[Results of fractionation optimization of tumours of the bladder in homogeneous patient collectives (author's transl)].
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Biomedical subjects
Publications and source records attributed to A Kriester.
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During four years a prospective study was carried out on 59 women, who had ovariectomized bilaterally for non-malignant diseases. It was studied the loss of the body length, the loss of bone mineral content in a middle phalanx expressed as percentage and several x-ray criteria. By means of combined performance signs of a beginning osteoporosis were found in 59 per cent of women after 2 years and in 68 per cent after 4 years after ovariectomy. -- The authors recommend relative simple screening methods: observation of body length, the dual beam x-ray spectrophotometry (Krokowski) and the minimal combined cortex thickness of the proximal radius according Meema. Women undergoing ovariectomy before the menopause should be attended by medical teamwork. The results of oestrogen prophylaxis were not so convincing as other investigators described.
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The present paper reports on problems and results of treatment of urinary bladder carcinoma in 160 patients over 70 years of age. The 2-year survival rate was 44%, the 5-year survival rate was 19%. According to our results transurethral electroresection followed by high voltage radiation proved to be superior to other procedures in patients over 70 years of age.
The effect of several fractionation regimes was examined by the model of mammary tumour in C3H-mice. The best results were observed with several fractionations daily. No curative effect was obtained by means of a total dose of 6000 rd achieved with all fractionation regimes. The results of investigations underline the importance of considering cellular proliferation kinetic processes in malignant tumours in order to optimize the temporal distribution of radiation dose.
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The left kidneys of rabbits were fractionally irradiated to a total dose of 6.000 R. Renal function was regularly monitored by isotope nephrography. Semiquantitative measurements (Zum Winkel) and comparison to the two sides (Bargon and Emrich) show changes in renal function in the functional and excretory phases; these, however, were less marked than after single dose irradiation. The results are discussed with reference to the relevant literature.
Systematic investigations of the chorionic gonadotropin excretion were performed in 79 patients with testicular tumours. The influence of the hormonal activity in diagnosis and prognosis of metastatic testicular tumours was investigated. It was discovered, that the part of hormonal active testicular tumours is relatively small and that the evidence of the chorionic gonadotropin excretion is only possible in a few cases before the clinical and radiological evidence of metastases. The hormonal activity of testicular tumours is without influence on the survival time of tumour carriers.
In 96 out of 250 cases of bladder cancer, neoplastic tissue was found by biopsy in areas within the bladder but remote of the primary and unsuspiciously looking mucosa. Neither the histologic type of the tumour nor the degree of infiltration of the primary allow predictions regarding remote cancerous lesions within the bladder. It must be concluded: In bladder cancer, indication and choice of treatment must take into consideration that the neoplastic process involves the urinary bladder as a whole.
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