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Biomedical subjects

A Kunii

Publications and source records attributed to A Kunii.

At least 19 recordsLinked to original sources
PubMed1989

T-cell malignancy following B-cell lymphoma in remission.

A T-cell malignancy developed in a 64-year-old man with recurrent B-cell lymphoma after one and a half years of remission. Immunophenotypic and DNA analyses confirmed clonality and cell lineage of both lymphoid malignancies. Sequential development of B- and T-cell malignancies in this patient may be an example of biclonal lymphoma or treatment-related secondary lymphoma. However, another possibility would be the existence of a transformed lymphoid stem cell that underwent intraclonal conversion from B- to T-cell lines.

Antibodies, Viral↗
PubMed1989

Weekly CHOP for the treatment of advanced intermediate and high-grade non-Hodgkin's lymphoma.

Between January 1981 and September 1986, 48 patients with advanced (stages III and IV) intermediate and high-grade non-Hodgkin's lymphoma (NHL) were treated with weekly CHOP (doxorubicin, vincristine, cyclophosphamide, and prednisolone), using reduced dosages of cyclophosphamide and doxorubicin. Low-dose oral maintenance chemotherapy was given for 2 years to those patients in remission. Twenty-seven patients (56%) of the evaluable 48 patients achieved a complete response and 12 patients (25%) had a partial response, for an overall response rate of 81%. The relapse-free survival for complete responders has been at a plateau of 67% at 16 months, and actuarial survival for complete responders has been 62%, with no deaths occurring beyond 43 months (survival plateau). One treatment-related death occurred, but toxicity was generally modest. The median time required from the start of weekly CHOP to complete response was only 5 weeks. Weekly CHOP can achieve results similar to those obtained by currently popular regimens utilizing a greater number of drugs at higher dosages.

Actuarial Analysis↗
PubMed1989

T-cell phenotype is associated with decreased survival in non-Hodgkin's lymphoma.

This study was undertaken to determine which if any pretreatment factors are statistically significant determinants of the clinical outcome in patients with non-Hodgkin's lymphoma. The pretreatment factors in 20 patients with T-cell lymphoma, including two patients with adult T-cell leukemia/lymphoma (ATLL), and 28 patients with B-cell lymphoma were evaluated. In a stepwise logistic regression analysis, a T-cell phenotype in addition to high grade histology and pleural involvement demonstrated a statistically significant correlation with decreased response rate, when the analysis did not include patients with ATLL. Analysis by means of the Cox proportional hazards model disclosed that the T-cell phenotype retained a statistically significant correlation with survival after adjustments for other prognostic factors, whether the study included the patients with ATLL or not. The decreased response rate and survival of Japanese patients with non-Hodgkin's lymphoma in comparison with those reported in Western countries seem to be due to increased intrusion of T-cell lymphomas. To permit a reliable comparison of reports on new chemotherapeutic regimens from different institutions, the tumor phenotype must be determined in the population studied.

Aged↗
PubMed1989

Relationship between immunophenotype and the development of second primary neoplasms in patients with non-Hodgkin's lymphoma.

We reviewed the records of 107 patients with non-Hodgkin's lymphoma (NHL) to evaluate the relation between second primary neoplasms and the NHL immunophenotype. The incidence of second primary neoplasms was 3.7%. There were one case of hepatocellular carcinoma and 3 cases of gastric adenocarcinoma including one patient who had a history of metachronous malignant lymphomas. Three patients had B cell lymphoma with monoclonal IgM kappa phenotype, and one patient had follicular mixed cell type lymphoma with serum monoclonal IgM kappa. The dominant immunophenotype of B cell lymphomas in Japanese patients is IgM lambda. We believe that the association of the uncommon phenotype of IgM kappa with second primary neoplasms, especially gastric cancer, reflects an underlying genetic predisposition. NHL patients with IgM kappa phenotype should be evaluated carefully for second primary neoplasms.

Adenocarcinoma↗
PubMed1989

[Clinical studies on eleven patients with nasal and paranasal lymphoma, with special reference to staging evaluation].

Adequacy of applying Ann Arbor classification and TNM classification to evaluate extent of disease in extranodal lymphoma was assessed in patients with nasal and paranasal lymphoma. Ann Arbor classification proposed to evaluate extent of Hodgkin's disease was not considered to be good at assessing extranodal local lesions. TNM classification was superior to Ann Arbor classification in terms of the correspondence with survival. Patients with nasal and paranasal lymphoma of T3 and T4 stage (TNM classification) were prone to develop bone marrow and CNS spread.

Adult↗
PubMed1989

[Evaluation of the response of advanced diffuse large cell lymphomas (LSG classification) to weekly CHOP therapy].

"Weekly CHOP" therapy characterized by reduced dosages of cyclophosphamide, doxorubicin and vincristine, was evaluated in 33 patients with advanced diffuse large cell lymphomas (LSG classification). There were 19 complete responders (59%) and 8 partial responders (25%) with a response rate of 84%. A prolonged disease-free survival rate (survival plateau) of 60% was considered comparable to the results of second-generation chemotherapies. The response was poor in patients with high grade malignancy (large cell, immunoblastic category in Working Formulation for Clinical Usage) as well as in patients with bone marrow invasion.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

[Clinical analyses on 10 patients with follicular lymphoma].

Clinicopathologic analyses were done on 10 patients with follicular lymphoma including 8 patients with low grade malignancy. The complete response rate to chemo- and combined modality therapy was 80% with no deaths occurring in patients in complete remission with median follow-up of 73 months. The 5-years' survival for these 10 patients was 86%. There were two patients with second primary neoplasm, one with gastric cancer detected one year after initiation of chemotherapy, the other with leiomyosarcoma detected 3 years after cessation of chemotherapy. Histologic transformation from follicular medium sized cell to diffuse large cell was noted in one patient.

Adult↗
PubMed1989

[Clinicopathologic analyses of eleven patients with Hodgkin's disease].

Clinicopathologic analyses were performed on 11 patients with histopathologic diagnosis of Hodgkin's disease which was confirmed immunohistochemically with the use of anti-Leu M 1 which is known to be specific to Reed-Sternberg cells. Patients with clinical stage II developed infradiaphragmatic involvement after Mantle field irradiation and should have been treated with extended field irradiation or combined modality therapy because of the possibility of PSIII1. Maintenance VENP therapy seemed to sustain remission but may have caused opportunistic infections. There were no rearrangements in either immunoglobulin or T cell receptor genes studied in two patients.

Adolescent↗
PubMed1987

Bone marrow Ig-secreting cells in patients with malignant lymphoma.

Bone marrow immunoglobulin (Ig)-secreting cells of three major Ig classes were quantitated in patients with malignant lymphoma with or without definite bone marrow invasion, using a protein A hemolytic plaque assay. The mean percentage of each class of Ig-secreting cells in patients without bone marrow invasion was 77% for IgG, 17% for IgA, and 6% for IgM, whereas it was 86% for IgG, 6% for IgA, and 8% for IgM in patients with definite bone marrow invasion. An increase in bone marrow Ig-secreting cells of the same Ig class that is detected on the surface of lymphoma cells and that is consistent with the concentration of the same serum monoclonal Ig is considered to indicate the presence of metastatic lymphoma cells in the bone marrow. A decrease in the percentage of bone marrow IgA-secreting cells was a consistent feature in patients with definite bone marrow invasion.

Antibodies, Monoclonal↗
PubMed1986

Non-Hodgkin's lymphoma following Hodgkin's disease. A case report and immunohistochemical corroboration.

Two non-Hodgkin's lymphomas, one a follicular mixed cell type and the other a diffuse large cell type (Working Formulation), appeared 7 and 12 years, respectively, after the initial histopathologic diagnosis of Hodgkin's disease (nodular sclerosis) in an elderly male. The clinicopathologic implications of non-Hodgkin's lymphoma complicating Hodgkin's disease as a second malignant neoplasm are discussed on the basis of immunohistochemical studies performed on the sequentially biopsied lymph nodes using various monoclonal antibodies, in particular, anti-Leu-M1, which is known as a valuable marker of the neoplastic cells of Hodgkin's disease.

Antibodies, Monoclonal↗
PubMed1985

Quantification of ferritin-secreting cells in patients with non-Hodgkin's lymphoma.

Ferritin secretion in patients with hematological malignancies, particularly malignant lymphomas, were evaluated in terms of circulating ferritin-secreting cells (FSC). There was a positive correlation between the tumor cell mass and the number of FSC, particularly monocytic FSC, but lymphoma cell suspensions contained very few FSC in comparison with the expected number. These results indicate that lymphoma cells per se may not be responsible for ferritin synthesis and secretion and suggest that ferritin synthesis and secretion in the reticuloendothelial system may be increased as a nonspecific response.

Cell Count↗
PubMed1979

Interferon susceptibility of various cell lines persistently infected with haemagglutinating virus of Japan (HVJ).

Various cell lines persistently infected with para-influenza 1 virus, HVJ strain, were less susceptible to the antiviral action of interferon than the same cell lines when not infected with HVJ. When Vero cells persistently infected with a temperature-sensitive strain of HVJ were incubated at 38 degrees C, a non-permissive temperature, they became fully susceptible to interferon, whereas neither the haemadsorbing nor the cell-associated haemagglutinating activity of the virus was expressed. These findings suggest that the lowered interferon susceptibility of virus-carrier cells may be related to the maturation of virus in them. It was found that the low susceptibility of virus-carrier cells to interferon is not due to blocked adsorption of interferon or to inability of the cells to respond tointerferon. Studies with actinomycin D suggest that some step (or steps) before the synthesis of the messenger RNA for the antiviral protein is blocked.

Animals↗
PubMed1979

Immune interferon produced in vitro as a quantitative indicator of cell-mediated immunity.

The present study was constructed to provide some information on the possibility of utilizing immune interferon as a quantitative indicator of cell-mediated immunity and to clarify some of the nature of immune interferon-producing cells (IIPC). When spleen cells derived from L cell-sensitized mice were co-cultivated with L cells, interferon appeared in the culture fluid. It was shown by additional experiments that the cells responsible for immune interferon production in this system were T-lymphocytes assisted by macrophages. The pattern of kinetics of immune interferon production in vitro was similar to that of migration inhibitory factor or T cell-mediated cytotoxicity.

Animals↗