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Biomedical subjects

A L Weaver

Publications and source records attributed to A L Weaver.

At least 127 records · Page 7Linked to original sources
PubMed1991

Serum selenium concentrations in rheumatoid arthritis.

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

Adult↗
PubMed1991

Simple bunionectomy with medial capsulorrhaphy.

Bunionectomy with medial capsulorrhaphy was performed on 54 feet (37 patients) and follow-up was obtained on 49 feet (33 patients) at a mean of 4.8 years postoperatively. Results were excellent in 17 feet, good in 16, fair in 7, and poor in 9. Mean motion of the first metatarsophalangeal joint was 81 degrees. The primary reason for failure was recurrent deformity. Patients were dissatisfied with the results in 41% of the feet. Mean intermetatarsal 1-2 angle increased 1.7 degrees and mean metatarsophalangeal-1 angle increased 4.8 degrees. The operation was significantly more successful in patients who underwent it for painful medial eminence. Bunionectomy with medial capsulorrhaphy is recommended for elderly patients with symptoms primarily due to prominent medial eminence, and its application for the young patient with significant hallux valgus deformity is limited.

Adolescent↗
PubMed1990

Prospective two-year followup of recombinant interferon-gamma in rheumatoid arthritis.

Seventy patients with rheumatoid arthritis (RA) completing a 12-week multicenter double blind trial comparing recombinant human interferon-gamma (r-IFN-gamma) with placebo were enrolled in a longterm prospective protocol evaluating r-IFN-gamma in RA. Forty (57%) patients after 1 year and 26 (37%) patients after 2 years continued the drug with sustained clinical benefit. Over 2 years, r-IFN-gamma was discontinued in 44 patients (lack of efficacy--25, withdrawn consent--7, noncompliant--4, suspected adverse drug reactions--2, concurrent illness--6). Two years of treatment with r-IFN-gamma were well tolerated with sustained clinical benefit in some patients with few significant adverse drug reactions.

Arthritis, Rheumatoid↗
PubMed1989

Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis.

One hundred five patients were enrolled in a 12-week, randomized, prospective, double-blind, placebo-controlled trial of recombinant human gamma-interferon (rHu gamma-IFN) for the treatment of rheumatoid arthritis. Fifty-four patients received rHu gamma-IFN and 51 received placebo. Forty-two patients in each group completed the 12-week trial. Some clinical improvement occurred in both groups of patients. Although the improvement with rHu gamma-IFN was greater than that with placebo, the differences were generally not statistically significant.

Adult↗
PubMed1989

Endoscopic evaluation of rioprostil in the management of non-steroidal anti-inflammatory drug-induced gastritis: an interim analysis.

The effects of the synthetic prostaglandin E1 analogue, rioprostil, on non-steroidal anti-inflammatory drug-induced (NSAID) gastritis are investigated. The study is of randomized, double-blind design. Patients are included who had classical or definite rheumatoid arthritis or osteoarthritis, had been taking a stable dose of NSAID or aspirin for at least one month and had endoscopically proven gastric lesion. Endoscopy is performed prior to, and at 4, 8 and 12 weeks of the treatment period. Patients receive either rioprostil, 300 micrograms or 100 micrograms q.d.s., or placebo q.d.s. The results of the endoscopies show greater healing of the mucosa in patients taking rioprostil compared with those taking placebo. It is therefore concluded that rioprostil is an effective compound for the management of patients with NSAID-induced gastritis.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

Anterior shoulder reconstruction: prognostic variables.

To evaluate factors that have prognostic relevance to the outcome of anterior shoulder stabilization procedures, a retrospective review of 282 serial anterior repairs was carried out. All patients were contacted by questionnaire to provide updated outcome information. Twenty-nine patients were lost to follow-up, leaving 253 shoulders in the series. Surgical outcome was based on the Rowe scores derived from the responses to the follow-up survey. At a mean follow-up of 8.7 years, 5 factors were found to have a negative influence on the result of surgery, on the basis of multivariate analysis. These were the presence of a workers' compensation issue, a voluntary instability pattern, a prior instability surgery, shorter periods of postoperative immobilization, and the age of the patient. Factors that were found to have no statistically significant relationship to the result were the sex of the patient, the presence of a Hill-Sachs lesion, the type of instability, the presence of a labral tear, and the experience of the surgeon. Knowledge of these factors can help guide surgical decision making.

Adolescent↗