Double blind study using amantadine hydrochloride in the therapy of Parkinson's disease.
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Biomedical subjects
Publications and source records attributed to A L Sahs.
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The overall management results after aneurysmal rupture were studied in 158 patients admitted to the hospital on day 0--3 and 175 patients admitted on day 4--7 following subarachnoid hemorrhage. In this series surgery was planned no sooner than 12 days following the ictus. Despite effective medical and surgical therapy overall results were disappointing: 3 months following the initial hemorrhage only 43% of patients in the 0--3 day group and 53% of patients in the 4--7 day group were capable of independent functional living. Patients admitted on days 4--7 also had a lower mortality rate, re-bled less frequently, and had lower postoperative mortality and morbidity than those admitted on days 0--3. For reasons not well defined, time of admission following aneurysmal SAH has an important influence on outcome. Accordingly, in evaluating outcome for patients with ruptured aneurysms treated with different therapeutic modalities, time of admission must be carefully controlled.
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Between January 1970 and January 1978, one hundred eighty-two patients were admitted to the University of Iowa Hospitals for treatment of subarachnoid hemorrhages secondary to a ruptured aneurysm. The correct diagnosis had been delayed in 41 patients, with most treated from four to seven days before the correct diagnosis was established. Generally, these patients were initially less acutely ill than those patients whose conditions were promptly diagnosed. The most common misdiagnoses were systemic infectious illness, migraine headache, and hypertensive encephalopathy. Rebleeding occurred in three patients before the correct diagnosis was made. Atypical symptoms, problems in diagnosis, and the need for prompt therapy are reviewed.