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Biomedical subjects

A López Muñiz

Publications and source records attributed to A López Muñiz.

16 recordsLinked to original sources
PubMed2001

[Adult congenital anomalies of the coronary arteries described over 31 years of angiographic studies in the Asturias Principality: main angiographic and clinical characteristics].

OBJECTIVE: The aim of this study was to determine the incidence of adult congenital anomalies of the coronary arteries over 31 years of angiographic studies, describing their angiographic and clinical characteristics. The results have been compared with the main series published. METHODS: The diagnostic angiographic reports done in the Principado de Asturias from 1968 to 1999 are reviewed. In those in which a congenital anomaly was diagnosed, the clinical report and the angiography were studied. The initial course of the anomaly was defined following angiographic criteria. RESULTS: Thirteen thousand five hundred reports were reviewed describing 75 patients with 75 anomalies (0.5%) including: anomalous origin of the left circumflex coronary artery (n = 24), coronary artery fistulae (n = 21), both coronary arteries arising from the left coronary sinus (n = 15), single coronary arteries (n = 6), both coronary arteries arising from the right coronary sinus (n = 2), separated origin of anterior descending and left circumflex coronary arteries (n = 3), anterior descending artery arising from the right coronary sinus (n = 2), and others (n = 1). Angiographic studies were done because of: angina (59%), dysnea (25%), atypical chest pain (7%), syncope (3%), dizziness (3%) and palpitations (3%). The initial course was retroaortic in all the circumflex arteries, interarterial in the right coronaries, anterior in the anterior descending arteries and retroaortic, septal and combined, in the left coronaries. CONCLUSIONS: Adult congenital anomalies of the coronary arteries are not very common and are usually casual findings of diagnostic angiographic studies. Left circumflex coronary artery anomalies are the most frequently diagnosed.

Adult↗
PubMed1998

[Familial study of patients with hereditary hemorrhagic telangiectasia].

Rendu-Osler-Weber's disease or Hereditary Hemorrhagic Telangiectasia (HTT) is an autosomal dominant hereditary clinical entity characterized by the presence of telangiectasias on skin, mucous membranes and internal organs. The incidence of hepatic, pulmonary or cerebral complications justifies an early diagnostic. A familiar study of patients previously diagnosed of HTT in our hospital was made, establishing a protocol for the identification of asymptomatic or pauci-symptomatic cases. Fourteen patients were studied: 6 with a previous diagnostic, and 8 familiar contacts. Penetrance was of 85%. Epistaxis (80%) and telangiectasias on skin were the most frequent clinical findings. The visceral lesions found were gastrointestinal (28%), hepatic (15%), urological (15%) and pulmonary (7%). All patients were included in an hepatitis B virus vaccination program. It was also made a morphological study with Werhoeff's staining of the elastic layer, that allowed to distinguish both arterial and venous alterations.

Adult↗
PubMed1994

[Oncoprotein p53].

Explore the source record for details and available documents.

Gene Expression Regulation, Neoplastic↗
PubMed1989

[The small intestine in the presence of endotoxins in the blood. Effects of splenectomy].

We have studied the small intestine by morphologic and histochemical methods of mice treated with Serratia marcescens endotoxin (LD50); the half of the control and endotoxemic animals were splenectomized. We have not observed changes in the only splenectomized animals. We have found important alterations during the endotoxemia in the structure of small intestine, specially in the cells of the mucous membrane, as the cytoplasm and the nucleus. There are an increase of hemorrhagic phenomenons and of mucus, hemodynamic disturbances and loss of continuity of the intestinal wall. These changes are more notable in the endotoxemic and splenectomized animals than in the only endotoxemic animals. These results have be ratified by cytometric and statistic studies. The importance of the intestine in the endotoxemia and the function of the spleen are discussed.

Animals↗