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Biomedical subjects

A Krian

Publications and source records attributed to A Krian.

At least 55 records · Page 3Linked to original sources
PubMed1978

[The value of enzyme-determination after cardiac surgery (author's transl)].

In 342 patients undergoing open heart surgery we determined the serum enzyme levels of GOT, GPT, LDH, alpha-HBDH, LAP, CK and CK-MB from the beginning of the operation up to the 14 th postoperative day. There was an elevation of serum enzymes depending on the type of operation, the duration of extracorporal circulation and the postoperative course. A pattern of enzyme changes for uncomplicated cases is described. The investigations demonstrate a statistically significant correlation between the elevation of "liver specific enzymes" and right heart failure on one hand and of "heart specific enzymes" and myocardial ischemia on the other hand. It is concluded that only repeated determinations beginning with the operation enable to evaluate serum enzyme levels.

Adult↗
PubMed1977

[Isotopic study of cardiac hemodynamics after multiple valve prothesis (author's transl)].

The radiocardiography of the minimal transit times (MTTs) produces cardiologically useful hemodynamic data also in such instances where invasive techniques with the cardiac catheter are technically difficult, as is the case in patients with multiple valve prothesis. The present study reports on MTT measurements in 9 patients with tricuspidal prothesis, 8 of which had additional mitralvalve prothesis and 2 additional aortic valve prothesis. The measurements were made with Tc-99m Pertechnetate, and an Anger camera with electronic data processing was used as detector system. The results indicate that following implantation of valve prothesis the hemodynamic state remained essentially disturbed. The pathologically altered transit times are an expression of disturbed volume ratios. The transit times in the atria remained prolonged by an average factor of 4-5. The ejection of the left ventricle stayed diminished more pronounced than on the right. The values of one patient who was examined before and after implantation of the prothesis in mitral and tricuspidal position, also showed a worsening of the data especially in the atria. Because the cardiac function study with radioisotopes is non invasive, simple, and fast, and leads to only a minor radiation burden, the method may be repeated and without hazard used for control follow-ups.

Adult↗
PubMed1976

[New aspects in the treatment of pneumonitis (author's transl)].

Two groups of patients suffering from pneumonitis received different treatments and were compared retrospectively. The first group (38 patients) was treated with heparin and aprotinin. The overall mortality was 50 percent; of the patients who were artifically ventilated 64 percent died. The second group (60 patients) was treated with heparin, fresh-frozen plasma, nicotinic acid, methylprednisolone, and alpha-receptor blocking agents. In this group the overall mortality was 26.5 percent and the mortality among the patients who were artificially ventilated was 33 percent. These results lead the authors to feel that the treatment of pneumonitis with aprotinin is no longer indicated.

Adolescent↗
PubMed1976

[Postoperative acute renal failure (author's transl)].

Despite progress in intensive therapy and dialysis the lethality of postoperative acute renal failure (ARF) remains very high. Between 1958 and 1976, 374 out of 11474 patients treated in the intensive care unit developed ARF. By conservative treatment that is described in detail, the mortality was reduced from 80 percent (up to 1972) to 50 percent. The mortality rate of dialysis was 86 percent (85 of 98 patients). ARF reflects the severity of the illness of these patients. The prognosis depends besides further complications on the administration of optimal intensive care and early dialysis.

Acute Kidney Injury↗
PubMed1976

[Surgical management of acquired tricuspid insufficiency--valvular replacement or annuloplasty? (author's transl)].

61 patient underwent operative repair of acquired tricuspid insufficiency (T.I.) during correction of multiple valvular disease. 45% presented a relative T.I. through annular dilatation, while organic lesions of the tricuspid valve were found in 56% of the patients. A tricuspid valvular replacement was carried out in 17, and a tricuspid annuloplasty in 44 patients. We believe that during surgical management of multiple valvular lesions, all tricuspid insufficiencies of even when only of a slight to moderate degree - should be corrected aggressively. Tricuspid valvular replacement should be avoided if possible and a tricuspid annuloplasty should be performed.

Adolescent↗
PubMed1976

[Obstruction of the hepatic portion of the inferior vena cava: morphological characteristics and surgical treatment (author's transl)].

Operable obstructions of the hepatic portion of the inferior vena cava (IVC) are rare but probably diagnosed more frequently nowadays. Since 1969 we operated 2 patients, one of them twice. Concerning to these cases the problems of diagnosis, morphology and surgical treatment are discussed. In the patient, who were operated twice, we found the combination - which has not been reported in medical literature yet - of a membranous stenosis of the hepatic portion of the IVC and a large Eustachian valve obstructing the IVC.

Budd-Chiari Syndrome↗
PubMed1975

[Experiences in the treatment of acute renal failure following cardiovascular surgery (author's transl)].

After 9021 cardiovascular operations 210 patients developed acute renal failure. 140 (67%) out of this group died. The mortality rate of acute renal failure could be reduced from 80% (1958-1966) to 50% (1973-1974). Dialysis treatment should begin early and also in special cases, in which the cause of acute renal failure is not under control. Beyond optimal dialysis therapy common intensive care is important for the prognosis of acute renal failure, especially adaption of drugs to renal function (antibiotics and digitalis), high-caloric alimentation, consequent treatment of infections, strict balance of fluid and electrolytes.

Acute Kidney Injury↗
PubMed1975

[Findings of scanning microscopy studies and gas-transfer results in long-term perfusions using membrane oxygenators in animal experiment].

Twelve hours partial extracorporeal circulation using the GEDL was carried out in sheep with experimental pulmonary insufficiency. The maximal O2-transfer was 53,8 ccm/min/m2 membrane surface at blood flows of 2 and 3 1/min. The CO2-transfer was nearly 30 ccm/min/m2 if the pCO2 was within the normal range. There was evidence, that the O2-transfer decreases during prolonged perfusion. Scanning-electron-microscopic studies revealed a thickening of the membrane with protein and cell-fragments which were thought to be the reason for the observed decrease in O2-transfer.

Animals↗