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Biomedical subjects

A Labib

Publications and source records attributed to A Labib.

33 records · Page 2Linked to original sources
PubMed1985

[Cancer of the anal canal. Results of the treatment of a series of 195 cases].

Between 1968 and 1982, 195 patients with invasive anal canal carcinoma were treated at Institut Curie (Paris, France). There were 168 females and 27 males --sex-ratio: 5.7/1, mean age: 67 +/- 11 yrs. (range: 38-85 yrs.). The initial size of the tumors was analyzed according to the circumferential invasion of the anal canal. The tumor involved 1/4 of the circumference in 49 cases, 1/2 of the circumference in 108 cases, 3/4 of the circumference in 22 cases and the whole circumference in 16 cases. Pathological examination revealed 20 cloacogenic carcinomas and 175 squamous carcinomas. All patients received radiotherapy as initial treatment and none received chemotherapy as a curative procedure. Eight patients received only palliative treatment. Twenty-seven patients were operated on because the response of the tumor to irradiation was partial or incomplete. One hundred and sixty patients received the full course of irradiation with a complete response. Among the latter, 100 patients were alive NED with a normal anal function with at least a 2-year follow-up. Local recurrences (n = 42) underwent salvage surgery in 50 p. 100 of the cases with a 3-year survival over 50 p. 100. Actuarial survival of the 195 patients was 68.5 p. 100 at 3 years and 58 p. 100 at 5 years. Survival was highly related to the initial size of the tumor and to the presence of positive inguinal nodes (p less than 0.0002). The histologic type was not related to the response to radiotherapy, nor to local recurrence or to survival.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Incidence of anterior pituitary deficiency after radiotherapy at an early age: study in retinoblastoma.

Thirty-one patients treated for retinoblastoma in the first few years (3 months to 3 years and 6 months) of life were studied 2 to 15 years later. Radiotherapy delivered 1 300 to 6 500 rads to the hypothalamo-pituitary area. Growth deficiency was documented in 30% of all cases. Other pituitary deficiencies were the exception. The critical dose for GH insufficiency is between 2 000 and 3 000 rads, as in older children or adults. Our study does not support the hypothesis that the hypothalamo-pituitary area is more sensitive to radiation at an early age. Furthermore, conservative therapy of retinoblastoma leads to double lateral irradiation and will increase the number of GH deficient children after retinoblastoma.

Adolescent↗
PubMed1983

[Treatment of primary lesions in cancer of the mobile portion of the tongue. Experience of the Curie Institute (1959-1972)].

Six hundred and two patients were treated for carcinomas of the mobile portion of the tongue between 1959 and 1972. 16% were classified T1; 48% were classified T2; 36% were classified T3. 64% had no clinical signs of lymph node spread (NO). In the majority of cases the treatment of the primary lesion consisted of radium implantation, either alone or in association with external radiotherapy. Lymph nodes were treated chiefly by surgery. The absolute and determined survival at 5 years was 36% and 48%. Determined survival for lesions classified T1, T2 and T3 was respectively 80%, 56% and 25%. 70% of recurrences occurred during the first year. 13% of the patients who developed a tumour recurrence are living at 5 years. 33% of patients undergoing secondary surgery for recurrence were living at 5 years. 2% of patients developed necroses which were treated surgically.

Combined Modality Therapy↗
PubMedDate not supplied

[A prospective study of chronic radiation lesions of the small intestine after radiotherapy of gynecologic cancer].

A prospective study was made of 80 patients with a history of gynecological malignancy, and who had received radiotherapy 2 to 5 years previously in the same centre, with the aim of determining the incidence of lesions of the small intestine after pelvic radiotherapy. Various moderate gastrointestinal symptoms were seen in 33 patients and incapacitating diarrhea in 2. Thirty-seven patients underwent gastrointestinal investigations. The great majority had a good nutritional status and normal laboratory results. Fecal losses on a normal oral diet and alpha-1-antitrypsin clearance were most often normal (3 cases of steatorrhea, 8 of creatorrhea). Small bowel barium studies revealed minor abnormalities of folds in 5 cases. There was no correlation between clinical symptomatology and the existence of laboratory and radiological abnormalities. This study shows the usual good tolerance of pelvic radiotherapy by the small intestine, at least in the mid-term. Routine investigations seeking sub-clinical intestinal lesions do not appear to be justified in patients who have undergone pelvic radiotherapy.

Adult↗