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Biomedical subjects

A Lasker

Publications and source records attributed to A Lasker.

6 recordsLinked to original sources
PubMed2000

Evidence of normal cerebellar control of the vestibulo-ocular reflex (VOR) in children with high-functioning autism.

The effect of "tilt-suppression" on post-rotatory vestibular nystagmus was investigated to assess the function of the caudal cerebellar vermis (lobules IX and X, or nodulus and uvula) in 13 school-age children with high-functioning autism (HFA) and 10 normal controls. Tilt-suppression of the vestibulo-ocular reflex (VOR) refers to the decreasing of the duration of post-rotatory vestibular nystagmus that occurs when the head is moved out of the plane in which it was located during the previous sustained constant-velocity rotation. The participant is rotated in a vestibular chair with the head upright and then the head is tilted forward just after the chair stops rotating. Such tilt-suppression is impaired with lesions of the cerebellar nodulus and portions of the uvula. Results show that children with HFA have normal post-rotatory nystasmus with the head upright and normal attenuation of post-rotatory nystagmus induced by head tilt. These behavioral findings suggest that lobules IX and X of the cerebellum are spared in high-functioning autism.

Adolescent↗
PubMed1995

Visual attention in Huntington's disease: the effect of cueing on saccade latencies and manual reaction times.

Studies of eye movements in patients with Huntington's disease (HD) have suggested that frontal lobe-basal ganglia structures are more involved in HD than the parietal lobes. To test this hypothesis further we compared the ability of HD patients and normal subjects to direct "covert" visual attention, using saccade latency and thumb press reaction time tasks that have been shown to be sensitive to parietal lobe dysfunction. Subjects were instructed to move their eyes or to press a button when a peripheral target was illuminated. The peripheral stimulus appeared at various intervals after the appearance of a central arrow(s) that pointed in the direction of the target (valid cue), in the opposite direction (invalid cue), or pointed simultaneously in both directions (neutral cue). For both saccade and thumb press paradigms, the difference in the latencies for trials with invalid and valid cues was the same in HD patients and normals. These findings suggest that the ability to direct visual attention is normal in HD and are compatible with the hypothesis that in HD, frontal-basal-ganglia circuits are more affected than parietal lobe pathways.

Attention↗
PubMed1982

Os trigonum syndrome in a patient with multiple epiphyseal dysplasia.

Multiple epiphyseal dysplasia (M.E.D.) is a rare, congenital, developmental condition characterized by epiphyseal abnormalities. Salient features of this condition are discussed. A case history is presented of a patient with os trigonum and coexisting M.E.D. The importance of weight reduction and control of excessive pronatory forces is emphasized in patients with M.E.D., thus reducing chronic microtrauma to foot structures.

Adult↗