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Biomedical subjects

A Labbé

Publications and source records attributed to A Labbé.

At least 19 recordsLinked to original sources
PubMed1996

[Treatment of acute bronchiolitis in infants. Role of bronchodilators and steroids].

The management of infant bronchiolitis with bronchodilators and steroids is controversial. A literature review on this topic allows to determine the influence of these medications on the first episode of viral bronchiolitis. The effect of alpha and beta adrenergic drugs is undoubtful but it is not possible to anticipate a positive or negative response based on the age of the child nor on a family history of atopic disease. Systemic steroid therapy has no immediate effect but inhaled steroids may be tried during the recovery period to reduce short term morbidity.

Acute Disease↗
PubMed1992

Comparative study of the binding of prolactin and growth hormone by rabbit and human lung cell membrane fractions.

The specific binding capacities for human prolactin (hPRL) and human growth hormone (hGH) were examined in human lung membrane preparations at different developmental stages. A parallel study was carried out on rabbit lung preparations to compare binding parameters. Lung tissues were obtained from 15 fetuses of 16-38 weeks after spontaneous or therapeutic abortion and from 7 adults (lobar resection surgery). A histological study was systematically performed with a radial alveolar count in the fetuses with suspected hypoplasia. Binding analysis was performed on both intact membrane preparations and MgCl2-treated membranes, using [125I]hGH and [125I]hPRL as tracers. In the rabbit lung, specific [125I]hGH binding was found. Scatchard analysis revealed a single class of binding sites (affinity constant: 2.6 +/- 0.8 x 10(9) l/nmol and number of binding sites: 9.5 +/- 4.3 fmol/mg protein for adult rabbit; 1.85 +/- 0.5 x 10(9) l/nmol and 27.6 +/- 3.0 fmol/mg protein for 25-day-old rabbit fetuses, respectively). In contrast, [125I]hPRL did not specifically bind to lung membrane preparations. In the human lung, no consistent specific binding sites for [125I]hPRL or [125I]hGH (less than 0.5%/mg protein) were detected in adults and in 11 of the 15 fetuses. In 4 fetuses, little specific binding was observed (0.59-1.9%/mg protein) for [125I]hGH and (1.5%/mg protein) for [125I]hPRL. There was no correlation with histological lung structure. Our findings confirm the presence of specific binding sites for GH in the adult rabbit lung and demonstrate such binding in the fetal rabbit lung. In contrast, our results showed no significant binding for PRL and GH in the human lung, suggesting that these hormones do not play a direct physiological role in human lung growth and maturation.

Animals↗
PubMed1992

[Follicular bronchiolitis: a pediatric case report].

A case of bronchiolitis of insidious evolution appearing in an unweened infant aged six months is reported. Initially an acute episode of bronchial obstruction was followed by respiratory failure with failure to thrive. The total inefficacy of conventional treatment (corticosteroids, nebulised and oral bronchodilators) led to assisted ventilation for three weeks, four months after the onset of symptoms. All investigations aimed at achieving a diagnosis were negative and this led to an open lung biopsy. This showed characteristic lesions of bronchiolitis and follicular bronchitis without other parenchymatous disease. With continuous antibiotics and physiotherapy the respiratory status improved, both clinically and radiologically. Amongst the explanations of the pathophysiology of follicular bronchitis they also discussed the existence of heterozygous delta F 508 in their observation to explain the chronicity of the problems. They stress the need to look for a mutation of delta F 508 in infants who present with unexplained obstructive bronchial pathology.

Anti-Bacterial Agents↗
PubMed1991

[Determination of nasal transepithelial potential difference (DDPTE) in cystic fibrosis. Analysis of a simplified measurement technique].

Measurements of nasal transepithelial potential differences (TEPD) were performed in 77 patients in order to assess a routine simplified method of recording. TEPD assays were performed in 34 patients with cystic fibrosis aged 1 month to 25 years, in 22 children with another chronic respiratory illness and in 21 subjects without any bronchopulmonary impairment. In the cystic fibrosis group TEPD values (mean +/- SD) were significantly higher (-49.077 +/- 9.38 mV) than in patients with chronic respiratory illnesses (-20.590 +/- 5.011 mV) or in subjects without bronchopulmonary impairment (-19.857 +/- 5.033 mV) (p less than 0.0001). Measurements could not be performed in 10 patients due to major nasal inflammation. The excellent specificity (100%) and sensitivity (93%) of the method confirm its diagnostic value. It may be used from the neonatal period and may represent an alternative to the sweat test, especially in dubious cases.

Child↗
PubMed1991

[Morbidity and psychomotor development at 2 years of age in children born in Puy-de-Dome in 1983. Study of children groups defined by perinatal risk].

All infants born in the Puy-de-Dôme area in 1983 and referred to a neonatal care unit were studied prospectively. Children were seen at their homes at 9 months and at 2 years of age and results were compared with those found in controls. High risk groups were defined on the basis of neonatal variables including prematurity, neurologic anomalies, respiratory distress, assisted ventilation, and growth retardation. At birth, prematurity was associated with an increased risk of respiratory distress and infections were more common in small-for-dates infants. Evaluations at 9 months and at 2 years of age showed increased prevalences of growth retardation and strabismus in the high-risk infants, and neurodevelopmental tests disclosed lower performances in these children. Conversely, infectious diseases and readmissions between birth and two years of age were not increased in the high risk groups, as compared with the control group.

Child, Preschool↗
PubMed1990

[Treatment of respiratory and ORL diseases with mineral waters in children].

Many questions arise when a paediatrician prescribes thermal treatment. Answers to these questions have come to light in recent literature. For paediatric indications, thermal treatment is dominated by asthma and its allergic equivalents. In such cases, sodium chloride and bicarbonated spas are used. Such indications are based on the research of the Pasteur Institute for Le Mont-Dore spa and on different modifications of intracelllular enzymes and increase of resistance to hypoxy incited by the La Bourboule spa. The waters in the spas of the Pyrenees contain sulphur, and are mainly used for the treatment of chronic or repeated ENT infections. Fundamental studies in favour of thermal treatment have only aroused indirect views. Following the enquiry made by the French National Health Service on 3,000 patients over a period of 3 years from 1983, it was found that this treatment reduces medical consumption, doctor's visits and hospital care in many cases. However no double-blind research could be performed despite the desire of several spas. These spas improve either the quality of the final product or the strict hygiene level in the thermal installations, and also the sanitary educational measures associated with thermal treatment.

Child↗
PubMed1990

[Non-traumatic circumscribed myositis ossificans in the femoral region].

The authors report the main clinical and radiographic aspects of non-traumatic circumscribed myositis ossificans in a 12 year-old child. These observations provide useful information for making a diagnosis. CT scan showed the presence of two distinct areas, a lucent central area and a dense outer area whose appearance suggest the presence of calcium. The main differential diagnosis concerned tumors in the soft bone tissue which necessitated regular clinical and paraclinical follow-up.

Child↗
PubMed1988

Isolated familial adrenocorticotropin deficiency: prenatal diagnosis by maternal plasma estriol assay.

We report on a brother and sister with adrenal insufficiency due to isolated adrenocorticotropin hormone deficiency discovered in the neonatal period. The first-born, a male infant, died; pathological findings suggested bilateral adrenal hypoplasia transmitted as an autosomal recessive trait. Plasma estriol levels were assayed during the mother's next pregnancy. The prenatal diagnosis allowed immediate and effective management of the second affected child. The supplementary evidence from the endocrine findings, unavailable on her brother, enabled us to make a diagnosis of isolated central ACTH deficiency. As the defect was found in infants of both sexes in the same family, it is in all likelihood transmitted as an autosomal recessive trait. We consider it important for genetic counselling to perform autopsies on all newborn infants whose death has no apparent cause. Maternal plasma estriol assays during pregnancy can help diagnose fetal adrenal insufficiency, whether the defect is central or adrenal.

Adrenal Insufficiency↗
PubMed1987

[Defect in pulmonary growth. Comparative study of 3 diagnostic criteria].

A systematic analysis was made of the autopsies of 74 newborns and fetuses (49 pathological cases and 25 controls) to detect defects in pulmonary growth. Radial alveolar count (RAC) and histological study were made in each case, as well as measurement of the ratio of pulmonary weight to total body weight (R). The ratio is of interest when lower than 0.012, but has no value if there is an intercurrent pathology. RAC decreases in pulmonary hypoplasia, but is not an entirely reliable indication since there is evolution of the values as pregnancy advances and a greater dispersion of results the earlier the gestational age. Histology disclosed an excess of bronchi, including distal bronchi, some of which exhibited delay in the differentiation of the distal aerian channel. The analysis of any two of the three above will enable diagnosis of pulmonary hypoplasia.

Body Weight↗