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Biomedical subjects

A L Peters

Publications and source records attributed to A L Peters.

45 records · Page 3Linked to original sources

Ocular cysticercosis. A report of 13 cases.

Ocular cysticercosis does not usually present with signs of systemic involvement. Stool examination and eosinophil count are invariably negative, but computed tomography and agglutination tests are more commonly positive. This condition is more common in the vitreous cavity where it may cause diagnostic problems. Removal of the cyst is a standardised procedure, but the prognosis is poor because of severe ocular reaction to the cysts. Prevention of cysticercus infection is very important.

Adult↗

Miconazole and ketoconazole as a satisfactory first-line treatment for keratomycosis.

In 20 patients (11 males and nine females, 3 to 65 years old) with fungal keratitis, Fusarium was identified in eight cases, Aspergillus in four, Drechslera in three, and Curvularia, Candida, and Nocardia in one each. In two cases the organism was not identified. Treatment with topical and subconjunctival miconazole along with ketoconazole resulted in healing in 13 cases. Modification of this regimen produced healing in three additional cases. Four cases progressed to blindness despite therapy.

Adolescent↗

Purine degradation in Pseudomonas aeruginosa and Pseudomonas testosteroni.

1. Adenine, hypoxanthine, xanthine and guanine are broken down in Pseudomonas aeruginosa and Pseudomonas testosteroni to allantoin by the concerted action of the enzymes adenine deaminase, guanine deaminase, NAD+-dependent xanthine dehydrogenase and uricase. 2. Uric acid is broken down by an unstable, membrane-bound uricase with an unusually low pH optimum. 3. In both strains adenine inhibits growth and xanthine dehydrogenase. A second type of inhibition is manifest only in Ps. testosteroni and concerns the regulation of the biosynthesis of amino acids of the aspartate family. Enzymic studies showed that in this strain aspartate kinase is inhibited by AMP.

Adenine↗

Effects of various enteral feeding products on postprandial blood glucose response in patients with type I diabetes.

These studies were performed to evaluate the postprandial blood glucose responses to a variety of differently formulated enteral feeding products in patients with type I diabetes. Eleven subjects with type I diabetes were evaluated in three studies, all using a Biostator (artificial endocrine pancreas) that delivered a small, basal amount of insulin and measured blood glucose levels. Subjects consumed 20 mL of the assigned formula every 15 minutes for the 240 minutes of the study. Study 1 evaluated the response to each of five products: Glucerna, Enrich, Ensure HN, Pulmocare, and Compleat Modified. When the postprandial blood glucose response to Glucerna was greater than when its research formulation (EN-8715) had been tested in 1988, studies 2 and 3 were undertaken to assess why this discrepancy occurred. Study 2 compared stored EN-8715 to Glucerna and study 3 compared frozen and thawed vs nonfrozen EN-8715, because of a concern that the original product had been frozen during shipping. In study 1 the glucose response (assessed as area under the glucose curve) correlated with the grams of carbohydrate present in the enteral feeding formula (r = .58, p = .002). The presence or absence of fiber, in the form of soy polysaccharide, did not affect the glucose response. Glucerna produced a significantly lower blood glucose response than did Enrich, Ensure HN, or Compleat Modified, although this response was greater than the response to EN-8715 in 1988. However, in study 2 no differences were found between stored EN-8715 and Glucerna and in study 3, freezing and thawing was not found to significantly alter the glucose response.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗