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Biomedical subjects

A L Bezerra

Publications and source records attributed to A L Bezerra.

8 recordsLinked to original sources
PubMed2001

Human papillomavirus as a prognostic factor in carcinoma of the penis: analysis of 82 patients treated with amputation and bilateral lymphadenectomy.

BACKGROUND: Many studies have tried to identify prognostic factors to guide the selection of patients at high risk for metastases in penile carcinoma. The authors evaluated human papillomavirus (HPV) status with respect to clinical features, incidence of metastases, and prognosis of penile carcinoma. METHODS: Human papillomavirus DNA was detected using the polymerase chain reaction on paraffin embedded material from 82 patients with penile carcinoma. The following variables were recorded: age, marital status, clinical staging, tumor surgery extension, histologic grade, tumor thickness, lymphatic and venous embolization, corpora cavernosa and corpus spongiosum infiltration, urethral infiltration, mononuclear and eosinophilic infiltrate, and lymph node spread. Follow-up ranged from 0.1 to 453 months. RESULTS: Human papillomavirus DNA was detected in 30.5% (25 of 82) of samples. HPV-16 was the most frequent type detected (13 of 25, 52%). Human papillomavirus DNA positive tumors had less lymphatic embolization by neoplastic cells than HPV negative ones (P = 0.007). The logistic regression revealed that only lymphatic embolization was related to HPV status. There was no difference, however, between HPV DNA negative and HPV DNA positive patients according to presence of lymph node metastases (P = 0.386). No difference was found in the 10-year survival rate (68.4% vs. 69.1%; P = 0.830) between the two groups. CONCLUSIONS: These data suggest that HPV status does not influence prognosis in invasive penile carcinoma.

Adult↗
PubMed2001

Clinicopathologic features and human papillomavirus dna prevalence of warty and squamous cell carcinoma of the penis.

Squamous cell carcinoma (SCC) accounts for 95% of penile malignant neoplasms. A subtype of SCC, named warty carcinoma (WC), is a morphologically distinct verruciform tumor with features of human papillomavirus (HPV)-related lesions. Descriptions of the behavior and histologic features of this tumor are scarce in the literature. The aim of this report is to analyze the clinicopathologic features and HPV deoxyribonucleic acid status in 60 SCCs and 11 WCs. The mean patient age was 46.5 +/- 15.9 years for WC and 52.6 +/- 12.4 years for SCC. No significant differences in age (p = 0.154) and clinical staging (T, p = 0.649; N, p = 0.497) between the two groups of tumors were found. When compared with SCCs, WCs exhibited less lymphatic embolization (p = 0.001), nodal metastasis (p = 0.019), and corpora cavernosa and corpus spongiosum infiltration (p = 0.040). Lymph node metastases were found in 34 of 60 SCC patients (56.7%) and in two of 11 WC patients (18.2%). No patients with WC tumors died of the disease compared with 19 of 60 (5-year specific survival, 66.0%) in the SCC group (p = 0.032). HPV deoxyribonucleic acid was more likely to be associated with WC (five of 11, 45.5%) than SCC (16 of 60, 26.7%), although significance was not reached (p = 0.209). The results suggest that WC is less aggressive and confers a better prognosis than typical SCC of the penis.

Adult↗
PubMed2000

Iliac nodal metastases from carcinoma of the penis treated surgically.

OBJECTIVE: To evaluate survival in patients with metastatic iliac nodal involvement from carcinoma of the penis. PATIENTS AND METHODS: Thirteen patients with metastases to the iliac nodes were selected from 68 with squamous cell carcinoma of the penis who had undergone amputation and bilateral ilio-inguinal lymphadenectomy. The 1978 Tumour-Nodes-Metastasis system was used for staging. Deep and superficial lymph nodes were removed during the inguinal procedure. Lymph nodes below the common iliac artery (external and obturator) were removed and histologically evaluated for the presence of metastases. RESULTS: The mean (median, range) follow-up was 55.5 (8. 8, 0.3-235) months, at the end of which five patients were free of cancer, seven had died from cancer or treatment-related complications and one was lost to follow-up. Four of the five survivors had metastases to only one iliac lymph node. CONCLUSION: Ilio-inguinal lymphadenectomy may have a significant role in increasing the survival of patients with metastases to only one iliac lymph node.

Adult↗
PubMed1998

[Gestures and postures of nurses during the orientation of families of patients in intensive care].

This study was done to evaluate nurses postures and gestures when patient and family orientation was being done in an Intensive Care Unit. Data were colected using filming of nurse, patient and family interaction. Gestures were classified as by Ekman and Friesen. It was seen predominance of ilustrative gestures, wich was positive, as those types of gestures reinforce the object of the nurse talk and enhance comprehension by families.

Critical Care↗
PubMedDate not supplied

A contribution of the mitochondrial adenosinetriphosphatase inhibitor protein to the thermal stability of the F0F1-ATPase complex.

A complete inactivation is observed after a 3 min pre-incubation at 70 degrees C with mitochondrial F0F1-ATPase complex depleted of the ATPase natural inhibitor protein (ammonium-Sephadex submitochondrial particles) and activated MgATP-submitochondrial particles (particles that after a 4 h-pre-incubation at 42 degrees C released the endogenous inhibitor protein). However, latent MgATP-submitochondrial particles (particles containing the inhibitor protein) pre-incubated under the same conditions are totally inactivated only after 15 min of pre-incubation. When ammonium-Sephadex particles are reconstituted with 20 micrograms/ml of purified ATPase inhibitor protein there is an increase of 15-fold in the half-time for thermal inactivation (t0.5), showing that the inhibitor protein protects the mitochondrial F0F1-ATPase complex against thermal inactivation.

Adenosine Triphosphate↗
PubMedDate not supplied

[Reasons for personnel turnover in a private health facility].

This study was done in a Sao Paulo city hospital with 54 nurses who required for dismissal from January, 1995 to January, 1996. All of them at the dismissal interview provided information on how long they had worked for the hospital, reasons for leaving and their frank opinions about the hospital itself, nurse department directors and personal suggestions. The study goal was to evaluate the reasons for high turnover of institutions nurses in order to draw adequate administrative intervention strategies. An exploratory study of retrospective character with data quantitative qualitative analysis has been used. Data analysis considered that 74% of the nurses had left the institution in 12 months but 35.3% until the third month. The nurses emphasized work conditions specially the staff, benefits and interpersonal communication. The results came towards our perception on the institution nurses turnover causes.

Brazil↗
PubMedDate not supplied

Classification for nursing practice in Brazil.

The nursing activities--diagnosis, intervention and client outcome-have several synonyms, different meanings and antagonistic frame-works. Although the study results can be considered as potential barriers to the Classification for Nursing Practice project in Brazil, or anywhere else, they also indicate a high number of references related to this theme, leading us to conclude that there is motivation for defining and classifying nursing phenomena.

Brazil↗