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Biomedical subjects

A L Kukharchuk

Publications and source records attributed to A L Kukharchuk.

11 recordsLinked to original sources
PubMedDate not supplied

[The effect of prostacyclin and its synthetic analog MM-706 on kidney function in corrosive sublimate-induced nephropathy].

The effects of prostacyclin and its stable analogue MM-706 on renal function were examined in rats with sublimate nephropathy. Prostacyclin was shown to attenuate renal dysfunctions by increasing glomerular filtration rate and water and salt reabsorption. MM-706 produced more pronounced protective effects and restored the filtration and reabsorption up to the level observed in control rats.

Animals↗
PubMedDate not supplied

[Effect of a synthetic prostacyclin analog on kidney function and the system of regulation of blood coagulation in experimental acute renal failure].

The influence of a stable analogue of prostacyclin on the renal function and parameters of hemostasis was investigated in experiments on animals with the nephrotic form of acute renal insufficiency. Diuresis, glomerular filtration, water and sodium reabsorption in the presence of diminished intravascular coagulation were recovered after two injections of the compound in a dose of 115 micrograms/kg.

Acute Kidney Injury↗
PubMedDate not supplied

[Effect of destruction of the lateral septal nucleus on renal function].

A conclusion on relationships of the septum with both the antidiuretic and antinatriuretic systems in the regulation of the aqueous-electrolytic balance and renal function has been drawn as a result of the study of the drinking behaviour and renal reaction after the destruction of the lateral septal nucleus (LSN). This conclusion is based on the revealed increase in the urinary excretion of sodium, osmotically active substances, creatinine, titrating acids and ammonia after the LSN destruction. Moreover, an increase of the vasopressin level in the blood plasma, a decrease of aldosterone concentration as well as an activation of the drinking behaviour are noted.

Animals↗
PubMedDate not supplied

[Role of breast feeding in providing the newborn infant with thyroid hormones].

Radioimmunoassay was conducted to study the content of triiodothyronine and thyroxine in the human milk and in the blood serum of mature and premature newborns. It was established that with the growth of the lactation period the content of triiodothyronine and thyroxine rose; it was, respectively, 0.5 +/- 0.12 and 100.3 +/- 8.4 nmol/l in colostrum, 9.2 +/- 0.7 and 271.3 +/- 14.1 nmol/l in transient milk, 11.1 +/- 1.07 and 405.0 +/- 21.4 nmol/l in fully formed milk. Fully formed milk contains three times more triiodothyronine and thyroxine than the blood serum of newborns. The mature newborns have a sufficiently formed thyroid function. The level of thyroid hormones in the blood serum of premature newborns is decreased in proportion to the stage of their prematurity. They receive the deficient hormones through the human milk. The authors recommend that the nutrition of premature newborns receiving mixed and artificial feeding should be supplemented with thyroid hormones.

Breast Feeding↗
PubMedDate not supplied

[Effect of progesterone on the ion-regulating function of the kidneys].

The effect of progesterone on ion-regulating kidney function was studied in experiments on albino male rats under the conditions of spontaneous and water diuresis. Kidney function was evaluated by the level of urination, sodium, potassium and creatinine excretion with regard to the glomerular filtration and tubular reabsorption in water diuresis. Five series experiments were made, including a study of the effect of progesterone on kidney function under the conditions of a low and high sodium diet, adrenalectomy and castration. Progesterone was shown to possess a pronounced natriuretic effect in sodium deficiency in the body and to cause sodium retention in a high sodium diet. Adrenalectomy and castration did not prevent the natriuretic action of progesterone. The elevated excretion of sodium was determined by an increase in its filtration charge. In all the studies sodium excretion changed with a sufficient degree of significance (P less than 0,01 = PI less than 0,05).

Adrenalectomy↗
PubMedDate not supplied

[The participation of the renin-angiotensin-aldosterone system in the pathogenesis of acute kidney failure in endotoxemia].

It was found in acute experiments on white rats that injection of Salmonella typhimurium lipopolysaccharide activates renin-angiotensin-aldosterone system (RAAS) and causes oligohydruria form of acute renal failure (ARF). Enalapril, angiotensin-converting enzyme, being injected simultaneously with endotoxin, increases diuresis, glomerular filtration rate, electrolytes excretion and reabsorption by proximal tubules, decreases proteinuria and blood nitrogen-down to the normal. Thus, RAAS takes part in endotoxemia ARF induction and enalapril has protective effect.

Acute Kidney Injury↗