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Biomedical subjects

A L Boyer

Publications and source records attributed to A L Boyer.

At least 19 recordsLinked to original sources

Dose distributions of x-ray fields as shaped with multileaf collimators.

Multileaf collimators (MLC) with various blade widths were simulated using standard cerrobend blocks, and three-dimensional dose computations were carried out to study the resultant radiation field edges. Film measurements made with 6 and 18 MV x-ray beams were compared with calculations that employed a three-dimensional Fourier convolution. A spatial accuracy of better than 3 mm was found in the 50% isodose line of the penumbral region with a calculation voxel size of 5 mm x 5 mm x 5 mm. The computer simulation was used to study the deviation of the calculated 50% isodose line from the desired geometric field edge using various MLC blade positions. The study suggests that multileaf collimation to the outside of the desired field edge will lead to overdose outside the field, whereas multileaf collimation to the inside of the desired field edge will lead to underdose inside the field. When the direction of travel of the leaves with respect to the field edge is near 45 degrees, the 50% isodose of a multileaf-collimated beam will fall close to the desired edge with no underdose when the leaf corners are allowed to insert into the desired field edge by 1.2 mm for 6 MV x-rays and 1.4 mm for 18 MV x-rays using a 1 cm wide leaf. These blade offsets account for the scattering of photons and electrons in the medium within the penumbral region.

Computer Simulation

Dosimetry characteristics of metallic cones for intraoperative radiotherapy.

Dosimetry data were obtained on the first dedicated linear accelerator of its type designed for electron intraoperative radiotherapy (IORT) within an operating room. The linear accelerator uses a high dose rate, 9 Gy.min-1, to reduce the treatment time. Its chrome-plated brass treatment cones, designed with straight ends and 22.5 degrees beveled ends, are not mechanically attached to the collimator head, but are aligned using a laser projection system. Dosimetry measurements were made for each combination of energy (6, 9, 12, 15, and 16 MeV), cone size (diameters range from 5 to 12 cm), and cone type (22.5 degrees beveled or straight). From these data, depth-dose curves, cone output, and air-gap correction factors were generated that allow the calculation of the monitor setting for delivering a prescribed dose at any depth for any irradiation condition (energy, cone, air gap). Isodose data were measured for every cone using film in a solid water phantom. Scatter off the inside wall of the cone resulted in peripheral dose horns near the surface that were energy and cone dependent, being as large as 120%.

Electrons

Dose-response characteristics of a ferrous-sulphate-doped gelatin system for determining radiation absorbed dose distributions by magnetic resonance imaging (Fe MRI).

The nuclear magnetic resonance (NMR) longitudinal relaxation rate R1 dose-response characteristics of a ferrous-sulphate-doped chemical dosimeter system (Fe MRI) immobilized in a gelatin matrix were explored. Samples containing various concentrations of the FeSO4 dosimeter were irradiated to absorbed doses of 0-150 Gy. R1 relaxation rates were determined by imaging the samples at a field strength of 1.5T(1H Lamor frequency of 63.8 MHz). The response of the system was found to be approximately linear up to doses of 50 Gy for all FeSO4 concentrations studied (0.1-2.0 mM). Changing concentrations in the range of 0.1-0.5 mM affected both the slope and intercept of the dose-response curve. For concentrations of 0.5-2.0 mM, the slope of the dose-response curves remained constant at approximately 0.0423 s-1 Gy-1 in the dose range of 0-50 Gy. However, the intercept of the curve continued to increase in that region, as expected, because of the additional paramagnetic ions. The reproducibility of the absorbed dose estimates for measurements made over a 22 cm field of view was found to be 5% in the range of 20-50 Gy (an uncertainty of 0.81 Gy on average), decreasing to approximately 10% in the dose range of 5-10 Gy.

Dose-Response Relationship, Radiation

Shielding considerations for an operating room based intraoperative electron radiotherapy unit.

The leakage radiation characteristics of a dedicated intraoperative radiotherapy linear accelerator have been measured on a machine designed to minimize the shielding required to allow it to be placed in an operating room suite. The scattering foil design was optimized to produce a flat beam for the field sizes employed while generating minimal bremsstrahlung contamination over the available energy range. More lead shielding was used in the treatment head than is used in conventional accelerators. A small amount of borated polyethylene shielding was also employed since neutron production was present at measurable levels. The room shielding installed in the operating room was demonstrated to be adequate to treat at least 20 patients each month to an average dose of 20 Gy. The worst case exposure was found to be 73% maximum permissible exposure. Administrative control was required for adjoining areas when calibrations and maintenance were performed.

Intraoperative Period

Design of metallic electron beam cones for an intraoperative therapy linear accelerator.

A set of circular collimators and treatment cones from 5 to 12 cm diameter has been designed for an intraoperative accelerator (6-18 MeV) that has an optical docking system. Electron beam scattering theory has been used to minimize their weight while minimizing leakage radiation. Both acrylic and brass were evaluated as possible materials; however, because of substantial electron leakage through the lateral cone wall for acrylic, we have concluded that 2 mm thick brass walls are more desirable than acrylic walls. At 18 MeV, isodose measurements beneath the cones showed hot spots as great as 120% for both materials. The placement and dimension of an internal trimmer ring inside the brass cone was studied as a method for reducing the hot spots, and it was found this could only be accomplished at the expense of decreasing coverage of the 90% isodose surface. The effects of 1 degree cone misalignment on the dose distribution has been studied and found to generate changes of less than 5% in the dose and 3 mm in position of the 90% isodose surface. In a study of the contribution of the cone and its matching collimator assembly to x-ray room leakage, it was noted that although the treatment cone had a negligible contribution, the upper annuli of the upper collimator assembly contributed as much as 80% of the leakage at 16 MeV for the 5-cm cone.

Humans

Effects of dosimetric and clinical uncertainty on complication-free local tumor control.

A mathematical description is developed to demonstrate the effects of uncertainty on complication-free local tumor control. Responses of tumors and normal tissues are modeled by conventional radiobiological models. Uncertainties are considered in the delivery of absorbed dose to the target volume and the normal tissue at risk for complications. The degree by which uncertainties compromise complication-free local control for target volumes with various tumor cell burdens is calculated.

Computer Simulation

Relationship between attenuation coefficients and dose-spread kernels.

Dose-spread kernels can be used to calculate the dose distribution in a photon beam by convolving the kernel with the primary fluence distribution. The theoretical relationships between various types and components of dose-spread kernels relative to photon attenuation coefficients are explored. These relations can be valuable as checks on the conservation of energy by dose-spread kernels calculated by analytic or Monte Carlo methods.

Radiometry

Backscatter radiation at bone-titanium interface from high-energy X and gamma rays.

Occasionally head and neck cancer patients treated with high-energy X rays and gamma rays have titanium metal dental implants in their maxillae or mandibles. The resulting effect of the bone-metal interface on the radiation dose is of interest. Ionization measurements for 60Co gamma rays and 6 MV and 25 MV X rays were made. A thin-window parallel-plate chamber was used to determine the magnitude of the dose enhancement that was due to the backscattered electrons from titanium. The results showed that for 60Co there is a 15% increase in dose to solid bone at the entrance side of the titanium. For higher energy X rays, the increase in dose was about the same or slightly lower than for 60Co. Monte Carlo calculations substantiated the measurements. This increase in dose fell off rapidly and became negligible at 1-2 mm from the interface. This backscattered dose should be taken into account when planning radiation therapy treatment for patients with dental implants.

Bone and Bones

Laser "cross-hair" sidelight.

A technique is described for forming an optical laser cross-hair image for use as a radiotherapy sidelight. The technique is developed from a concept introduced earlier by which a line image is formed from a laser beam using a cylindrical lens. By using two cylindrical lenses and appropriate reflectors, two line images can be made to form a cross.

Humans

A fundamental accuracy limitation on measurements of brachytherapy sources.

The dose rate gradients in the first few centimeters away from brachytherapy sources are extremely high. Attempts at direct measurements of the dose rates in the near vicinity of such sources are made with the smallest detectors available. Nevertheless, it is not obvious that the agreement between reported measurements and theoretical calculations can be justified when the dose rate gradients across the detector volumes employed are so great. A figure of merit is derived here which indicates how well the dose averaged over the volume of the detector corresponds to the dose at the center of the detector. This figure of merit provides a means to assess the maximum accuracy one can expect to achieve in a measurement made at a given distance from a linear source based on the dimensions of the source and the dimensions and shape of the detector.

Brachytherapy

Encoding patient contours using Fourier descriptors for computer treatment planning.

Frequently it is desirable to digitize patient's external and internal contours from computer-assisted tomography (CAT) scan images and to use them for computer treatment planning. After the contours are digitized, each contour could contain over 1000 points. It is a common practice to reduce the number of contour points by interpolation methods in order to use them in a treatment planning program, and in order to save storage space. This paper describes an alternative method for encoding contours. The x-y coordinates of each contour point are represented as a complex number, x + jy. The discrete Fourier transform (DFT) of the array of complex numbers is then computed. Only the 50 lowest frequency components of the DFT are retained. Each contour is then represented by these 50 complex numbers, known as Fourier descriptors. The original contour is restored by performing the inverse Fourier transform. All the frequency components higher than 50 are assumed to be zero during the inverse Fourier transform. The algorithm is described in detail.

Computers

Calculation of photon dose distributions in an inhomogeneous medium using convolutions.

A formulation of the single energy photon transport problem is cast in the form of a series of convolutions over the primary fluence distribution with invariant kernels. A method is developed for compensating for the variant intervoxel attenuation in the scattered dose distribution by means of an invariant correction kernel. Results of applying the formulation to 60Co distributions in the presence of slab and block inhomogeneities are presented.

Cobalt Radioisotopes

Brachytherapy seed dose distribution calculation employing the fast Fourier transform.

A mathematical procedure is described by which the dose distribution of a seed implant can be calculated employing a Fourier transform. The procedure is described in one-, two-, and three- dimensional representations. Dose distributions calculated using this technique are demonstrated. Mathematical constraints of the procedure are discussed.

Brachytherapy

A comparison of the speeds of three convolution algorithms.

The speeds of three computer algorithms suitable for use in three-dimensional radiotherapy planning codes were compared. Two of the algorithms are based on ray-tracing methods, the first algorithm uses a fast ray-tracing procedure directly and the second employs a table lookup procedure; the table was originally calculated by ray tracing. The third algorithm was a convolution procedure using the fast Fourier transform. Benchmark programs were written to compare the fundamental running speeds of the three algorithms operating on three-dimensional arrays of various sizes. The convolution procedure employing the three-dimensional fast Fourier transform had the shortest running times on a VAX/750 (Digital Equipment Corp.) computer. We concluded that this algorithm holds significant potential for practical three-dimensional dose calculations.

Algorithms

Calibration frequency as determined by analysis of machine stability.

Simple statistical analysis is applied to the evaluation of the output measurements of equipment used in radiotherapy. The calibration frequency is calculated based on the stability of the equipment and the performance parameters required by the quality control criteria.

Calibration