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Biomedical subjects

A Kurien

Publications and source records attributed to A Kurien.

5 recordsLinked to original sources
PubMed2000

The bone marrow in Hodgkin's disease--a two year study.

A total of forty bone marrow trephine biopsies and aspirates were studied from thirty five patients suffering from Hodgkin's disease during the two year period 1994 and 1995. Of these twenty five were at the time of diagnosis of the disease and fifteen after treatment. The biopsies were studied for incidence of involvement as well as associated findings in both the positive and negative biopsies. A comparison of the trephine biopsy with marrow aspirate with respect to yield of positivity was made. Five patients (20%) at the time of diagnosis and two (13.33%) after treatment showed involvement of the marrow. None of the seven corresponding aspirates were positive for involvement showing that biopsies were superior to aspirates in detecting marrow infiltration in Hodgkin's disease. Suppression of the marrow, fibrosis and lymphocytic aggregates were the other findings in positive biopsies. Eosinophilia and myelosuppression were notable changes in the negative biopsies. One biopsy also showed granulomas. The probable significance of these findings are also discussed.

Adult↗
PubMed1997

Hypertension secondary to progressive vascular neurofibromatosis.

A 4 year old girl with neurofibromatosis type 1 (NF1) was referred for hypertension. An aortogram showed narrowing of the left main renal artery. An angiogram three and a half years later showed coarctation of the abdominal aorta. She underwent aortoplasty but the stenosis recurred. Vascular involvement in NF1 may be progressive and requires long term follow up.

Aorta, Abdominal↗
PubMed1997

Seasonality and other epidemiological features of haemolytic uraemic syndrome and E. coli O157 isolates in Scotland.

The main objective was to determine whether there was seasonality in presentation of haemolytic uraemic syndrome (HUS) in children and adults, and compare this with the reporting of E. coli O157. The data came from Scotland, examining admissions during 1980-95 and E. coli isolates 1984-95. Seasonality was sought by fitting a sine curve to monthly or four-weekly data throughout the year. Seasonality was present for HUS and E. coli isolates in patients under 15 years of age but not in those above that age. The highest point of the sine curve was in July/August but there was a high plateau from June to September. The timing was similar to other diarrhoeal disease. This is an epidemiological study, the purpose being to clarify the seasonal features of HUS. E. coli infection is an important food hazard and a sound knowledge of the epidemiology, could lead to optimal control. The Scottish geographic distribution is illustrated.

Adolescent↗