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A Lakos

Publications and source records attributed to A Lakos.

At least 19 recordsLinked to original sources
PubMed2004

Guidelines for the diagnosis of tick-borne bacterial diseases in Europe.

Ticks are obligate haematophagous acarines that parasitise every class of vertebrate (including man) and have a worldwide distribution. An increasing awareness of tick-borne diseases among clinicians and scientific researchers has led to the recent description of a number of emerging tick-borne bacterial diseases. Since the identification of Borrelia burgdorferi as the agent of Lyme disease in 1982, 11 tick-borne human bacterial pathogens have been described in Europe. Aetiological diagnosis of tick-transmitted diseases is often difficult and relies on specialised laboratories using very specific tools. Interpretation of laboratory data is very important in order to establish the diagnosis. These guidelines aim to help clinicians and microbiologists in diagnosing infection transmitted by tick bites and to provide the scientific and medical community with a better understanding of these infectious diseases.

Animals↗
PubMed1999

[Effect of an antibiotic combination on the propagation of Borrelia burgdorferi, causative agent of Lyme disease].

The effects of combined antibiotics (pefloxacin-doxycycline and pefloxacin-ceftriaxone) were tested on the most prevalent European Lyme spirochete species, Borrelia garinii by checkerboard dilution. The influence was judged both microscopically and by the measurement of the pH of the culture medium on the 5th day after inoculation. Borreliae propagated quite well at the concentration of 4 mg/l pefloxacin but the motility and the metabolism of the spirochete injured. Neither synergetic nor additive effect of the combination could be registered. Surprisingly, the pefloxacin at a concentration less than 4 mg/l activated both the propagation and the metabolism of borreliae, showing a clear antagonistic effect with doxycycline and ceftriaxone. Unless well-controlled animal model will prove the contrary, quinolones neither alone nor in combination should be used in Lyme borreliosis.

Anti-Infective Agents↗
PubMed1997

[TIBOLA--a new tick-borne infection].

Twenty-seven cases of a tick-transmitted infection with similar symptoms were seen by the author in the last 14 months. These symptoms do not fit into the known tick-borne infections. The bite caused by a "strikingly big" engorged tick was almost uniformly located on the occipital scalp region. The infection occurred most commonly in young children: the larger half of the patients were less than 10 years of age. The main symptom, presented in all patients, was the enlargement of painful lymph nodes in the region of the tick bite, causing us to name the infection Tick-BOrne LymphAdenopathy ("TIBOLA"). The other major feature, presented more than a half of the cases, was a herpes-like eschar 0.5-3 cm in diameter at the site of the tick bite. The eruption could be surrounded by a circular erythema (6 cases). After healing of the eruption, alopecia remained at the site. The time from the bite to the first symptom varied between 1-30 (mean 8) days. Doxycyclin seemed to shorten the disease. The infection seemed benign since only 4 patients had high fever, while 3 patients had a low grade fever (37-38 degrees C). General symptoms lasted for 3-12 months. Contrary to Lyme borreliosis, which is highly distributed all over in Hungary, the new tick-transmitted infection seems geographically more restricted, with almost all of the patient reporting that the tick bite occurred in a 120 km wide and 200 km long region along the banks of the Danube. Most probably, the disease is caused by a rickettsia infection which is still needed to be proven.

Humans↗
PubMed1992

CSF findings in Lyme meningitis.

The results of cerebrospinal fluid examination in 59 cases of meningitis caused by Borrelia burgdorferi were analysed and compared with 73 non-Lyme meningitis cases. There was no statistically significant difference in the median cell count of 160 x 10(6)/l in the Lyme meningitis patients and the 150 x 10(6)/l in the non-Lyme cases. The protein level was elevated in both patients groups to 0.9 g/l and 0.8 g/l, respectively. The glucose level of 2.9 mmol/l (1.0-6.1) was, however, significantly (P = 0.005) lower in Lyme meningitis than the 3.3 mmol/l (1.6-5.4) in the non-Lyme cases. The most important observation of the study was the finding of a combination of pleocytosis, elevated protein (greater than 0.6 g/l) and low glucose levels (less than 2.1 mmol/l) (considered to be pathognostic for tuberculous meningitis) in six of 59 cases of Lyme meningitis.

Animals↗
PubMed1991

[First isolation of Borrelia burgdorferi (Lyme spirochaeta) from ticks in Hungary].

31 field collected Ixodes ricinus adult ticks were investigated for the Lyme-disease spirochete. 5/31 Ixodes ricinus contained Borrelia burgdorferi. The spirochete was successfully cultivated in four cases, and they were found in two ticks by immunofluorescence technique and dark field microscopy, as well. Two of the isolated strains were tested by Western blot. The antigen pattern in both strains showed marked bands in 41 and 60 kD antigen, but only a week band appeared at 32 kD, with the lack of the OspB. The mechanism of infection and the way of prevention is discussed.

Animals↗
PubMed1989

[Atrioventricular block caused by tick bite--Lyme's carditis].

The authors present the case of a 44-year-old patient who was admitted to the hospital because of AV block of degree III. Six weeks earlier a tick was removed from the left foot of the patient. Two weeks later an erythema of 8 cm in diameter, spreading peripherally as well as painful inguinal lymphadenitis developed at the site of the bite with transient arthralgia and myalgia in the region of the waist and left lower limb. After the temporary use of pacemaker, steroid and atropine therapy applied because of the pronounced bradycardia the block became of degree I on the 4th day however negative T-waves appeared in leads III, aVF, V3. By the 14th day the AV time returned to normal and the pathological signs of repolarization disappeared. Serological examinations revealed increased Borrelia burgdorferi antibody level. Lyme's carditis may be prevented by starting the antibiotic therapy at the time of the chronic erythema migrans. Upon medication the patient may recover from the carditis without remaining symptoms.

Adult↗
PubMed1989

Temporary pacing in complete heart block due to Lyme disease: a case report.

The authors present the case of a 44-year-old man who was admitted with complete heart block and signs of severe bradycardia. After steroid administration and temporary pacemaker treatment the complete heart block resolved. During this therapy transient ST segment and T wave abnormalities occurred. The positive Borrelia burgdorferi antibody titer arrived only after therapy had been completed. This is regarded as the first case of Lyme carditis with complete heart block diagnosed in eastern Europe. Carditis resolved without antibiotic treatment and has not recurred.

Adult↗