Biomedical subjects

A Kufner

Publications and source records attributed to A Kufner.

3 recordsLinked to original sources

PubMed1987

[Cultivated epidermis as a skin replacement--improved technics using mesh silastic sheets].

The cover of cutaneous wounds with cultured epidermis can be significantly improved by prior backing of the epithelium with meshed silastic sheets, whereas other materials, such as vaseline gauze, foam rubber etc., are not as satisfactory. Meshed silastic is affixed to the epithelium surface just before the enzymatic detachment from the culture flask is completed. Thus it protects the delicate epithelial membrane from injury during transplantation and helps to control its polar orientation. In addition, the silastic mesh prevents the graft, which initially does not possess any horny layer, from drying up and allows adequate drainage of wound secretions. Cultured epidermal grafts prepared by this method take very well (more than 90%) attaching to the wound bed quite firmly within a week.

Bandages↗

PubMed1985

[Allergic granulomatosis (Churg-Strauss syndrome)].

Allergic granulomatosis is a rare life-threatening systemic disorder of unknown origin, which represents a variant of systemic necrotizing vasculitis affecting medium-sized arteries and venules. Histologically, allergic granulomatosis is characterized by vascular and extravascular necrotizing palisading granulomas with prominent eosinophilia (Churg-Strauss granulomas). The clinical criteria include atopy with severe allergic asthma, pronounced peripheral eosinophilia, and nodular infiltrates of the skin and internal organs (Churg-Strauss granulomas). The internal organs most commonly involved are the lungs, gastrointestinal tract and, less often, the peripheral nerves, heart, and kidneys. Associated symptoms include fever, arthralgias and skin rashes, such as erythema multiforme, necrotizing venolitis, fixed drug eruption, and urticaria. Allergic granulomatosis shares common features with Wegener's granulomatosis and polyarteritis nodosa and may be related to the latter condition; overlap syndromes are a well-known occurrence. Similar to the other manifestations of systemic necrotizing vasculitis, immune complexes have been detected in fresh lesions and are suspected of being the basic pathogenetic findings. The causative antigens are likely to be respiratory antigens. The prognosis of untreated allergic granulomatosis is poor (mortality of approximately 50% within the first year). Systemic corticosteroids and cyclophosphamide are effective; complete remissions following cyclophosphamide treatment have been reported.

Adult↗

PubMed1980

[Acute implantation technique of the ellipsoid heart for clinical left ventricular assistance (author's transl)].

The results of the first clinical trials of left ventricular assist devices are not encouraging. The only indication at present is in patients with cardiac failure after cardiac operations. The acute type of ellipsoid heart described in this paper-displays a canulation technique where the inflow canula inserted in the left ventricular cavity via the left atrium and the outflow canula is directly connected to the aortic canula of the cardiopulmonary bypass. The haemodynamic response shows the efficacy of this system. The circulation can be maintained in severe cardiac failure, as well as in ventricular fibrillation and cardiac arrest. On the basis of data obtained in experiments on 7 female calves this system is considered worthy of clinical trial.

Aorta↗