Medial canthal tendon reconstruction.
A technique is described for reconstructing a resected medial canthal tendon using medially based orbicularis muscle flaps from both eyelids. A brief review of the literature is discussed.
Adult↗
Biomedical subjects
A L Moss
Publications and source records attributed to A L Moss.
Metastatic tumour in the submandibular salivary gland.
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Adenocarcinoma↗
Inverted papilloma of the nose: an unusual cause of a medial canthal mass.
Inverted papillomata usually rise from the mucosa of the nose and/or sinuses and present with signs and symptoms indistinguishable from those produced by ordinary nasal polyps. This benign neoplasm rarely arises from the nasolacrimal system or presents as an external mass. A case is described that demonstrated both these rare features. It is being reported to draw attention to the existence of this type of tumour and to illustrate its characteristic tendency to local recurrence. A brief review of the literature is given together with a recommended surgical approach.
Adult↗
Altered androgen regulation of differentiated ventral prostate function during aging of the AXC rat.
We have examined testosterone regulation of differentiated androgen responsive ventral prostate function in aging AXC rats as a possible means of identifying age-related changes in prostate gene function. Concerning cellular content of functional macromolecules, we identified three categories of age-related change in ventral prostate: (1) diminutions completely reversible by short-term chronic testosterone treatment, as exemplified by androgen receptor content; (2) diminutions partially reversible by testosterone treatment, as exemplified by prolactin receptor content and L-ornithine-decarboxylase (ODC) activity; and (3) diminutions not reversed by exogenous testosterone treatment, as exemplified by S-adenosyl-L-methionine decarboxylase (AMDC) activity. A fourth category of alteration revealed apparent age-related changes in polyamine homeostasis. The anabolic products of ODC and AMDC activities, putrescine, spermidine and spermine, showed an age-related diminished dependence between the activities of ODC and AMDC and ventral prostate polyamine content. The possibility that these changes reflect age-related alterations in ventral prostate gene activity is under investigation.
Adenosylmethionine Decarboxylase↗
The surgical approach to gynaecomastia.
The main reason patients seek treatment for gynaecomastia is the marked embarrassment this condition causes. The extra-areolar incisions in the surgical treatment may give obvious and hypertrophic scars as embarrassing as the original benign disease. The recommended semi-circular intra-areolar incision to be used to achieve the aims of treatment in this condition--a normal male contour with an imperceptible scar--is described. Four cases are shown comparing the results of surgical treatment using different incisions.
Cicatrix↗
Rhinocerebral mucormycosis.
We report a case of rhinocerebral mucormycosis associated with diabetic ketoacidosis. The features of this rare, fulminating, fungal infection were not appreciated because of ignorance about the condition. The typical features include continued drowsiness in spite of correction of the diabetic ketoacidosis, black ulcer of the palate, septum or turbinate, facial pain, and cellulitis with varying eye and neurological signs. The general aspects of the infection are discussed, emphasizing that the mainstay of treatment is correction of the underlying condition, surgical debridement, and intravenous amphotericin B. Awareness of the condition will enable early diagnosis and adequate treatment to ensure the best chance of survival.
Brain Diseases↗
Hospital outbreak of hepatitis B.
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Cross Infection↗
Aging in the AXC rat: differential effects of chronic testosterone treatment on restoration of diminished prostate L-ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase activities.
L-Ornithine decarboxylase (ODC) activity per 100 mg prostate was diminished 88% and S-adenosyl-L-methionine decarboxylase (AMDC) activity similarly ws diminished 57% in the ventral prostate of aged (26-month-old) as compared to that of young (3.8-month-old) AXC rats. Dorsolateral prostate ODC activity was too low to be reliably quantitated. Dorsolateral prostate AMDC activity per 100 mg prostate was diminished 55% in aged AXC rats. The age-related declines in prostate ODC and AMDC were not attributable to changes in the properties of the enzymes in aged AXC rats compared to young rats. There also was no evidence for an age-related production of inhibitors or inactivators of these prostate enzymes. The sensitivities of prostate ODC and AMDC to orchiectomy were comparable in young and aged AXC rats. Treatment of aged AXC rats with exogenous testosterone did not enhance ventral prostate AMDC activity per 100 micrograms DNA, but it did elevate dorsolateral prostate AMDC activity per 100 micrograms DNA to levels indistinguishable from those characteristic of untreated young AXC rats and caused a 303% increase in ventral prostate ODC activity per 100 micrograms DNA. However, ODC activity per 100 micrograms DNA in the ventral prostate of testosterone-treated aged rats was only 49% of that characteristic of untreated young AXC rats. We have identified three categories of age-related changes in prostatic enzyme activity: 1) decline fully reversible by exogenous testosterone, 2) decline partially reversible by exogenous testosterone, and 3) decline not reversible by exogenous testosterone. These alterations may reflect age-related changes in androgen-regulated prostate gene function.
Adenosylmethionine Decarboxylase↗
Aging in the AXC rat: equivalence of the rates of inactivation of l-ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase in prostate of young and aged rats.
The incorporation of leucine into proteins of ventral and dorsolateral prostates of young (3- to 4-month-old) and aged (24- to 26-month-old) AXC rats was examined in vivo. We established that a single injection of cycloheximide (500 micrograms/100 g BW) maintained 91% (ventral) or 86% (dorsolateral) inhibition of protein synthesis in prostates of young AXC rats and 90% (ventral) or 88% (dorsolateral) inhibition of protein synthesis in prostates of aged AXC rats through at least 120 min post injection. During cycloheximide-maintained inhibition of protein synthesis, the rate of inactivation of ventral prostate L-ornithine decarboxylase (ODC) or S-adenosyl-L-methionine decarboxylase (AMDC) activity and dorsolateral prostate AMDC activity was comparable in the prostates of young and aged AXC rats. The absence of an age-related change in the rate of inactivation of prostatic ODC or AMDC activity provides additional evidence that the age-related decrease in prostatic ODC and AMDC activities reported in the companion article may reflect altered androgen regulation of prostatic gene activity.
Adenosylmethionine Decarboxylase↗
Thermoluminescent properties of topaz.
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Aluminum Silicates↗
Microvascular second toe to finger transfer: a statistical analysis of 55 transfers.
A series of 55 second toe to long finger transfers in 42 patients are reviewed. The mean age is 17 years. The mean follow-up is more than 4 years. Two-point discrimination averages 8 mm. The sensibility is influenced by age, amputation score, ischaemic time, number of arteries, level of amputation, mobility, compensation injury and sensory re-education. The mean mobility is 33 degrees of flexion with a mean extension lack of 34.5 degrees. The mobility is influenced by dominance, amputation score, ischaemic time, number of arteries, level of amputation and compensation injury. There are four failures (7.2%). This rate of complication is influenced by tobacco, age, number of arteries and level of vascular anastomosis.
Adolescent↗
Desmoplastic melanoma: a clinico-pathological review.
Desmoplastic Melanoma (DM) represents a rare histological variant of melanoma. It has been described in isolated case reports as a cutaneous tumour with a high incidence of local recurrence and nodal metastases, requiring early aggressive surgery. However, overall clinical experience of the tumour is limited. 13 patients with DMM seen over a 20 year period were reviewed. The mean age at presentation was 67 years (range 34-87), and 2/3 of the lesions were in the head and neck. Tumour thickness averaged 5.78 mm (Breslow). 7 patients developed recurrence, 4 as regional nodes, and 3 as skin nodules. Four of these patients developed disseminated disease, of whom 3 died. The mean time to first recurrence was 26 months and mean follow-up time in the review was 40 months (range 3-141 months).
Adult↗