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Biomedical subjects

A Lanza

Publications and source records attributed to A Lanza.

At least 91 records · Page 5Linked to original sources
PubMed1987

Two cases of clinical Ib stage cervix carcinoma with exclusive metastases to presacral lymph-nodes.

There is regular progression of metastases through different stations of pelvic lymph nodes as far as para-aortic lymph-nodes in 81.1% of the cases examined of cervix carcinoma. In this paper we report two cases of squamous carcinoma of the cervix with metastases limited to one presacral lymph node, while other pelvic and para-aortic lymph nodes were free. These cases are two examples of irregularity of invasion of metastases from cervix carcinoma. It is extremely rare that presacral station is single and first invaded without extension of lower lymph nodal level. Our technique of pre-sacral lamina excision in connection with the inferior bridge of para-aortic and para-caval connective tissue during para-aortic lymphadenectomy is confirmed. The fatal outcome of the first patient's case is related to such risk factors lymph nodes metastases, deep infiltration of the cervix and involvement of lower section of the uterus. The second patient was free of disease within four months from surgery.

Aged↗
PubMed1987

Lymph nodal metastases and the clinical stage of cervix carcinoma.

It has been proved that surgery is essential both for therapy and for diagnostic staging of gynaecological cancer. We have studied 131 patients who underwent pelvic and paraaortic lymphadenectomy. Out of the cases of the 1st clinical stage, the staging error was 16.4%. 10 cases were understage: 3 belonged to the 2nd surgical stage, 6 to the 3rd one and 1 to the 4th one. Out of 61 patients at the 2nd clinical stage, 44.2% were overstaged and 36.1% were understaged; in fact 16 belonged to the 3rd and 6 to the 4th surgical stage. 1 woman of the 6 belonging to the 3rd stage was at the 4th surgical stage. All 3 patients of the 4th stage had both clinical and surgical correct staging. The results show the determinant meaning of node metastases and their spreading for a correct surgical staging. According to the regular distribution of metastases, it has been shown that in 81.1% there is a regular rule while in 18.9% there is not a metastatic regular distribution. This study confirms the reliability of our surgical statement based on lymph nodal radical excision.

Female↗
PubMed1987

Primary tumor receptorial status and axillary metastases: their prognostic significance.

Data on the prognostic value of receptorial status are controversial. On the basis of our results, receptorial status has no significance as an independent role; only the number of involved nodes and hormonal therapy have this prognostic role. Free of disease survival curves according Kaplan and Meier show that there are no statistically significant differences either in patients with low neoplastic recurrences (pN0) or in those patients with high risk (pN1) among women with tumor ER+ and ER-. Among 291 pN0 patients there was no relation between receptorial status (negative from 3 to 9 fmol/mg) and results of therapy on the follow-up. Among 248 pN1 patients therapy with tamoxifen had an influence on free interval both in the group with a low receptorial status and in particular in that with high receptorial level; no effects of therapy on the ER- patients. In the group of 248 pN1 patients with high receptorial status, the therapy was more successful in the group with a medium lymph nodal risk (from 1 to 3 positive nodes) and also in the group with G1 or G2. With regard to the study of the relation between lymph nodal metastases and receptorial status, we can state that lymph nodal levels data gives the main prognostic factor of risk. Therefore lymphadenectomy involving the three lymph nodal levels appears to be the crucial point in diagnostic and therapeutic surgical strategy of breast carcinoma.

Axilla↗
PubMed1987

Surgical strategy management following lymph nodal positivity at the three levels (a retrospective and perspective study).

The purpose of this study is to evaluate the type of distribution, regular or irregular, of metastases in lymph nodes of I, II and III level. We inted also to establish if the levels of lymph nodal areas represent an evaluation index of prognostic risk more effective than other ones. The results evidenced that in 19.2% of all the classes N+ metastases were not increasing regularly from the level I to the level III. The influence of seven factors on disease free survival has been evaluated: pT, pN, number of metastatic nodes, ER+ or ER-, PgR+ or PgR-, grading, metastatic level at axillary lymph nodes. The present report points out that only the extent of tumor and lymph nodal level have a statistically significant influence on disease free survival. Comparison among disease free survival curves stage N0 with N+ at I level and with N+ at II level revealed that there is no significant difference of survival among these classes, while the comparison between the first 3 classes and N+ at III level is statistically significant.

Adult↗
PubMed1985

Primary choriocarcinoma of the fallopian tube: report of a case.

A case of the relatively rare condition of a choriocarcinoma in the fallopian tube is presented. The patient apparently recovered completely and quantitative beta hCG assay demonstrated negative results after TAHBSO and adjuvant chemotherapy. This brings the total cases reported to 77.

Adult↗
PubMed1984

[Female genital tuberculosis, a changing reality].

From 1964 to 1979 we diagnosed 185 new cases of female genital tuberculosis. We report the used diagnostic methods and the changes observed in this time relating to age distribution, subjective symptoms, previous and present specific lesions, clinical and anatomo-pathologic manifestations. We show either the therapeutic schedule, including rifampin, isoniazid and ethambutol, or the surgical treatment indications. With evolution and therapy of pulmonary manifestations, we debate the decrease in genital forms of extrapulmonary tuberculosis and, within the limits of that, the pelviperitonitis disappearance and the reduced incidence of tubal and ovarian inflammations and of genito-pelvic manifestations.

Amenorrhea↗
PubMed1983

Non-A, non-B hepatitis in Palermo, western Sicily.

Aetiological studies were carried out on 407 cases of acute viral hepatitis during two consecutive years in two general hospitals in Palermo, Sicily. Two hundred ninety-seven showed serological evidence of hepatitis A virus (HAV) infection and 73 of hepatitis B virus (HBV) infection. Of the remaining 37, two had a serologically diagnosed cytomegalovirus hepatitis, while 35 were classified as non-A, non-B (NANB) hepatitis. The frequency of the different major agents of acute viral hepatitis was notably influenced by the age of the patients, HAV being prevalent in children and HBV and NANB in adults. About one-fourth of the adult cases of sporadic, acute viral hepatitis were attributed to NANB virus(es). The acute disease appeared less severe than B hepatitis, as indicated by the duration of jaundice, peak serum bilirubin, and aminotransferase levels. No history of drug addiction or of parenteral exposure to blood or blood products was obtained from the presumed NANB hepatitis patients.

Adolescent↗
PubMed1982

[Epidemic of viral hepatitis in a mountain community of western Sicily].

Epidemiological investigations were carried out during and after a viral hepatitis A outbreak in a mountain town, Geraci Siculo, in western Sicily. Blood samples were obtained through finger prick or by venipuncture from patients, their family contacts and from healthy school children of different age groups (3 to 15 year old). Serum markers for hepatitis A (anti HAV and IgM anti HAV) and hepatitis B (HBsAg and anti HBs) were tested. All but two of 36 cases, which occurred from August through March with a peak in November and December were under 15; 33 of them, in which laboratory data were available, were due to HAV. Seroepidemiological investigations, performed in December 1979 and in May 1980, have shown a low prevalence of anti HAV antibodies: 11.5% only of the children tested were positive in the first sampling and 22% in the second one. Also prevalence of HBV markers was low, as compared with similar observations carried out previously in other different area of Western Sicily.

Adolescent↗