PubMed Health⌕ Search

Biomedical subjects

A L Schocket

Publications and source records attributed to A L Schocket.

9 recordsLinked to original sources
PubMed1979

Lymphocytotoxic antibodies in systemic lupus erythematosus and clinically related diseases.

Sera from patients with systemic lupus erythematosus (SLE) and clinically related diseases were examined for cold-reactive lymphocytotoxic antibodies (LCA). The incidence of LCA was significantly increased in SLE (93%), discoid lupus (50%), and "lupus-like" syndromes associated with congenital complement deficiencies (63%) as compared to normal controls (3%) and patients with drug-induced lupus (11%), mixed connective tissue disease (MCTD) (17%), and necrotizing vasculitis (19%). The diagnostic and pathogenetic implications of these differences are discussed.

Antilymphocyte Serum↗
PubMed1979

Exercise-induced anaphylactic reaction to shellfish.

The syndrome of immediate type I food hypersensitivity, mediated by tissue-bound IgE antibody and mast cell histamine release, is well recorded in the medical literature. This case study represents a previously undescribed late food hypersensitivity, induced only by strenuous exercise. Identification of this new syndrome illustrates classical epidemiologic analysis, improves medical advice for the allergic and athletically inclined, and raises new questions in the areas of allergy and immunology.

Adult↗
PubMed1979

The effects of H1 and H2 antihistamines on histamine inhalation challenges in asthmatic patients.

This study was designed to examine the effect of an H1 antihistamine, chlorpheniramine, an H2 antihistamine, cimetidine, and the combination of chlorpheniramine and cimetidine on histamine-induced bronchoconstriction in a double-blind, randomized protocol on 11 patients with asthma. Each patient underwent a histamine inhalation challenge on 5 separate days. After a control day, histamine inhalation challenges were performed 2 h after the administration of a single oral dose of 8 mg of chlorpheniramine, 300 mg of cimetidine, the combination of chlorpheniramine and cimetidine, or placebo. Baseline pulmonary function measurements were not significantly altered by the 4 treatments. Body plethysmography data and measurements from the forced vital capacity maneuver were obtained before and after the histamine inhalation challenges. The provocation dose of histamine that produced a 20% decrease in forced expiratory volume in one second, a 35% decrease in mean forced expiratory flow during the middle half of the forced vital capacity, and a 50% decrease in specific airway conductance was significantly increased after administration of chlorpheniramine (p less than 0.002) and decreased after administration of cimetidine (p less than 0.02), where as no significant effect was noted after the combination of chlorpheniramine and cimetidine. The results suggest the presence of both H1 and H2 receptors in the airways of asthmatic patients.

Adolescent↗
PubMed1979

Lymphocytes in multiple sclerosis: correlation with CSF immunoglobulins and cold-reactive lymphocytotoxic antibodies.

Lymphocyte profiles were studied in patients with multiple sclerosis (MS) and normal controls. Apart from cold-reactive lymphocytotoxic antibodies (LCA), which were elevated in MS patients, there was no difference between MS patients and normal controls in terms of lymphocyte subpopulations, serum immunoglobulins, or responses to mitogens. There was no correlation between LCA and any of the immunologic characteristics measured. However, there was a correlation between immunoglobulin-bearing cells in the peripheral blood of MS patients and cerebrospinal fluid (CSF) levels of immunoglobulin and CSF viral antibodies. These results suggest that cold-reactive lymphocytotoxic antibodies do not affect lymphocyte function in patients with MS, that antigens stimulating "local" central nervous system (CNS) antibody production may be located outside the CNS and that locally produced CNS antibody may be made by immunoglobulin-bearing cells that migrate to the CSF from the periphery after exposure to antigen.

Adolescent↗
PubMed1978

Lymphocytotoxic antibodies in family members of patients with multiple sclerosis.

Cold-reactive lymphocytotoxic antibodies were found in sera from 14 of 21 (67%) patients with multiple sclerosis. A significantly (p less than 0.01) greater frequency of these antibodies was also demonstrated in patients' household members (12 of 18 [67%]) compared to siblings living elsewhere (3 of 14 [21%]) or normal controls (1 of 13 [8%]). No difference in antibody frequency was found between consanguineous and non-consanguineous family members. These findings suggest that the increase frequency of lymphocytotoxic antibodies in these multiple-sclerosis patients and their family members is an indicator of the presence of a transmissible agent, probably a virus, in many patients with multiple sclerosis.

Adult↗
PubMed1978

Immune complex vasculitis as a cause of ascites and pleural effusions in systemic lupus erythematosus.

A patient is described with systemic lupus erythematosus and large painless ascites and pleural effusions. Pleural and peritoneal fluid complement levels were depressed, and DNA binding was elevated in the presence of normal serum values. Immunoglobulin and complement deposits were demonstrated in vessels of the pleura, peritoneum, and skin, along with histologic evidence of vasculitis. The relation of the ascites and pleural effusions to the presence of widespread vasculitis and local immune complex formation is discussed. These complications responded poorly to corticosteroid therapy but slowly resolved following the addition of an immunosuppressive agent.

Adult↗