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Biomedical subjects

A Labbe

Publications and source records attributed to A Labbe.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Ventilation using jet-ventilation during fiber-optic bronchoscopy in children under 5 years old. Apropos of 100 case reports].

The authors report an original procedure for respiratory assistance during flexible bronchoscopy in infants and toddlers. The injector is directly connected with the operating channel of the bronchoscope. Ventilation parameters are pre-regulated before introducing the fiberscope into the respiratory tree. Insufflation volumes are restricted to 5 ml/kg at the tip of the bronchoscope, on a basis of 40 to 60 cycles per minute, according to children's age. A venturi effect may occur as discrepancy between bronchi and the size of the fiberscope does exist. For evaluating this effect, gas flow is measured through tracheal tubes selected in accordance to the size of the respiratory tree of the infant. This evaluation demonstrates that tidal volumes are comprised within 5 and 10 ml/kg. The procedure of jet-ventilation was performed on 100 infants under general anaesthesia with curarization. Baro-traumatic accidents did not occur, despite poor physical conditions in many cases. The procedure was safe for the infants and convenient for the physicians. In this way, it could be recommended for flexible bronchoscopy in infants and toddlers with poor condition or when excessive duration of the examination could be required (diagnostic or therapeutic procedures associated).

Anesthesia, General↗
PubMed1983

Spontaneously acquired factor VIII inhibitor in a non-haemophiliac child.

A three-year-old girl who had for two months suffered bruising after minimal injury was admitted because of diffuse ecchymoses and a large haematoma hindering elbow movement. These symptoms were attributable to the development of antifactor VIII inhibitor. No definite etiology was evident despite repeated immunological investigation. Although the inhibitor still persisted at high levels after two years, no further haemorrhage occurred, excepted haematomas three months after the onset of symptoms, in association with mumps.

Antibodies↗
PubMed1983

[Inverted polypoid hamartoma of the rectum in children].

Rectal tumors are rare in childhood. The description of both hamartomatous inverted polyps of the rectum and polymalformative syndrome in the same adolescent, gives the opportunity to remind the manifestations of this unusual tumor and to bring an additional argument to the Schannon Allen's malformative theory.

Child↗
PubMed1982

[Ciliary immotility syndrome without situs inversus in 2 children].

The authors report two cases of immotile cilia syndrome occurring in two children without situs inversus. The two boys, 3 and 7 years old, had bronchiectasis, chronic sinusitis and recurrent upper airway infections. In the siblings, we found Kartagener's syndrome (sister of the first boy, and two sibs of the second). The diagnosis in the 2 cases was performed by study of ciliary motion in bronchial brushing. Ultrastructural examination of biopsies from bronchial mucosa showed specific defects of the axoneme.

Adolescent↗
PubMed1982

[Familial lymphohistiocytosis. Anatomopathological study of 2 cases detected neonatally].

Two brothers presented with hemophagocytic reticulosis with neonatal onset. Early clinical and biological symptoms included pallor, hepatosplenomegaly and anemia, thrombocytopenia. Evolution was lethal in both cases, at 5 months and 13 days of age, respectively. Diagnosis was confirmed in both by the pathologic findings: diffuse lymphohistiocytic cellular proliferation with hemophagocytosis and atrophy of the lymphoid tissue. The diagnostic difficulties of this disease in the neonatal period are emphasized.

Humans↗
PubMed1980

[A syndrome of congenital diabetes with disordered epiphyseal growth with autosomal recessive inheritance (author's transl)].

A child is described with insulin dependent diabetes of neonatal onset and a disorder of endochondral growth. Radiological and histological bone appearances differ from those observed in other types of chondrodysplasia. The association of diabetes and chondrodysplasia is not likely to occur by chance but is probably a genuine clinical entity. The condition is probably inherited as a autosomal recessive and its possible pathogenesis is discussed.

Child↗
PubMedDate not supplied

Atopy parameters in asthmatic infants.

We evaluated various atopy parameters in 44 asthmatic infants aged 1-3 years: nonspecific parameters (total IgE and eosinophilia), and specific parameters relative to 21 allergens (specific IgE and skin tests), together with tests of leukotriene release by blood leukocytes (cellular allergen stimulation test; CAST) in the presence of a mixture of 21 allergens. Thus far 17 infants have displayed no sign of atopy, but 27 met at least one criterion. Eight met nonspecific criteria, and the others single or multiple criteria. Of the 21 allergens, 20 gave rise to at least one sensitization in this population. The specific IgE was more frequently positive than the skin tests. Dissociations between the two types of specific tests were practically systematic. Different phenotypes based on the chosen parameters were individualized, demonstrating heterogeneity in the expression of atopy in these young infants. The polyvalent CAST was positive only when other criteria of atopy were also positive (specific IgE and/or skin tests), and the range of intensity of the responses obtained supports reactivity rather than sensitization.

Asthma↗
PubMedDate not supplied

[Respiratory manifestations of alpha 1-antitrypsin deficiency in children. Clinical, biological and respiratory function study in 132 cases].

Clinical, biologic and respiratory functional data from 132 children with alpha 1-antitrypsin (AAT) deficiency were analysed. There were 52 girls and 80 boys. The phenotypes Pi were MZ in 72 cases, S in 32 cases, SZ in 6 cases, M null in 2 cases, S null in 1 case and other Pi in 19 cases. Mean serum AAT level was 147 +/- 40 mg/100 ml. Fifty-four children presented with upper respiratory tract infections, 61 with allergic respiratory symptoms and 5 with cystic fibrosis. Respiratory function tests showed minor abnormalities: decreased FEV1/VC (77%), increased Raw (218%), trapped gas was present (44%) and Vmax 25 (57%) decreased. Finally Technetium 99 lung perfusion scan was abnormal in 9 of 15 studied cases. It is suggested that AAT deficiency may predispose to developing chronic obstructive lung disease in childhood.

Adolescent↗
PubMedDate not supplied

[Short-term outcome of infants hospitalized for an attack of acute bronchiolitis].

The authors report the clinical, biological, radiological findings of 109 infants hospitalised for acute bronchiolitis. A prospective study was possible in 74 of them with an average of follow up of 18 months. After the admission, 31% were asymptomatic, 56% suffered at least one or several episode of wheezing, 13% have recurrent or chronic bronchopulmonary symptoms including cough and airway obstruction. Three points appeared determinant to predict recurrent wheezing: the rate of IgE, a familial history of atopy, and radiological pulmonary hyperexpansion. There was no statistic difference of evolution between the infants with wheezing at the admission and the others. The main prospective studies were analysed for discussion of the prognostic problems.

Acute Disease↗
PubMedDate not supplied

[Treatment of acute bronchiolitis in infants by oral suspension theophylline. Double-blind study in 62 children].

The present study reviews 62 children who where admitted to the department of pediatrics for acute bronchiolitis. We adopted the following therapeutic protocol: treatments were applied randomly and we administered a fast action theophylline solution (Theophylline Bruneau R) or a placebo solution every six hours by oral route or stomach probe at 10 mg/kg between 2 and 6 months, 12 mg/kg between 6 and 12 months and 16 mg/kg between 12 and 24 months. Evaluations of theophylline levels were systematically carried out (immunoenzymatic method) for every infant on day 1, day 3, and day 4 two hours after morning administration and the results studied to see if any changes were necessary. This treatment was well tolerated. Statistical analysis was performed before removal of blind. The homogeneity of the two groups was respected if we considered ages (placebo group: 7.1 months +/- 1.0, theophylline group: 5.6 months +/- 0.6), the initial seriousness as evidenced by hypoxemia (placebo group 61 +/- 2 Torr, theophylline group: 58 +/- 3 Torr) hypercapnia (placebo group: 37.8 +/- 1.0, theophylline group: 35.5 +/- 2) and chest retractions.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗