumably secretory in nature, stained for blood group antigen in secretory cells of some specimens. Two lectin conjugates with affinity for the core region of N-glycosidically linked oligosaccharides revealed bodies interpreted as lysosomes in ciliated and secretory cells of most specimens. The latter lectins also stained mast cells intensely, presumably because of affinity for N-acetylglucosamine. The luminal surface of endothelial cells stained heavily for fucose and for a terminal sialic acid-beta-galactose disaccharide like that on the surface of cilia. The staining for carbohydrate did not vary qualitatively, and the ratio of secretory to ciliated cells did not differ with the phase of the menstrual cycle. The salpingeal epithelium in two patients with inactive endometrium did not differ from the others. The epithelium in a specimen from a patient with uterine fibroids showed foci of mucous metaplasia, containing a nonsulfated sialylated glycoconjugate. At the electron microscopic level, fucosylated glycoconjugate was visualized with a specific lectin conjugate on the surface of the secretory cells but not on the surface of ciliated and endothelial cells. Infrequent cytoplasmic granules containing mucosubstance apparently provided the cell mechanism in secretory cells for collecting and transporting material from biosynthetic sites to the glycocalyx.(ABSTRACT TRUNCATED AT 400 WORDS)

ABO Blood-Group System↗
PubMed1979

Radical hysterectomy: a critical review of twenty-two years' experience.

One hundred seventy-eight patients who had radical hysterectomy performed for management of invasive carcinoma of the cervix over 22 year period at the Medical University of South Carolina were critically analyzed. The degree of differentiation of the malignancy appeared to be of more significance than tumor size in Stage 1 lesions. With proper patient selection and excellent operative technique, survival rates well over 90% with minimal complications can be obtained. The radical hysterectomy should never be used in association with irradiation.

Adenocarcinoma↗
PubMed1979

Case report 89.

Explore the source record for details and available documents.

Adult↗
PubMed1979

Characteristics of tissue growth into Proplast and porous polyethylene implants in bone.

(1) Bone does not form within internal pores of undistorted Proplast implants because of the small interconnecting pore size of the material; (2) the nonosseous, fibrous tissue which exists in the pores of Proplast implants in bone is not attached to the surrounding bone (i.e., Sharpey's fibers are not present). The load-bearing support which can be afforded by Proplast implants is limited by the incomplete bone ingrowth along the margins of the material and the tensile strength of Proplast.

Absorptiometry, Photon↗
PubMed1978

Intravascular papillary endothelial hyperplasia: light and electron microscopic observations of a case.

The ultrastructure of a case of intravascular papillary endothelial hyperplasia is presented. The papillae and septa within the lesion showed a similar organization. The surface was lined by a nonstratified layer of plump endothelial cells. Immediately beneath lay cells and processes of pericytes rich in thin filaments with fusiform densities, resembling smooth muscle cells. Primitive mesenchymal cells were observed to lie among the pericytes. The stroma beyond the subendothelial layer was collagenous and contained fibroblasts. The ultrastructure of the cells and their organization closely resembles human granulation tissue.

Adult↗
PubMed1977

Carcinoma of the endometrium: radiation followed immediately by operation.

A prospective study was established in August, 1967, to treat all adenocarcinomas of the endometrium by protocols of preoperative radiation followed immediately by operation. Two hundred and ninety-five women have been treated, 220 of whom had Stage I disease. In these cases, factors known to be associated with survival were studied, and their influence upon survival was noted. Preoperative radium followed immediately by operation was the primary method of therapy. Life tables demonstrated a five-year survival rate of 91 per cent with a low complication rate in patients with Stage I disease. Cell type, degree of differentiation, and depth of myomentrial invasion were the primary factors influencing survival.

Adenocarcinoma↗
PubMed1977

Cell-mediated immune responses of breast cancer patients to autologous tumor-associated antigens.

Lymphocyte proliferation assays with autologous tumor material in mixed leukocyte-tumor interactions (MLTI) were employed to monitor tumor-associated cell-mediated immune responses of peripheral blood lymphocytes from patients with carcinoma of the breast. In addition, leukocyte migration inhibition (LMI) assays were employed to compare reactivity to autologous breast-tumor extracts versus allogeneic breast-tumor extracts. Positive lymphoproliferative responses to tumor-associated antigens (TAA) were observed in the MLTI assay with the use of either intact autologous tumor cells or crude extracts (in mug and ng quantities) in 12 of 34 (35%) breast cancer patients studied. Positive reactivity to tumor, but not to normal tissue of reactive patients, was observed in repeated assays. Finally, patients demonstrating positive MLTI responses to autologous tumor extracts likewise responded in LMI assays to these same autologus extracts as well as to allogeneic breast-tumor extracts, but not to non-breast-tumor extracts. Thus breast tumors appeared to possess common TAA among both male and female patients.

Antigens, Neoplasm↗
PubMed1977

Hashimoto's thyroiditis and its relationship to other thyroid diseases.

The experience of the Medical University of South Carolina with Hashimoto's thyroiditis revealed an 8.3 per cent incidence of carcinoma. The most common type of carcinoma was an associated lymphoma. There was an additional 8.3 per cent incidence of a benign adenoma. Needle biopsy as a mechanism for diagnosing Hashimoto's disease, we believe, is inaccurate. A larger aliquot of tissue should be removed for the pathologist if there is a suspicion of an associated tumor. An open biopsy permits the pathologist to make an accurate diagnosis with a minimal amount of morbidity.

Adult↗
PubMed1976

Gonadoblastoma: clinicopathologic correlation in six patients.

Six patients with a total of nine gonadoblastomas are presented; three--and possibly a fourth--had dysgerminomatous overgrowth which was massive in two patients. Calcification detected by abdominal films was present in three sufficient for preoperative diagnosis. All patients were found to have a Y stem line on peripheral leukocyte chromosome cultures except one patient, who had a 46 XX/45 XO karyotype. She was found to have Y chromatin bodies in the germ cells of her tumor which was in a normal ovary found at exploration for an ectopic pregnancy. Three were found in virilized phenotypic females investigated for amenorrhea, and two for therapy of pelvic masses due to dysgerminomatous overgrowth. Y chromatin studies are reported on gonadal tissue.

Dysgerminoma↗
PubMed1976

Bone growth into porous high-density polyethylene.

The purpose of this study was to delineate the process by which bone comes to fill the pores of porous high-density polyethylene (PHDPE) implants. PHDPE (450 mu pore size) pellets 4 mm in diameter and 1 cm long were implanted into the femurs of dogs. A bone biopsy procedure was utilized to obtain PHDPE pellets implanted for periods of 3 days through 8 weeks. A one-year biopsy specimen taken from the PHDPE coating on the stem of a canine total-hip prosthesis was also studied. The results demonstrated that significant amounts of bone formed within the PHDPE pellets as early as 14 days after implantation. Bone was identified throughout the specimens after 4 weeks. After 6 weeks, the tissue in hematopoietic marrow. Scanning electron microscopy was utilized in conjunction with light microscopy and microradiography to study the ultrastructural features of the bone ingrowth process.

Animals↗
PubMed1976

Histology of the endometrium in long-term use of a sequential oral contraceptive.

Non-atypical adenomatous hyperplasia was found in 13.5% of 111 biopsies obtained from long-term, predominantly black, users of Oracon. An association between length of time of use (95 cycles for those with adenomatous hyperplasia versus 73 for those without) and the development of adenomatous hyperplasia was noted, but there was no association with hypertension or obesity. Cystic glandular dilatation was seen in 63% but was not thought to represent hyperplasia. No more advanced lesions were seen.

Contraceptives, Oral↗