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Biomedical subjects

A Kroese

Publications and source records attributed to A Kroese.

14 recordsLinked to original sources

[Ultrasonography for early diagnosis of abdominal aortic aneurysm].

2,654 males aged 60 years or older were invited to attend a screening examination using ultrasound to detect abdominal aortic aneurysm. 1,256 met up. A fee of NOK 150 was charged. 92 aneurysms were detected (7.3%) 69 were smaller than 40 mm and 23 were 40 mm or larger. During the observation period (18 months from start of the study and nine months after screening stopped) 17 of the patients with an abdominal aortic aneurysm of 40 mm or larger had elective operations. All patients survived without major complications. Owing to the high prevalence of abdominal aortic aneurysm, the low cost of screening, and the safety of elective surgery, it is suggested that screening for detection of abdominal aortic aneurysm should be carried out on a larger scale.

Aged

Ultrasonographic screening for abdominal aortic aneurysm.

OBJECTIVE: To assess the prevalence of abdominal aortic aneurysm in a selected group of men over the age of 60, and define main risk factors. DESIGN: Population based screening study. SETTING: Private Norwegian health maintenance organisation. SUBJECTS: 500 men over the age of 60 years. INTERVENTIONS: General examination by a general practitioner, together with measurements of blood glucose and serum cholesterol concentrations. Abdominal scan with a B-mode ultrasound imager. MAIN OUTCOME MEASURES: An increase in the diameter of the aorta of more than 150% over the diameter at the origin of the superior mesenteric artery, or maximum diameter of more than 29 mm. Correlation with history of smoking, serum cholesterol concentration, and general health. RESULTS: 29 patients (5.8%) had small, and 12 (2.4%) had large, abdominal aortic aneurysms. There was a significant association between aortic aneurysm and history of smoking (p < 0.01), poor health (defined as coexistent hypertension, cardiovascular disease, or diabetes mellitus) (p < 0.01), and increasing age (p = 0.025). There was no association with hypercholesterolaemia. CONCLUSION: Ultrasonic screening of groups at risk followed by elective operation may reduce mortality of abdominal aortic aneurysm.

Age Factors

Laser Doppler flowmetry in evaluation of lower limb resting skin circulation. A study in healthy controls and atherosclerotic patients.

Laser Doppler flowmetry (LDF) was used to evaluate lower limb resting skin perfusion in sixty subjects divided into four groups: healthy young and elderly controls, and patients with intermittent claudication or critical ischaemia. Measurements were performed in pulp skin containing microvascular AV anastomoses and in the skin of leg and thigh where these shunts are absent. In toe pulp controls and claudicators had higher perfusion values than in leg and thigh skin (p less than 0.01), indicating that the LDF method evaluates flow both in nutritional capillaries, AV anastomoses and in dermal vascular plexa. Elderly controls had higher flux values in the pulp than claudicators (p less than 0.01), and claudicators had higher values than patients with critical ischaemia (p less than 0.01), showing that LDF could differentiate between the clinical groups. Study of reproducibility confirmed that values were reproducible on a given population. Day to day variation was considerable in individual subjects, probably because of changes in sympathetic vascular tone and because of different vascular architecture in the measuring volumes which are only some few mm3. The fact that LDF measures total skin blood flow explains why several papers have found a poor correlation between LDF and methods which mainly evaluate nutritional blood flow. The method is non-invasive, continuous and easy to perform. Laser Doppler flowmetry may have several clinical applications, like evaluating progress of atherosclerotic disease or therapeutic effects of drugs or operations. To increase the reproducibility of resting skin flux measurements local heating of the skin is recommended and the measurements should be performed with an integrating probe, which averages the readings obtained at several positions simultaneously.

Adult

Ketanserin in intermittent claudication: effect on walking distance, blood pressure, and cardiovascular complications.

In a 7-center Scandinavian double-blind placebo-controlled study of 179 patients with intermittent claudication, the effect of the serotonin antagonist ketanserin was evaluated on walking distance, brachial and ankle blood pressure, and symptoms. For all centers together, pain-free walking distance was significantly increased after 6 months with both ketanserin (+65%; 71 patients) and placebo (+42%; 78 patients), with no significant difference. However, there was large variability among centers. Classification of "responders" (doubling of walking distance) and patients who deteriorated (decrease of walking distance or dropout for inefficacy) showed significantly more patients responding and significantly fewer patients deteriorating with ketanserin than with placebo. Systemic blood pressure was significantly decreased by ketanserin in hypertensive, but not normotensive, patients, while ankle pressure was unaffected. The incidence and nature of side effects were equal with ketanserin and placebo, but there were more side effects causing dropout in the ketanserin group. An unexpected and possibly important observation was the occurrence of six serious cardiovascular events (myocardial infarction, cerebrovascular complications, and development of rest pain) in the placebo group but none in ketanserin-treated patients. Moreover, there were four additional similar complications in the placebo run-in period. Ketanserin appears to be beneficial in a subgroup of patients with intermittent claudication. A fortuitous finding of this study is that ketanserin might possess a protective effect against thrombovascular complications in patients with intermittent claudication.

Adult

Early complications with a new bovine arterial graft (Solcograft-P).

In three separate centers of vascular surgery in Norway, a total of 26 patients underwent implantation of a new bovine arterial graft (Solcograft-P) for femoropopliteal or femorotibial bypass or arterial patch-plasty. Serious complications--graft deterioration and formation of aneurysm or pseudoaneurysm--arose in eight patients, all within 4 months after the implantation. In central Europe only four anastomotic pseudoaneurysms have been reported after about 700 Solcograft implantations, even with longer observation time. Possible causes of the difference in complication rates are discussed.

Aged

Axillo-axillary bypass for subclavian artery occlusion. Report of a case with impending gangrene of the hand.

A 72-year-old woman with occlusion of the right subclavian artery and impending gangrene of the hand was succssfully treated with a subcutaneous axillo-axillary vein bypass. This method was chosen because of atrophic skin changes due to radiation therapy for breast cancer. The operation may, however, be used in the treatment of atherosclerotic obstructions of the subclavian artery in general and may be particularly advantageous in old and poor risk patients.

Arterial Occlusive Diseases

Blood circulating changes in the eye and limbs with relation to pregnancy and female sex hormones.

Alterations in corneal indentation pulse (CIP) amplitudes and pulse volume recordings (PVR) on the limbs were demonstrated in pregnant women, indicating that significant changes occur in the peripheral blood circulation during pregnancy. The PVR measured at week 30-36 of gestation demonstrated a significant increase when recorded on the forearm and index finger. In the eye an increase in CIP amplitudes was found early in pregnancy. From week 20 on, however, a steady decrease occurred, until the CIP amplitudes at term averaged about 1/3 of the values from normal, non-pregnant women. Similar changes, although less pronounced, were demonstrated in the ocular blood circulation during oral contraceptive treatment and, to some extent, during menstruation. Intake of gestagens and diaethyl-stilboestrol did not alter the CIP amplitudes.

Adolescent

The Christiansen hip prosthesis preliminary results.

The combined endo- and total hip prosthesis of Christiansen is described. In this prosthesis an articular connection, or trunnion bearing, is introduced between the head and stem components in order to reduce friction at the acetabular joint. The stem portions of both prostheses are identical. The endoprosthesis was inserted in 50 patients, who were followed-up during one year. The results were according to the classification of Love (Surg. Clin. N. Amer., 1963, 43, p. 1217): excellent in 60%, good in 22%, and poor in 18% of cases. In addition some results from other Norwegian hospitals were presented.

Femoral Neck Fractures

Hyperaemia of the calf after arterial reconstruction for lower limb atherosclerosis. A study with mercury strain gauge plethysmography.

Postoperative hyperaemia in the calf was studied in 25 patients successfully operated for obstructing atherosclerosis of the lower limbs. The calf flow was measured by strain gauge plethysmography. No difference in the preoperative calf flow between the patients and the control group was found. The flow at rest in the operated limb increased to a maximum on the 5th postoperative day, at which time it was 2.4 times the flow in the control leg. A significant correlation was found between the postoperative hyperaemia and the preoperative ankle pressure. These findings support the theory of Husni & Manion (1966), that there is a greater postoperative hyperaemia in patients with severe atherosclerosis. No significant correlation was found between the postoperative hyperaemia on the one hand and (1) the preoperative arterial flow increase after reconstruction, (2) the maximum flow increase in the artery after intra-arterial injection of papaverin or (3) clinical symptoms and angiographic findings on the other.

Aged