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Biomedical subjects

A Kunicki

Publications and source records attributed to A Kunicki.

At least 19 recordsLinked to original sources
PubMed1983

Some remarks on the mode of spread of primary benign brain-stem tumours based on description of three cases.

On the basis of long-standing own experiences and the literature, the author subdivides the tumours mentioned in the title into two types. Type A (occurring most frequently): Developing in the transversal plane and the longitudinal axis; typical clinical signs on cerebral nerves, long pathways and cerebellar pathways. Choked papilla and signs of cerebral compression develop late or not at all. Surgical removal is impossible. Type B: Tumour growth in the 4th ventricle and subarachnoid space without infiltration of deeper brain-stem structures. Signs of cerebral compression in the early phase. Signs of transversal damage of the brain stem are slight and disappear after decompression. Partial removal and subsequent irradiation lead to a far-reaching freedom from symptoms and a socially useful survival over many years. So these tumours should be operated on with subsequent irradiation.

Adolescent↗
PubMed1982

CSF absorptive capacity in patients without intracranial pathology.

The role of changes in CSF inflow in patients without intracranial pathology has been studied. The CSF outflow resistance has been calculated, by dividing the CSF pressure rise by the speed of intrathecal saline infusion. The average CSF pressure rise produced during infusion test (infusion 2 ml/min) amounted to 11.15 mmHg. The calculated CSF outflow resistance equaled to 5.58 +/- 1.1 mm Hg/ml/min. On-line computer assisted analysis during infusion test helps to shorten the procedure and makes it more precise.

Adult↗
PubMed1980

[Immediate and remote results of treatment of cerebellar astrocytoma].

Cerebellar astrocytoma accounted for 10% of all brain tumours treated at the Department of Neurosurgery, Medical Academy in Cracow in the years 1946 to 1968. It accounted for 16.6% of all gliomas, and 57% of subtentorial gliomas. Table I shows the distribution of the tumour according to age groups. The male:female sex ratio was near 1.0. In 124 cases the tumour was situated in the cerebellar hemispheres and in 91 in the vermis. The present study is based on an analysis of 215 cases with 124 tumours in the hemispheres and 91 in the vermis. In the hemispheres 77.8% of astrocytomas had cavities, while 22.2% were solid. In the vermis 60.6% of the tumours had cavities and 39.4% had no cavities. Infiltration of the brain stem or adherence to the floor of the fourth ventricle are mentioned in the protocols of 19 operations. The most frequent tumour in childhood and adolescence was pilocytic astrocytoma, in adulthood fibrillary and protoplasmic astrocytomas prevailed. In 10 cases of the last mentioned variety evidence of anaplasia was found. In the first four years when all operations were performed under local analgesia or rectal general anaesthesia the operative mortality was 21.5%, and in the subgroup of 40 first cases it was even 25%. After introduction of endotracheal anaesthesia the operative mortality fell to 13%, and in the subgroup of 40 last cases it was 9%. Detailed data about follow-up observations are available in 93 cases. Thirteen of them were disabled because of complete or nearly complete loss of vision. Nine of them completed schools for the blind and work in gainful occupations ad two founded families. Three patients are completely disabled because of equilibrium disturbances and ataxia. Two children attended a special school. The remaining 85 patients regarded themselves as healthy. This group comprised 66 patients operated upon at the age from 2 to 14 years, 12 were treated at the age from 15 to 21 years and 7 above that age. Some of them had high school education, others were doing heavy manual work, and many others attended secondary or high schools. Among the female patients 13 were mothers who gave birth to 23 children. (Table I). The fates of our patients confirm the view that in most cases cerebellar astrocytoma is surgically curable. The limit of radical operation is finding of brain stem infiltration observed in about 11% of cases. Partial removal of the tumour does not protect against recurrence but in some cases symptom-free periods of many years' duration were reported.

Adolescent↗
PubMed1977

A fast method of estimating the elastance of the intracranial system.

The authors describe a fast method for estimating the elastance of the intracranial system in man. The method consists in constructing the so-called amplitude-pressure (Amp-P) curve which describes the relationship between the amplitude of pulse-related oscillations in cerebrospinal fluid pressure and the basic level of intracranial pressure. The Amp-P curve consists of two straight lines, and the point of intersection of these lines is thought to indicate the intracranial pressure level at which there occurs a qualitative change in the functioning of compensatory mechanisms of the intracranial system. The authors applied the method to examine the Amp-P curves of 10 patients without intracranial pathology and found that they provide a good description of the state and dynamics of the intracranial system. Preliminary data obtained in patients with intracranial pathology indicate that the method is a valuable tool in the diagnosis and treatment of neurosurgical patients.

Adult↗
PubMed1977

[Effect of sudden decompression on tissue pressure in the brain and the cerebrospinal fluid pressure].

Extracranial hypertension was produced in cats by means of epidural compression with a baloon. After 2 hours of compression sudden decompression was performed and tissue pressure was compared at symmetrical sites of cerebral hemispheres with cerebrospinal fluid pressure measured in the cisterna magna. It was found that symmetrical tissue pystem, which was due probably to early oedema developing in the compressed area.

Animals↗
PubMed1976

A method of estimating intracranial decompensation in man.

A new method of estimating intracranial decompensation in man is described. An on-line computer system is connected to an intracranial pressure (ICP) monitoring system to compute regression plots of mean ICP vs standard deviation; standard deviation is used as a measure of ICP instability. Two zones with distinctly different slopes are a characteristic feature of these plots. It is thought that the changes of slope signify intracranial decompensation.

Humans↗
PubMed1975

A computerized neurosurgical intensive care system.

A specialized neurosurgical data acquisition and processing system was developed and applied in practice to monitor some 60 patients after head injury or neurosurgical operations. At first the system allowed off-line operation, and the experiences thus gained made it possible to implement the system in its present form for real-time on-line patient monitoring. The algorithms prepared in our laboratory allow rapid and concise presentation of results and have proved their usefulness in clinical practice. The main parameters of interest in neurosurgery are intracranial pressure (ICP) and the volume of cerebrospinal fluid (CSF) drained from one of the lateral ventricles. Examples of statistical analysis of both these variables, and their presentation in the form of tables, diagrams and histograms are given.

Adolescent↗
PubMed1975

Computer-assisted analysis of intraventricular pressure after mannitol administration.

The effect of prolonged mannitol infusion upon intraventricular pressure was investigated with the aid of a specially-designed automatic digital recording system; the data recorded were processed off-line by a minicomputer. The character of the pressure curves is thought to result from interaction between the mannitol effect and the observed system's shifting equilibrium position, which is caused by other factors. The character of the pressure curves prior to mannitol infusion must be taken into consideration in estimating the actual effect of the drug; the authors suggest that in certain cases it might be possible to decrease further the rate of mannitol administration. The advantages of statistical approach to the evaluation of intracranial pressure variations are discussed.

Analysis of Variance↗