Leukocyte interferon production, RNA synthesis, and PHA response in patients with infectious mononucleosis.
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Adolescent↗
Biomedical subjects
A L Pidot
Publications and source records attributed to A L Pidot.
Human leukocyte interferon: the variation in normals and correlation with PHA transformation. 1.
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Adult↗
Dye uptake assay: an efficient and sensitive method for human interferon titration.
Currently, human interferon (IF) assays are generally performed by plaque reduction or visual cytopathic effect methods. Both are time-consuming, subjective in interpretation, and, in the case of the latter, relatively insensitive. An adaption of the dye uptake method for human IF titration which uses foreskin-derived fibroblasts and vesicular stomatitis virus is described. This assay is reproducible and sensitive (1 unit = 3 international units). By direct comparison, however, it is somewhat less sensitive than the plaque reduction assay (1 unit = 1.1 international units). This assay is especially recommended for use in needed clinical investigations of human IF because of its technical simplicity, allowing efficient handling of large numbers of specimens.
Cell Count↗