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Biomedical subjects

A Lahdensuo

Publications and source records attributed to A Lahdensuo.

48 records · Page 3Linked to original sources
PubMed1979

Non-specific reactions caused by diluents containing glycerol in nasal and bronchial challenge tests.

Sixty-one patients hospitalized because of asthma and/or allergic rhinitis were given nasal and bronchial challenge tests with diluents containing glycerol. 62% of the patients with rhinitis and 37% of those with asthma gave positive reactions. Glycerol should therefore not be used in allergen extracts which are meant for challenge tests. The non-specific effect of glycerol seems to be cumulative with increasing dose.

Administration, Intranasal↗
PubMed1978

The efficacy of oral theophylline and the combination of theophylline + hydroxyzine in chronic bronchial asthma.

The efficacy of 265 mg theophylline (150 mg of the theophylline being slow-release) and the combination of 265 mg theophylline + 7.5 mg hydroxyzine hydrochloride were compared in a double-blind cross-over placebo-controlled study in 12 patients with chronic reversible bronchial asthma. The patients took their drugs at 7.00 a.m., 1.00 p.m. and 7.00 p.m. During the trial the patients measured their peak expiratory flow (PEF) every day at 7.00 a.m., 10.00 a.m. and 9.30 p.m. The frequency and severity of symptoms and side-effects as well as the auxiliary use of isoprenaline inhalations were also recorded. The trial involved three three-day periods. Both oral theophylline and the combination of theophylline + hydroxyzine caused significant improvements in PEF in all measurement times. The PEF-level was higher when the combination was used than with plain theophylline, though the difference was not significant. Only the combination of theophylline + hydroxyzine had a significant effect on the symptoms, and the use of additional isoprenaline inhalations was also reduced during the combination period. Side-effects were minimal. Circadian variation of bronchial obstruction was seen in all these patients.

Administration, Oral↗
PubMed1977

Comparison of salbutamol and ephedrine in oral bronchodilator combinations with theophylline and hydroxyzine: their effects on asthmatics.

The efficacies of three antiasthamatic bronchodilator combinations were compared using data obtained from sixteen patients. During the trial the patients measured their peak expiratory flow (PEF) every day at 7.00 a.m., 10.00 a.m. and 9.30 pm. Six patients also measured their PEF at 1.30 a.m. The frequency and severity of symptoms and side-effects as well as the auxiliary use of isoprenaline inhalations were also recorded. This double-blind cross-over trial consisted of five four-day periods including three periods with different drug combinations and two placebo periods. By increasing the sympathomimetic activity of the basic oral drug combination of theophylline and hydroxyzine with salbutamol or ephedrine the therapeutic effect of the combination was also increased although not statistically significantly. All combinations tested differed significantly from placebo in their effect. Harmful side-effects increased in proportion to the potency of the sympathomimetic drug used in the combination; they were minimal during treatment with the basic theophylline-hydroxyzine combination. Circadian variation of bronchial obstruction was a constant phenomenon in all asthmatics participating in this trial.

Administration, Oral↗
PubMed1976

The efficacy, as modified by the circadian rhythm of salbutamol administered by different routes.

Fourteen asthmatic outpatients participated in a total of 16 trials with salbutamol administered by different routes. Drug dosage was one 4-mg tablet, of two inhalations of 100 mug of salbutamol aerosol or a combination of both, four times daily. During the trial the patients measured their peak expiratory flow (PEF) every day at 1.00 a.m., 7.00 a.m., 10.00 a.m. and 9.30 p.m. The frequency and severity of symptoms and side effects as well as the auxiliary use of isoprenaline inhalation were also recorded. A clear-cut circadian rhythm in bronchial obstruction was observed during both active drug and placebo periods. PEF values during all active periods differed significantly from those during placebo periods at 3 and 2.5 h after drug intake (at 10.00 a.m. and 9.30 p.m.). Moreover, a distinction between the effects of the various active drug forms was possible at 10.00 a.m., salbutamol tablets and the combination of salbutamol tablets and aerosols being then superior to aerosol treatment alone. At night and in the early morning PEF values were generally lower than during the day owing to the circadian rhythm, and bronchodilator response to drugs at these times was also less pronounced. Isoprenaline consumption was highest during placebo periods and lowest during periods of combined active treatment. No serious side effects were seen. Cumulative evidence has shown that this kind of study with outpatients is suitable for comparing the clinical effects of bronchodilator drugs.

Administration, Oral↗
PubMed1976

Lymphographical findings in disseminated tuberculosis without radiological lung manifestations.

Lymphographical findings are presented in three patients with verified tuberculosis. The diagnosis of tuberculosis was difficult in these patients because there were no actual changes in chest radiographs and the clinical findings were generally nonspecific. In each patient, lymphographic changes in lumbar lymph nodes were established. These changes corresponded to those described in the literature in connection with tuberculosis. Thus, the lymphographical findings can here be considered to be a further criterion for the diagnosis of tuberculosis. Lymphographical follow-up also proved beneficial in the follow-up of treatment results in one patient. Suspected tuberculosis, in which local findings cannot be made available by other means, can be regarded as one of the indications for a lymphography.

Adult↗