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A Lagrou

Publications and source records attributed to A Lagrou.

80 records · Page 5Linked to original sources

[Pathological and biochemical studies on a neonatal case of argininosuccinic aciduria (author's transl)].

A newborn infant affected by argininosuccinic aciduria was treated with a hypoproteinaemic diet and survived up to the age of three months. Post mortem biochemical studies have confirmed the absence of argininosuccinase activity in kidney, liver and brain and a marked storage of argininosuccinic acid in the brain. The histological study of the central nervous system shows no Alzheimer type II cells; there is neither demyelination nor spongiosis. Such results are totally different from those recorded in untreated cases; they represent very likely the effects of the diet which has controlled the hyperammoniaemia and prevented a deficiency of arginine.

Amino Acid Metabolism, Inborn Errors↗