In 42 patients with cervical sympathicoganglionitis and secondary diencephalic dysfunction, the cerebral circulation was studied by REG in order to elucidate the role of vascular factor in the pathogenesis of diencephalic impairments. The authors established the persistent elevation in the tone of the cerebral vessels in the carotid and vertebral-basilar area and a decrease in the pulse blood filling. The nitroglycerin test indicated the functional nature of the changes. A clear-cut vasculodilating effect following therapy with gangleron administered in the area of the impaired ganglia by graded electrophoresis was observed. It is suggested that vascular factor is involved in the pathogenesis of secondary diencephalic dysfunctions.

Adult↗

PubMed1984

[Pneumoencephalography in multiple sclerosis].

Pneumoencephalography was performed in 35 patients with a significant diagnosis of disseminated sclerosis. Enlargement of the III ventricle was revealed in 21 patients (60%), dropsy of lateral ventricles in 16 (45,6%) and that of the IV ventricle in 13 (37,2%), atrophy of brain stem in 9 (25,4%), block of the subarachnoidal space in 11 patients (31,4%). The most pronounced brain changes were seen in patients with a cerebellar form of disseminated sclerosis and in those having severe motor disturbances, ataxia and tremor. The degree of hydrocephalus did not depend on the disease duration. A possible pathogenetic role of dropsy in disseminated sclerosis is discussed. Hydrocephalus may be considered as an additional clinicoroentgenological feature of disseminated sclerosis.

Adolescent↗

PubMed1983

[Secondary diencephalic dysfunctions in patients with sympathoganglionitis and their pathogenetic treatment].

Novel concepts of both the pathogenesis of secondary trunko-hypothalamic dysfunctions ("repercussive diencephaleses") associated with sympathoganglionites and their pathogenetic therapy are offered. They are based on new fundamental data concerning the physiology of vegetative ganglia, as well as on the findings of the clinical and electroencephalographic examinations, and the results of treatment of 67 patients with cervical sympathoganglionites. The suggested method of pathogenetic therapy consists of pharmacologically-induced blocking of the pathological afferent impulsation from the affected sympathetic ganglion; which is achieved by mild solutions of ganglioblockers administered into the ganglion; which is achieved by mild solutions of ganglioblockers administered into the ganglion by graded electrophoresis. Most of the patients showed a good therapeutic response. Data on the differential use of electrophoresis with either benzohexamethonium or gangleron, depending on the clinical manifestations of the disease, are presented.

Adult↗

PubMed1983

[Diagnosis of familial cases of multiple sclerosis].

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Adult↗

PubMed1976

[Use of glucocorticoid hormones in multiple sclerosis].

A long-term observation over patients with disseminated scleosis who were treated by glucorticoid hormones demonstrated that hormone therapy with short sessions and a standard scheme appeared to be uneffective. The presentation is based on an examination of 25 patients who had undergone a durative course of hormone therapy with an individual scheme of optimal doses equal to middle ones (30-40 mg of prednisolon) and a selection of maintenance doses used for a long time or with short intervals. Such forms of treatment were more effective. During treatment the authors used immunological tests and analysis of electrolytes in the blood, sugar, urea, etc. Hormone therapy is indicated in acute forms of disseminated sclerosis and in a remittent development in the stage of exacerbation in the II and III phases. Along with favourable effects in 3 patients there was a development of hormone dependency and complications.

Acute Disease↗

PubMed1974