Biomedical subjects

A L Golin

Publications and source records attributed to A L Golin.

4 recordsLinked to original sources

PubMed1991

Long-term followup of asymptomatic microhematuria.

We present a 10 to 20-year followup assessment of 191 patients with unexplained microhematuria (including persons with insignificant lesions). Genitourinary malignancies did not develop in any of the patients (128 alive and 27 dead) evaluated after the first diagnostic investigation. Patient and physician compliance with followup protocols was poor. We currently recommend renal ultrasound and cystoscopy for the first diagnostic survey, have abandoned routine periodic studies and advise diagnostic studies only for patients in whom symptoms develop.

Aged↗

PubMed1991

Biologic aggressiveness of palpable and nonpalpable prostate cancer: assessment with endosonography.

The biologic aggressiveness of palpable versus nonpalpable prostate cancer was evaluated in 666 patients studied with endosonography over a 24-month period. Biologic aggressiveness was defined by a combined histologic and grade-stage category score. In 314 patients suspected of having prostate cancer 328 biopsies were performed. Carcinoma was detected in 99 patients, by means of both palpation and endosonography (n = 80), endosonography alone (n = 9), and palpation alone (n = 8); two cancers were not detected with either palpation or endosonography. All patients with normal results of digital examination had a combined grade-stage category score lower than 9. Fifty-five of 69 patients (80%) with abnormal results of digital examination and available histologic data had a histologic score of 6 or higher; 38 of these patients (69%) had a combined grade-stage category score of 9 or higher. Although the number of patients is small, these data suggest that nonpalpable cancers are biologically less aggressive than palpable ones and that the advantage of endosonography over palpation in detection of clinically significant cancers is limited.

Adenocarcinoma↗

PubMed1980

Asymptomatic microscopic hematuria.

Asymptomatic microscopic hematuria is a prevalent condition that requires urologic evaluation. Complete assessment must include non-urologic conditions. Of 246 patients reviewed 10 per cent were found to have a urologic neoplasm, while 12 per cent had other significant urologic lesions. However, 51 per cent of the patients had no urologic abnormality discovered and 27 per cent had insignificant urologic findings in which the relationship to microhematuria is questionable. A method of following patients with unexplained microhematuria that may clarify the implications of this disorder is proposed.

Cystoscopy↗

PubMed1977

Cyclophosphamide hemorrhagic cystitis requiring urinary diversion.

Hemorrhagic cystitis secondary to cyclophosphamide is a well recognized and unique urologic complication of this widely used agent. Cessation of the drug and supportive care are usually sufficient for management but refractory cases are difficult to treat and potentially life-threatening. A review of the pathology and treatment of this disorder is presented with specific reference to a patient requiring urinary diversion.

Adult↗