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A Lage

Publications and source records attributed to A Lage.

44 records · Page 3Linked to original sources
PubMed1982

Clinical factors related to the presence of estrogen receptors in breast cancer: a prognostic stratification analysis.

The techniques used for determination of hormone receptors have provided a biochemical basis to the concept of hormone-dependence in breast cancer. By medical experience clinical factors were established for determination of hormonal treatment in breast tumors. The criteria used need now to be re-evaluated in terms of hormone receptor contents. We analysed a group of 155 patients with histologically confirmed breast carcinoma in which estradiol receptor determination was performed. Of these tumors 54% had more than 10 fmol of estradiol per mg protein. Menopause, advanced age, late first childbirth, obesity, early menopause and nuliparity were associated, in that order, with the presence of estrogen receptors in breast tumors. Prognostic stratification analysis brought out polar groups of estrogen receptor contents. Young, premenopausal women with children had only 16% estrogen receptor-positive tumors. Postmenopausal women, either without children or with late first childbirth had as much as 81% of estrogen receptor containing tumors. Clinical variables related to the presence of estrogen receptor positive tumors in the breast cancer population were coincident to risk factors for breast cancer in the healthy population. Possible implications of this coincidences are discussed.

Adult↗
PubMed1979

Acid hydrolases in the extracellular medium of Ehrlich ascites tumor cells.

The hydrolytic activities released to the extracellular medium by tumor cells could be related to the fundamental mechanisms of invasion and metastasis. This paper deals with a study of the extracellular release of several enzymatic activities by Ehrlich ascites tumor (EAT) cells maintained in vitro. The activities of acid hydrolases increase during the first 30 minutes of in vitro incubation to levels significantly higher than those of cytoplasmic enzymes. The presented results are consistent with the hypothesis of the existence of a mechanism in these cells for the specific release of lysosomal contents.

Acetylglucosaminidase↗
PubMed1978

Effect of proteinase inhibitor in experimental tumors.

Aprotinin, a wide range proteinase inhibitor, was given alone to tumor-bearing mice and life span and several tumor growth parameters were recordered. Aprotinin showed anti-tumor effects in Hepatoma 22 and Lewis lung carcinoma, remaining ineffective in Sarcoma 37, Leukemia L1210 and Ehrlich ascitic carcinoma.

Animals↗
PubMedDate not supplied

Biodistribution of radioactive epidermal growth factor in normal and tumor bearing mice.

The biodistribution of iodinated epidermal growth factor in normal and tumor bearing mice was analyzed. The uptake of epidermal growth factor was high in the liver, skin and submaxillary gland, which all have detected receptors for the growth factor. Organs, such as lung, heart, spleen, intestine, bone and central nervous system, which lack the receptor, did not retain the growth factor. In tumor bearing mice, the growth factor accumulated in receptor positive tumors, but to a lesser extent than in the liver. This finding will probably prevent the use of epidermal growth factor as a carrier for radionuclides for a therapeutic purpose.

Animals↗
PubMedDate not supplied

Receptors for epidermal growth factor and estrogen as predictors of relapse in patients with mammary carcinoma.

Analysis of the receptors for estradiol and epidermal growth factor was performed in tumors from 225 breast cancer patients. The tumor cell content of both receptors was independent of clinical stage and lymph node status. There was an inverse correlation between the epidermal growth factor receptor and the estradiol receptor. Either the presence of the epidermal growth factor receptor or the lack of the estradiol receptor was related to a high relapse rate. A combination of these two receptors leads to an increased prognostic predictive capacity. Patients whose tumors contain both the estradiol receptor and epidermal growth factor receptor had a relapse rate similar to those whose tumors were estradiol receptor poor, and are thus high risk patients. Patients whose tumors contain the estradiol receptor and lack the epidermal growth factor receptor belong to a good prognosis group.

Carcinoma↗