PubMed Health⌕ Search

Biomedical subjects

A L Norins

Publications and source records attributed to A L Norins.

At least 19 recordsLinked to original sources
PubMed1989

Juvenile dermatomyositis.

Juvenile dermatomyositis is a chronic disease of childhood that is manifested by severe symmetrical progressive muscle weakness, a characteristic heliotrope colored skin rash which involves the face, and by elevated serum enzymes related to muscle damage.

Child↗
PubMed1989

Skin cancer in patients with chronic radiation dermatitis.

The cases of 76 patients with chronic radiation dermatitis resulting from low-dose ionizing radiation for benign disease were reviewed retrospectively for risk factors leading to the development of neoplasia. The patients were studied with respect to original hair color, eye color, sun reactive skin type, benign disease treated, area treated, age at treatment, and age at development of first skin cancer. Analysis of data showed 37% of patients had sun-reactive skin type I, 27% had type II, and 36% had type III. Types IV through VI were not represented. There appeared to be an overrepresentation of types I and II. Increased melanin pigmentation may therefore be either directly or indirectly protective against the development of skin cancers in patients who have received low-dose superficial ionizing radiation for benign disease. The sun-reactive skin type of patients with chronic radiation dermatitis may be used as a predictor of skin cancer risk when the total dose of ionizing radiation is not known.

Basal Cell Carcinoma↗
PubMed1987

Locally invasive cellular blue nevus of the scalp.

The cellular blue nevus, although benign by accepted pathological criteria, may behave in an aggressive fashion. Distant metastases may occur as malignant melanoma. This case illustrates the potential malignant degeneration and spread of a "benign" neoplasm. A broader definition of malignancy to include the clinical behavior of cellular blue nevus may be in order.

Adolescent↗
PubMed1986

Chemotherapy-induced acral erythema in patients receiving bone marrow transplantation.

Chemotherapy-induced acral erythema is an uncommon and distinctive syndrome of intense macular erythema of the palms and fingers seen in patients treated with high-dose chemotherapy. It is painful, may form bullae, and heals uneventfully with desquamation. The incidence (35%) of this complication in patients receiving bone marrow transplantation at our institution is quite high and probably reflects the exceptional doses of chemotherapy and concomitant total body irradiation these patients receive. Biopsy specimens showed vacuolar change, spongiosis, necrotic keratinocytes, and epidermal atypia. These findings probably result from direct toxic effect and mimic those of acute graft-vs-host disease. Awareness of chemotherapy-induced acral erythema is important to avoid its misdiagnosis as a cutaneous sign of acute graft-vs-host disease. This distinction can usually be made on clinical grounds. If necessary, serial skin biopsy specimens are helpful.

Adolescent↗
PubMed1985

Cutaneous inoculation tuberculosis secondary to 'jailhouse tattooing'.

Cutaneous inoculation tuberculosis is rare in the United States today. When seen, it usually occurs in individuals whose occupations or environments place them at increased risk for exposure to Mycobacterium tuberculosis. The reaction of the skin to M tuberculosis infection is polymorphous and depends upon the interplay of bacterial virulence and host immunity. Thus, both a high index of suspicion and positive cultures are required to make the diagnosis. Herein, we report a case of cutaneous inoculation tuberculosis occurring in a tattoo.

Adult↗
PubMed1984

Halo scalp ring: a form of localized scalp injury associated with caput succedaneum.

Caput succedaneum is a common birth injury attributed to cervical, uterine, or vaginal pressure on the fetal presenting part. It usually consists of diffuse soft tissue swelling and bruising, which resolve in a few days without sequelae. We have seen two patients who had an unusual alopecic "halo" ring on the scalp associated with a caput succedaneum.

Alopecia↗
PubMed1979

Intestinal pseudo-obstruction in mucocutaneous lymph-node syndrome.

Mucocutaneous lymph-node syndrome (MCLS) is an acute exanthem with specific clinical features, sometimes complicated by involvement of internal organs. Two patients with MCLS had clinical and radiographic evidence of mechanical small-bowel obstruction, probably on the basis of focal vascular insufficiency, as anatomic obstruction was not documented in either instance. The cases indicate that intestinal involvement in patients with MCLS can simulate intestinal obstruction, and conservative management of such patients is appropriate.

Child, Preschool↗
PubMed1978

A multicentered study of lysine therapy in Herpes simplex infection.

Lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312-1,200 mg of lysine daily in single or multiple doses. The clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from herpes simplex infection and suppressing recurrence. Tissue culture studies have demonstrated an enhancing effect on viral replication when the amino acid ratio of arginine to lysine favors arginine. The opposite, preponderance of lysine to arginine, suppresses viral replication and inhibits cytopathogenicity of herpes simplex virus. The codons characterizing herpes simplex DNA apparently specify production of viral capsids at the expense of host cell histones.

Adolescent↗