Evaluation of organ injuries in Paraquat intoxication.
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Biomedical subjects
Publications and source records attributed to A Láng.
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Fifty-six cases of paraquat poisoning were examined during the 8 years 1977-1984. The ratio of cases of accidental to intentional ingestion of the poison was 1:1; 23.2% of the total (13/56) survived several months or years. In 1983, 11 subjects accidentally drank 10-30 ml of gramoxone; eight of 11 died in 2 weeks. Toxicological investigations demonstrated rapid elimination of poison from the blood, as well as prolonged fixation of paraquat in the lung, kidney, liver, and spleen tissues. Histological examinations showed multiorgan failure from renal tubular necrosis and pulmonary hemorrhage with alveolar epithelial injury. Pulmonary proliferative changes were present in only two cases who survived 7 and 10 days and in which artificial ventilation was utilized.
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Investigating the skeletons of 25 suicide victims the authors have found that the toxic materials taken can rather comfortably and safely be detected in the compactbony substance. Especially important that the poisonous drug residues can remain in the bones for a long time, even for years after death.
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