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Biomedical subjects

A L Hartikainen

Publications and source records attributed to A L Hartikainen.

7 recordsLinked to original sources
PubMed1978

Prenatal diagnosis of congenital nephrosis in 23 high-risk families.

The efficacy of maternal serum and amniotic fluid alpha-fetoprotein (AFP) estimation for the prenatal detection of congenital nephrosis was assessed in 23 pregnancies of couples with a previously affected child. At 15 to 18 weeks' gestation, amniotic fluid AFP concentration was elevated in seven of 23 cases, and maternal serum AFP level in five of these. Legal abortion was carried out at 18 to 19 weeks in all those cases where he amniotic fluid AFP concentration was abnormally high, and in all cases the fetus was found to be affected. The diagnosis of intrauterine congenital nephrosis was obvious by electron microscopic examination of the fetal kidney, but not by light microscopy. The child was born without congenital nephrosis in all 16 cases where amniotic fluid AFP level was normal, and in 16 of 18 cases (89%) where maternal serum AFP concentration was normal. Thus, the amniotic fluid AFP assay is more reliable and is recommended whenever congenital nephrosis is suspected on the basis of family history.

Abortion, Legal↗
PubMed1975

The application of spectrophotometry in the investigation of amniotic fluid by amnioscopy. part I. development of the technique.

A method for the incorporation of spectrophotometry to amnioscopy for the colourmetric estimation of amniotic fluid is presented. The spectrum of light reflected from the object under examination was measured using narrow-band interference filters, and a siliceous PIN light diode as the detector. A graphical representation of the spectrum was obtained using an automatic recorder. The preliminary measurements were performed using papers of various colours, clear amniotic fluid and green fluid as well as two patients in late pregnancy who required amnioscopic investigation. Measurements have shown that the apparatus can reliably distinguish different colours from each other and the authors consider that the apparatus may be used in connection with amnioscopy in order to estimate the colour of the amniotic fluid. The possible future use and development of such a technique is discussed.

Amniotic Fluid↗
PubMed1975

The application of spectrophotometry in the investigation of amniotic fluid by amnioscopy. part II. A clinical study.

A spectrophotometric method is presented for use during amnioscopy for the estimation of the colour of amniotic fluid. The application of five different filters was tested; and a ratio of the results obtained using filters with mean wave-lengths of 621 nm and 589 nm was found to be the most reliable parameter for the detection of green coloured amniotic fluid. Preliminary results are so promising that further examinations and a development of the method are indicated. Various improvements to the method are also discussed.

Amniotic Fluid↗