COUPLING OF CYCLIC CHEMOTHERAPEUTIC COMPOUNDS TO IMMUNE GAMMA-GLOBULINS.
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Biomedical subjects
Publications and source records attributed to A LEWIS.
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During the period 1957-1962, the Committee on Maternal and Child Care of the California Medical Association and the State Department of Public Health studied 551 deaths of women who died during or within 90 days of termination of pregnancy. Of the 356 deaths from obstetric causes, 109 were attributed to abortion. Of the 195 deaths from non-obstetric causes, about one-half were considered by review committees to have been related to pregnancy.
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The California State Department of Public Health has made an analysis of descriptive items from 369,304 birth and death certificates for 1959 and 252,400 certificates for 1949 in order to identify demographic characteristics associated with perinatal mortality and survival. If the time span of risk of perinatal death is defined as 20 weeks gestation through 27 days after birth, 97 of 100 infants born in California during 1949 and 1959 were born alive and survived the first month of life. Fetal and neonatal death rates decreased over the decade to new lows. Since most of the improvement was among infants that weighed 2,501 grams or more at birth, a greater proportion of all perinatal deaths occurred among premature infants in 1959 than 1949. Survival chances for premature infants remained 75 out of 100 total births. Trends shown by a comparison of the years 1949 and 1959 include a 47 per cent increase in number of births, proportionately more births to mothers under 20 and to women with four or more previous live births, more Negro births and fewer births outside a hospital. An important gain in perinatal survival was found among babies of multiparous mothers. All types of hospitals had lower fetal and neonatal mortality, but county hospitals showed the greatest improvement. Less populated areas lowered their perinatal death rates more than major metropolitan areas when average rates for 1945-1949 and 1955-1959 were compared.
If the time span of risk of perinatal death is defined as the period from 20 weeks gestation through 27 days after birth, 97 out of 100 infants born in California during 1959 were born alive and survived the first month of life. The California State Department of Public Health made an analysis of descriptive items from 358,388 birth and 10,916 death certificates to identify demographic characteristics associated with perinatal mortality and survival. Maturity of the infant was the single most important factor; two-thirds of all perinatal mortality was among infants weighing 2,500 grams or less. An infant premature by any two of three criteria (birth weight, birth length or gestation) had less chance of surviving than an infant premature by only one; infants premature by all three measures had the poorest prospect of being born alive and surviving one month. Nonwhite premature infants fared better than white; Oriental infants of all weights showed remarkable survival capacity. Female infants of all races had a survival advantage over males up to weights of 4,501 grams or more.Certain "high-risk" groups of infants were identified: Infants premature by more than one criterion, Negro infants, infants who were one of a set of twins or triplets, infants born to older mothers or to very young multiparae, infants of mothers with four or more previous live births, those born by cesarean section, infants of families in low income occupations, infants of military personnel, infants born in county or federal hospitals, those born outside a hospital, those born to mothers who had no prenatal care and those born in northern, mountain counties.
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In a study of 1,609 single live births occurring in San Francisco County, the information on the birth certificate was compared with that on the hospital record to determine completeness and accuracy of the items reported on the certificate. Items such as color or race of mother, age of mother, birth weight and birth length of child were well recorded on the certificate and agreed with information found in the hospital record. Medical conditions were grossly underreported on the birth certificate. Conditions relating to the mother were more frequently recorded than those relating to the infant, but the birth certificates recorded less than one-fifth of all medical conditions of both mother and infant that were entered in the hospital records. Methods suggested for improving the quality of maternal and newborn morbidity information include revision of the medical section of the present certificates of live birth and fetal death and use of a precoded hospital record.
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