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Biomedical subjects

A L Freinkel

Publications and source records attributed to A L Freinkel.

10 recordsLinked to original sources
PubMed1998

Primary extrarenal Wilms' tumor of the uterus presenting as a cervical polyp.

Extrarenal Wilms' tumor is rare in any site, and only three cases arising within the uterus have been reported. Two of the previous cases were in adolescent girls, appearing as polypoid vaginal masses, and the third was in a 22-year-old woman who had menometrorrhagia. An extrarenal Wilms' tumor in an 11-year-old girl that initially appeared as a 10-cm polyp protruding through the cervix is described. Triphasic differentiation with mesenchymal stroma showing rhabdomyoblastic differentiation both morphologically and immunohistochemically was demonstrated. Epithelial differentiation with focal glomerular differentiation also was present. Most of the primary tumor and almost the entire recurrent tumor were composed of blastemal cells. The diagnosis of an extrarenal Wilms' tumor should be entertained when examining a polypoid tumor of the cervix or a polypoid mass within the vagina in an adolescent patient.

Biomarkers, Tumor↗
PubMed1997

Immunohistochemical investigations of genital ulcers caused by Haemophilus ducreyi.

To gain information on the specific composition of the inflammatory infiltrate of genital ulcers caused by Haemophilus ducreyi, biopsies of 6 genital ulcers which were diagnosed as chancroid on clinical and microbiological grounds were subjected to immunohistochemical investigations after conventional haematoxylineosin staining. A variety of antibodies reactive against B- and T-cells, plasma cells and granulocytes were used with each tissue sections. The lymphocytic infiltrate of chancroid ulcers consisted of both B- and T-lymphocytes and showed a cluster-like formation. B-lymphocytes were preferentially localized perivascularly in the middle layer, T-lymphocytes mainly in the deep layer of the inflamed oedematous tissue. Results stress the importance of both B- and T-cell mediated immune responses in Haemophilus ducreyi infection.

Antibodies, Bacterial↗
PubMed1992

A serological test for granuloma inguinale.

OBJECTIVES: An indirect immunofluorescence technique applied to paraffin embedded tissue sections of lesions containing Donovan bodies was evaluated as a serological test for the diagnosis of granuloma inguinale. METHODS: Sera from patients with proven granuloma inguinale, other sexually acquired genital ulcerations and blood donors from areas where granuloma inguinale is rarely encountered as well as from disease-endemic regions were tested. Sera were tested either unabsorbed or following absorption with whole Klebsiella pneumoniae bacteria. RESULTS: Using unabsorbed sera at a dilution of 1:160 the test was found to have a sensitivity of 100%, specificity of 98%, positive predictive value (PPV) of 89% and negative predictive value (NPV) of 100%. There proved to be no advantage in preabsorbing sera with K. pneumoniae antigen. CONCLUSIONS: In the absence of culture methods for Calymmatobacterium granulomatis, an indirect immunofluorescence technique may prove valuable for the diagnosis of individual cases of granuloma inguinale and as an epidemiological tool in studies of the disease.

Antibodies, Bacterial↗
PubMed1990

The enigma of granuloma inguinale in South Africa.

Granuloma inguinale (donovanosis) was well described in South Africa in the early part of this century. After 1927 no further reports appeared and with the passage of time, the belief grew that the disease did not occur in this country. This belief held until the 1980s, when several reports of cases of the disease appeared. What happened to the disease in the intervening half century? Did it disappear spontaneously? Or was it just not being recognised even when cases were being reported from 1950 onwards in neighbouring Zimbabwe? How is it that a disease can remain unrecognised when, untreated, it can relentlessly progress to cause severe disfigurement?

Granuloma Inguinale↗
PubMed1988

Granuloma inguinale of cervical lymph nodes simulating tuberculous lymphadenitis: two case reports and review of published reports.

Granuloma inguinale (donovanosis) is commonly thought to be a superficial disease, which spreads by continuity and does not affect the regional lymph nodes. Two patients with the disease affecting lymph nodes in the neck are reported from a series of 108 seen in a continuing study of granuloma inguinale. An immunofluorescent antibody test is described that showed antigenic relatedness between the intracellular organisms in these patients and in patients with typical genital granuloma inguinale. Lymphadenitis associated with granuloma inguinale appears to be a stage in the pathogenesis of the pseudobubo, an uncommon feature of this disease.

Adolescent↗
PubMed1987

Histological aspects of sexually transmitted genital lesions.

Occasional biopsies of genital lesions due to chancroid, secondary syphilis (the condyloma latum) and granuloma inguinale are encountered in routine histopathological practice. These lesions have specific microscopical appearances enabling a confident, or at least a presumptive, diagnosis to be made in most cases, yet the value of biopsy in the diagnosis of these diseases is not generally appreciated. The ulcer of chancroid shows three zones--a narrow superficial zone of degenerate leucocytes and fibrin, a broader middle zone with characteristic vascular changes, and a deep zone in which there is a plasma cell and lymphocyte infiltrate. The condyloma latum shows hyperplasia of the epidermis which is infiltrated with polymorphonuclear leucocytes in addition to the mononuclear infiltration of the dermis. Large numbers of spirochaetes are found in the area of the polymorph exocytosis of the epidermis. The inflammatory infiltrate of granuloma inguinale consists of a neutrophil and plasma cell infiltrate with moderate numbers of large mononuclear cells in which there are one or more vacuoles containing Donovan bodies.

Biopsy↗
PubMed1983

Granuloma inguinale (donovanosis) in South Africa.

Granuloma inguinale is a chronic specific infection of the genitalia of both sexes. It is endemic in many parts of the world, including the Caribbean, the southern USA, India, New Guinea and tropical and subtropical Africa. Apart from a single patient diagnosed clinically, no cases of the disease have previously been reported in the RSA, and some have thought that it did not occur here. A series of 8 cases diagnosed on the Witwatersrand over the past 21 months is presented, suggesting that the disease is endemic in this country and has until now been overlooked by clinicians and pathologists.

Adolescent↗
PubMed1976

Foot pigmentation in Blacks.

Pigmentation of the soles of the feet was studied during postmortem examination of 70 Black patients. Forty-eight (57%) showed some pigmentation (grade II) of the soles of the feet and 4 (6%) showed definite black spots, i.e. focal areas of dense black pigmentation (grade III). A distinction between clinical grade II or grade III lesions could not be made on the basis of microscopic appearance. No true naeyi were seen. Increases of melanin pigmentation and minor degrees of melanocytic proliferation were all that was apparent. Although the development of malignant melanoma may be related to the presence of black spots on the feet of darkly pigmented races, all such spots are certainly not naevi.

Adolescent↗