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Biomedical subjects

A Kuhlwein

Publications and source records attributed to A Kuhlwein.

At least 19 recordsLinked to original sources
PubMed1990

[Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes].

Pain syndromes of the lumbar spine are one of the main problems in orthopedic practice. The therapeutic effect of NSAIDs is not subject to doubt in this connection. But considering that the application of NSAIDs is frequently associated with side effects, a reduction of dosage would be to the patient's benefit. Clinical studies have shown that concomitant treatment with vitamins B1, B6, B12 and diclofenac leads to a more efficient pain relief than treatment using diclofenac alone and thus provides the possibility of saving NSAIDs. This clinical trial was carried out in order to determine whether these results can also be achieved when a reduced dosage of diclofenac (75 mg daily) is used. 123 patients with acute pain syndromes of the lumbar spine were treated with either B-vitamins and diclofenac or diclofenac alone for a maximum of 7 days. There was the option to terminate therapy in the trial after 3-4 days in the case of total pain relief. 45 patients could stop the treatment due to remission of symptoms. 30 patients belonged to the combination therapy group, the other 15 took diclofenac alone; this difference is statistically significant (p less than 0.05). All parameters concerning pain relief and movement of the vertebral column showed statistically significant differences in favour of the B-vitamin-diclofenac-combination, too. The results document the positive influence of B-vitamins on painful vertebral syndromes and indicate that B-vitamins contribute to saving of NSAIDs by shortening the treatment time and reducing daily NSAID-dosage.

Adolescent↗
PubMed1989

[Fungal involvement of the penis in patients with penile condylomata acuminata].

In a study on 129 patients with penile condylomata acuminata we recognised an incidence of 32% penile yeast affection. Candida was found in 54%, Torulopsis in 30% and Rhodotorula in 17% of all cases. The high rate of yeasts not belonging to the candida species is remarkable. There was no correlation between our test results regarding the cell-mediated immunity against candida albicans and the local yeast infection.

Adolescent↗
PubMed1988

[Condylomata acuminata and HIV infection--an epidemiologic study].

Within a period of 15 months, 134 patients suffering from condylomata acuminata were investigated with regard to simultaneous infection with HIV. 3 of these patients--2 showing warts in the anal region, 1 on the glans penis--were found positive for anti-HIV antibodies.

Acquired Immunodeficiency Syndrome↗
PubMed1988

[Fungal involvement of the intestinal tract in HIV-positive males].

In a retrospective study on 21 HIV-positive patients (aged between 18 and 28) in stage WR 1 CDC II and WR 2 CDC III, we looked for yeast in tongue swabs and stool samples. About 2/3 of the cultures of stage WR 1 CDC II and nearly all cultures of stage WR CDC III revealed infection with yeasts.

Acquired Immunodeficiency Syndrome↗
PubMed1988

[Linear circumscribed scleroderma--case report. Classification and differentiation of circumscribed scleroderma].

In linear scleroderma, a rare form of circumscribed scleroderma, the lesions are arranged in a band-shaped linear distribution and both the superficial and the deeper layers of the skin are attached to the underlying structures. This disease must principally be differentiated from eosinophilic fasciitis (Shulman's syndrome). On the basis of the clinical and laboratory data, systemic scleroderma can be excluded in nearly all the cases. Nevertheless, patients with linear scleroderma might develop systemic scleroderma or other systemic diseases of the connective tissue even after years. As a consequence, thorough physical examination as well as laboratory evaluation is necessary over a long follow-up period. We introduce a new classification of circumscribed scleroderma.

Adult↗
PubMed1988

[Cutaneous myxoma (focal dermal mucinosis)].

Two cases of cutaneous myxoma are presented. In case 1 the cutaneous myxoma was localized on the left thumb and clinically resembled a pyogenic granuloma. In case 2 it was found at the left nipple. The benign cutaneous tumor may herald a cardiac myxoma and other conditions. Thus, a cutaneous myxoma should be accepted as an indication for thorough investigation of the whole body at regular intervals. As there are neither clinically nor histologically adequate criteria for differentiation, cutaneous myxoma and focal dermal mucinosis can be considered as variants of a single entity.

Diagnosis, Differential↗
PubMed1987

[Urticaria pigmentosa adultorum and systemic mastocytosis--diagnostic principles and therapeutic possibilities].

We report on the clinical picture of urticaria pigmentosa adultorum and systemic mastocytosis. In four out of five patients, we proved systemic mastocytosis by means of a biopsy from the iliac crest, although these patients did not complain of systemic signs and symptoms. In all cases, the cutaneous changes and clinical symptoms could be improved by a four-week-heliotherapy in the North Sea summer climate; itching did not reappear but five months later. Heliotherapy is regarded as an useful alternative concerning the treatment of urticaria pigmentosa and cutaneous manifestation of systemic mastocytosis.

Adult↗
PubMed1987

[Subungual exostosis].

Representative of seven cases observed during the last four years, we report on two cases of subungual exostosis. We present the clinical symptoms, our radiographical and histopathological findings, as well as the possible differential diagnoses. Local curettage or excision are regarded as the treatment of choice.

Adult↗
PubMed1987

[Cell-mediated immune reaction in patients with condylomata acuminata C. A.)].

A study on cellularly mediated immune reaction in male patients aged between 18 and 30 years and suffering from condylomata acuminata (C.A.) revealed immune suppression particularly of the cellularly mediated system. As compared with the normal population, our study proved a significantly increased portion of hypergic patients and a clear decrease of the various groups of lymphocytes.

Adolescent↗
PubMed1986

[Jadassohn type anetoderma--case report].

A 19-year-old patient suffering from Jadassohn's anetoderma with progressive dermatrophia showed positive reaction to treatment with chloroquin diphosphate.

Actin Cytoskeleton↗
PubMed1986

[Osseous choristoma in vitiligo].

This article deals with a typical case of both the conditions vitiligo and osseous choristoma of the intraoral soft tissue. Because of the close association between vitiligo and other diseases, it is very important to have each patient thoroughly examined with regard to thyroid diseases, pernicious anemia, diabetes mellitus, and autoimmune phenomena. We have detected a very rare tumescence of mature bony tissue, such as described in literature in only 25 cases, so far.

Adult↗
PubMed1985

[Female pattern androgenic alopecia in the male].

The schematic description of male pattern baldness neglects the fact that special forms of baldness in males have a rather female pattern aspect. Here we report on a man with female pattern alopecia.

Adult↗
PubMed1985

[Light microscopic studies of spermatogenesis in rats following the administration of a high dose of 13-cis-retinoic acid].

In an experimental study, we investigated the influence of a toxic dose of 13-cis-retinoic acid (40 mg per kg body weight daily) on the spermatogenesis of 30 Wistar rats. 15 rats were killed immediately after 8 weeks application; the remaining 15 animals were put to death after another 8 weeks without application. A control group of another 20 rats only received physiological salt solution daily over a period of 8 weeks. All 30 rats which had been treated with 13-cis-retinoic acid showed as normal a spermatogenesis in all parts of the testes as the 20 control animals.

Animals↗