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Biomedical subjects

A L Dellon

Publications and source records attributed to A L Dellon.

At least 19 recordsLinked to original sources
PubMed2006

The innervation of the medial humeral epicondyle: implications for medial epicondylar pain.

The purpose of this study was identification of the innervation of the medial humeral epicondyle which has not been described before. In 20 patients, the medial intermuscular septum was evaluated histopathologically: the nerve was identified in 15 specimens without S-100 staining, and in the remaining 5 with S-100 staining. In six fresh cadavers, bilateral dissections identified the source of this nerve as the radial nerve in the axilla, coursing adjacent to the ulnar nerve in the upper arm, then moving laterally to be superficial to, or within, the medial intermuscular septum, until the nerve terminated in the periosteum of the medial humeral epicondyle, at the origin of the flexor-pronator muscle mass. In one specimen, a branch from the ulnar nerve in the axilla contributed to this nerve to the medial humeral epicondyle.

Cadaver↗
PubMed2001

Correction of scapular winging by supraclavicular neurolysis of the long thoracic nerve.

Injury to the long thoracic nerve results in winging of the scapula. When there is no known direct site of injury to this nerve, the traditional treatment consists of bracing the shoulder and, if recovery of function does not occur, then carrying out a muscle transfer to reconstitute the forces required to bring the scapula into appropriate position with respect to the thorax. The present report describes four patients in whom a site of compression of the long thoracic nerve within the scalene muscles proved to be the site of compression. A supraclavicular neurolysis of the long thoracic nerve resulted in correction of the winged scapula in all four of these patients.

Adult↗
PubMed2001

Experimental model of pyridoxine (B6) deficiency-induced neuropathy.

A pyridoxine (B6) dietary deficiency was studied in female adult Sprague-Dawley rats by hind-limb walking-track analysis. Serum levels of pyridoxine and three metabolites were quantified by high-pressure liquid chromatography with fluorescence measurement. Morphometric analysis of the sciatic and posterior tibial nerves (from within the tarsal tunnel) was performed after 1 year on a diet deficient in vitamin B6. The B6-deficient rats developed abnormal walking-track patterns by 8 months, and these track parameters were different from age- and sex-matched normal diet control rats at the p < 0.05 level. Adding B6 at 10 parts per million to the diet then partially corrected these parameters, whereas the addition of 30 parts per million B6 corrected the abnormal pattern completely. Serum pyridoxal concentration correlated with the functional parameters, dropping from a mean of 115 mg per liter to 39.5 mg per liter (p < 0.05), and correcting with the B6 additive. Morphometric analysis demonstrated that the B6-deficient nerve from the tarsal tunnel had a decreased nerve fiber density (p < 0.001), with a normal total myelinated nerve fiber number, and an increased axon-to-myelin ratio (p < 0.003). It is concluded that a diet totally deficient in vitamin B6 results in a peripheral neuropathy.

Animals↗
PubMed2001

Innervation of the sinus tarsi and implications for treating anterolateral ankle pain.

Anterolateral ankle pain can persist despite the best care of sprains or fractures. It is possible that this pain is related to stretch or traction injuries to the nerves that innervate the subtalar joint. If this were true, identification of these nerve branches by local anesthetic block would provide an indication that surgical interruption of the function of these nerves may provide pain relief. In 28 feet of 14 cadavers (7 male/7 female), investigation of the deep peroneal nerve demonstrated a consistent pattern whereby a series of 2 to 4 (mean, 2.9 +/- 0.6) branches innervated the anterolateral part of the subtalar joint. All these nerve branches originated from the lateral terminal branch of the deep peroneal nerve on the dorsum of the foot. The mean distance between the exit of the first articular branch and the exit of the terminal motor branch both originating from the lateral terminal branch was 3.8 +/- 1.1 cm. The motor branch passed under the extensor digitorum brevis muscle at a mean distance of 5.3 +/- 0.6 cm from the tip of the lateral malleolus. The presented anatomy provides a basis for the diagnosis and treatment of persistent anterolateral ankle pain of neural origin.

Ankle Joint↗
PubMed2001

Anatomic variability of the ilioinguinal and genitofemoral nerve: implications for the treatment of groin pain.

The differential diagnosis of groin pain must consider problems of the ilioinguinal and/or genitofemoral nerve. These nerves may become injured during hernia surgery or lower quadrant surgical procedures. To treat injury to these nerves, it is critical to understand their anatomic variability. In the present study the pattern of cutaneous nerve branches in the inguinal region was investigated through dissection in 64 halves of 32 human embalmed anatomic specimens. In contrast to usual textual descriptions, four different types of cutaneous branching patterns are identified: type A, with a dominance of genitofemoral nerve in the scrotal/labial and the ventromedial thigh region. In type A, the ilioinguinal nerve gives no sensory contribution to these regions (43.7 percent). In type B, with a dominance of ilioinguinal nerve, the genitofemoral nerve shares a branch with the ilioinguinal and gives motor fibers to cremaster muscle in the inguinal canal, but has no sensory branch to the groin (28.1 percent). In type C, with a dominance of genitofemoral nerve, the ilioinguinal nerve has sensory branches to the mons pubis and inguinal crease together with an anteroproximal part of the root of the penis or labia majora. The nerve was found to share a branch with the iliohypogastric nerve (20.3 percent). In type D, cutaneous branches emerge from both the ilioinguinal and the genitofemoral nerves. Additionally, the ilioinguinal nerve innervates the mons pubis and inguinal crease together with a very anteroproximal part of the root of the penis or labia majora (7.8 percent). The described patterns of innervation were bilaterally symmetric in 40.6 percent of the cadavers. The anatomic variability of both nerves has implications for all surgeons operating in the groin region and for those caring for the patient with groin pain.

Abdomen↗
PubMed2001

Augustus V. Waller and plastic surgery.

Augustus V. Waller's name is associated eponymously with the regressive changes in transected nerves. This article intends to present the many other aspects of Waller's scientific ventures. Apart from pioneering intravital microscopy, Waller made significant contributions to the understanding of the process of tissue inflammation. In addition to his observations of the degenerative changes in severed nerve fibers, he developed a concept of trophic dependence that is relevant for the management of the regeneration of peripheral nerves in plastic surgery.

England↗
PubMed2001

Neuromas of the calcaneal nerves.

A neuroma of a calcaneal nerve has never been reported. A series of 15 patients with heel pain due to a neuroma of a calcaneal nerve are reviewed. These patients previously had either a plantar fasciotomy (n = 4), calcaneal spur removal (n = 2), ankle fusion (n = 2), or tarsal tunnel decompression (n = 7). Neuromas occurred on calcaneal branches that arose from either the posterior tibial nerve (n = 1), lateral plantar nerve (n = 1), the medial plantar nerve (n = 9), or more than one of these nerves (n = 4). Operative approach was through an extended tarsal tunnel incision to permit identification of all calcaneal nerves. The neuroma was resected and implanted into the flexor hallucis longus muscle. Excellent relief of pain occurred in 60%, and good relief in 33%. One patient (17%) had no improvement and required resection of the lateral plantar nerve. Awareness that the heel may be innervated by multiple calcaneal branches suggests that surgery for heel pain of neural origin employ a surgical approach that permits identification of all possible calcaneal branches.

Adult↗
PubMed2001

Pain at the site of tarsal tunnel incision due to neuroma of the posterior branch of the saphenous nerve.

The authors conducted a retrospective review of 16 patients who presented with the complaint of pain at the incision site after tarsal tunnel decompression. Specifically, the pain was located at the proximal aspect of the tarsal tunnel decompression scar. The mean duration of pain was 21 months (range, 6 to 34 months). The pain was eliminated by a block of the distal saphenous nerve, demonstrating that the pain was due to a neuroma of this nerve. The pain was treated by resection of the distal saphenous nerve in the distal leg and implantation of the proximal end of this nerve into the soleus muscle. At a mean of 18.5 months after surgery (range, 6 to 33 months), excellent relief of pain was achieved in 76% of cases and good relief of pain in 24% of cases.

Decompression, Surgical↗
PubMed2001

Clinical grading of peripheral nerve problems.

To treat peripheral nerve problems appropriately, and to evaluate outcomes of peripheral nerve surgery, it is necessary to be able to stage the degree of nerve impairment. This article describes quantitative sensory testing that permits the necessary measurements for clinical grading of peripheral nerve functions.

Cubital Tunnel Syndrome↗
PubMed2000

Surgical management of groin pain of neural origin.

BACKGROUND: An approach to surgical management of the patient with groin pain is described based on our experience with 54 patients, six of whom had bilateral symptoms. History and physical examination are sufficient to relate the pain to one or more of the lateral femoral cutaneous (LFC), ilioinguinal (II), iliohypogastric (IH), or genitofemoral (GF) nerves. STUDY DESIGN: Retrospective analysis of patients with groin pain is reported, with emphasis on cause, involved nerves, and outcomes of operative management. The LFC was decompressed. The II, IH, and GF nerves were resected. Outcomes were graded as excellent, good, and poor in terms of pain relief and functional restoration. RESULTS: For the entire series of patients with painful groins, excellent relief of pain was achieved in 68% and restoration of function achieved in 72%. Ten percent had a poor result. The best results were for II and IH, which were 78% and 83% excellent for both pain relief and restoration of function, with 11% and 17% having a poor result, respectively. The worst results were for the small group of patients with a GF problem, 50% of whom had an excellent and 25% a poor result. Patients who were likely to get an LFC entrapment were those with a nerve located above or within the inguinal ligament. Complications included bruising and cautery injury to the LFC. CONCLUSIONS: Groin pain of neural origin can be relieved with a high degree of patient satisfaction by considering whether one or more of four different nerves are the source of that pain, by realizing that symptoms can be referred to regions other than the groin, such as the pelvic viscera (IH), the knee (LFC), and the testicle (GF), and by treating the appropriate nerve(s) by either neurolysis (LFC) or resection.

Adult↗
PubMed2000

Utility of decompressive surgery in the prophylaxis and treatment of cisplatin neuropathy in adult rats.

Cisplatin produces a dose-dependent and dose-limiting peripheral neuropathy in patients. This study tested the hypothesis that this clinical neuropathy results from the chronic compression of peripheral nerves rendered susceptible to injury because of cisplatin-induced microtubular dysfunction. A quantitative model of cisplatin neurotoxicity was developed by administering cisplatin to rats and measuring the neuropathy by hindlimb walking track assay. The study aims were: (1) to characterize neuropathy induced by cisplatin in the adult rat; (2) to evaluate the role of decompressive surgery in the prevention of cisplatin neuropathy; and (3) to determine whether decompressive surgery was an effective treatment for established neuropathy. The assay demonstrated an increased print length in animals after 8 weeks of cisplatin (p < 0.01). This neuropathy progressed for 6 weeks after cisplatin was stopped, and reversed slowly over 3 months. These abnormalities were prevented by early tarsal tunnel decompression. Decompressive surgery was also beneficial, if performed early in the course of the neuropathy; abnormalities reversed in 5 weeks and remained normal for the remainder of the study. Control animals had progressive abnormalities which slowly resolved over a period of 18 weeks after discontinuing cisplatin. However, decompressive surgery performed after the neuropathy was established did not alter the neuropathic walking-track pattern. These studies provide insight into the etiology and possible therapeutic approaches to cisplatin neuropathy. Although further studies are required, they suggest that, in selected patients, decompressive surgery may have a role in the prevention or early treatment of cisplatin-induced neuropathy. Patients with underlying clinical or subclinical compressive neuropathies could be at high risk for the development of cisplatin neuropathy, and quantitative monitoring of neuropathies may be useful.

Animals↗
PubMed2000

Results of decompression of peripheral nerves in diabetics: a prospective, blinded study.

Diabetic neuropathy traditionally is considered progressive and irreversible and will result in lower extremity ulceration and amputation in a segment of the diabetic population, despite the best efforts to control serum glucose levels. Restoration of sensation to the diabetic may prevent these complications of neuropathy. The present study was designed to evaluate whether decompression of a peripheral nerve at a known site of anatomic narrowing can restore sensibility to that nerve in the diabetic. Twenty diabetic patients ( 14 type I, 6 type II, with a mean duration of diabetes of 14.8 years) had surgical decompression of a median nerve at the wrist and an ulnar nerve at the elbow, or a decompression of the posterior tibial nerve at the ankle (total of 31 nerves). A therapist, in a manner blind to the operative site, evaluated two-point discrimination in the pulp of the appropriate digit. The postoperative sensibility was compared with that of the nontreated, contralateral extremity. At a mean of 23.3 months, 69 percent of the lower-extremity nerves and 88 percent of the upper-extremity nerves (79 percent overall) had improvement in sensibility. In comparison, 32 percent of the control (not decompressed) contralateral nerves had measurable progression of neuropathy. The hypothesis that decompression of a peripheral nerve in the diabetic will improve sensibility was confirmed at the p < 0.001 level.

Adult↗