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Biomedical subjects

A L Berman

Publications and source records attributed to A L Berman.

At least 19 recordsLinked to original sources

Outpatient standards of care and the suicidal patient.

This article is a review of the legal and clinical literature on standards of care for nonhospitalized adult suicidal patients. The authors discuss effective assessment, management and treatment procedures that balance the need for high-quality care by a reasonable and prudent practitioner with the requirements of court-determined and statutory standards. Through a review of malpractice claims data and through an examination of the clinical literature we detail the essential guidelines for sound assessment, intervention, and management procedures. The authors specifically discuss common failure situations in outpatient care (e.g., problems in pharmacotherapy, the decision to hospitalize, inappropriate and dual relationships, the assessment of imminence and lethality, and so on). Details regarding practical considerations in developing an outpatient standard of care are provided, as are suggestions that such a standard of care must include an ongoing assessment of the therapeutic alliance.

Female

Case consultation: Mary Catherine.

A case of the attempted suicide of a 66-year-old female is presented. Comment based on the chapters in this volume is presented. Specific topics of demographics, psychiatric-psychological, object relations, the attempt, and concluding comments provide an idiographic illustration of suicidal behavior in an older adult.

Aged

Physicochemical properties of signal receptor domains as the basis for sequence comparison.

1. An algorithm of sequence comparison based on average bulkiness of amino acids in protein domains and not requiring sequence alignment is described. 2. A complete evolutionary tree of the signal receptor proteins is built. The STE2 proteins are shown to belong to this family. 3. Factorial analysis of average bulkiness makes it possible to discriminate functional and intraspecies differences between proteins.

Algorithms

Empirical criteria for the determination of suicide manner of death.

A 16-item instrument was constructed as a tool to assist medicolegal official in their investigations and certifications of suicidal deaths. The Empirical Criteria for the Determination of Suicide (ECDS)--derived from a combined set of the 22 criterion items of the Operational Criteria for the Determination of Suicide (OCDS) and 33 other items obtained from experts and the professional literature--was constructed and validated by using 126 suicide and accident cases obtained from 70 medical examiner participants. Analysis of the cases confirmed that suicide is a manner of death in which there is evidence of both self-infliction and intention to die. The 16 items retained in the ECDS discriminated suicides from accidents best in relation to self-infliction and intention. In analysis of its concurrent validity, the ECDS instrument predicted 100% of the suicides and 83% of the accidents, thus correctly identifying 92% of all cases.

Cause of Death

Suicide cases.

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Adolescent

Suicide attempts among adolescent drug users.

Substance use has been identified as a significant risk factor in nonfatal and fatal suicides during adolescence. A comprehensive questionnaire on patterns of alcohol and other drug use, early childhood and nuclear family psychological and behavioral history, and previous suicidal attempts was completed by 298 (88%) of 340 outpatient adolescent substance abusers in three geographic regions east of the Mississippi River. An abbreviated Beck Depression Inventory was included to ascertain current symptoms of depressed mood. Adolescents admitting to a previous suicide attempt (30%) were compared with two age- and sex-matched samples. Substance abusers were three times as likely as a normative population of non-drug-using age- and sex-matched peers to make a suicide attempt. Thirty-three percent of attempts reported occurred prior to high school. Both the wish to hurt oneself and actual suicide attempts were found to increase significantly after the initiation of substance use. Forty percent used drugs within 8 hours before the suicide attempt, and 23% of attempters reported that their families continued to have a firearm with ammunition in the home following the suicide attempt. Adolescent substance abusers who had attempted suicide were significantly more likely than a matched group of nonattempters in the same drug treatment facility to: (1) complain of usually feeling "blue" or sad (depressed affect) during early childhood, (2) identify important childhood behavioral problems, (3) identify long-standing self-perceived impaired self-concept, and (4) identify serious parental problems, such as chronic depression or alcoholism. Self-perceived chronic loneliness in childhood appears to be a singularly important initiator of adolescent drug use and subsequent suicide attempts among drug abusers.

Adolescent

The Miltons.

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Adaptation, Psychological

[Study of thermo-stabilizing effect of tocopherol on rhodopsin in the presence of fatty acids using the method of differential scanning calorimetry].

By the method of differential scanning calorimetry it was shown that the addition of arachidonic acid to photoreceptor membranes is accompanied by concentration-dependent shift of thermograms curve of rhodopsin value. Addition of tocopherol to photoreceptor membranes prevents the turbulent effect of the fatty acid on opsin and rhodopsin. The obtained data are discussed from the point of view of membrane protective properties of tocopherol.

Arachidonic Acid

Dyadic death: murder-suicide.

Twenty homicide-suicides, drawn from death records of three major eastern United States cities, were analyzed in comparison to prior studies and samples of homicide offenders and suicide victims. Results indicated a lower incidence for this event than reported previously and several distinguishing characteristics of the murderer who subsequently commits suicide. Two primary types, from the perspective of ego fusion, are discussed.

Adult

[Protein inhibitor of the retinal cyclic nucleotide phosphodiesterase: its localization in the outer segment of a photoreceptor].

The content of a protein inhibitor of the cyclic nucleotides phosphodiesterase (PDE) in different retinal preparations as well as its distribution in the subfractions of rod outer segments (ROS) was studied. The content of protein inhibitor of PDE in different preparations of the retina was found to correlate with the rhodopsin content. The distribution of this protein over different ROS subfractions appeared to be exactly the same as that of rhodopsin, the content of protein inhibitor of PDE being more than a half of its content in the native ROS. The protein inhibitor of PDE could be easily washed out from the ROS fractions. It is concluded that the cattle protein inhibitor of PDE is localized in ROS, and is absent in the other retinal layers.

Animals

[Modification of retinal photoreceptor membranes and Ca ion binding].

Calcium binding by modified photoreceptor membranes of cattle retina has been studied. Ca2+-binding the membranes significantly changes after C-phospholipase treatment, displaying the initial growth (less than 65% of lipid phosphorus removed) with subsequent decrease (more than 65% of phosphorus removed). Liposomes of the photoreceptor membranes lipids were found to bind more calcium than do the native photoreceptor membranes. Proteolytic enzymes (papaine, pronase) splitting some rhodopsin fragments do not affect the ability of the membrane to bind Ca2+. The increase of light-induced Ca-binding is observed only after the outer segments preincubation under conditions providing for rhodopsin phosphorylation. This effect was observed also after the splitting of the rhodopsin fragment by papaine. It is concluded that calcium binding in the photoreceptor membranes is mainly due to the phosphate groups of phospholipids.

Animals