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Biomedical subjects

A Lasser

Publications and source records attributed to A Lasser.

At least 19 recordsLinked to original sources
PubMed1998

Intraplaque verapamil injection for treatment of Peyronie's disease.

We report our findings on the effects of intraplaque injection of verapamil for the treatment of Peyronie's disease. We followed 11 men with Peyronie's disease in a nonrandomized constant dose study. During our study, four men received testosterone supplementation; five received vitamin E and/or potassium aminobenzoate (potaba) concurrent with verapamil; two received injections of verapamil only. Plaque size decreased significantly in 7 of 11 patients (55%); softening occurred in 6 (55%); 4 of 8 patients (50%) had decreased curvature. Deformities and symptoms did not recur in any patients who reported improvement. Three of 11 (27%) patients failed treatment and elected to undergo surgical correction. All four (100%) of our study participants with pain had complete resolution after intraplaque verapamil injection compared with Levine et al's 91%. We have demonstrated that intraplaque verapamil injection is a promising treatment for Peyronie's disease in that it may circumvent surgical intervention and may be used with concurrent therapies.

Adult↗
PubMed1983

Diffuse histiocytosis of the spleen and idiopathic thrombocytopenic purpura (ITP): histochemical and ultrastructural studies.

A case of ITP where the spleen was infiltrated diffusely and extensively by foamy macrophages is described. Among these macrophages were also clusters of cells with the morphologic and tinctorial characteristics of ceroid or "sea-blue" histiocytes. The ultrastructural characteristics of the foamy and ceroid histiocytes are described. Transition of ceroid cells into foamy macrophages is demonstrated, and intermediate forms were observed. It is postulated that the ceroid or sea-blue histiocytes are macrophages that contain platelets at an early stage of digestion, and when the phagocytosis of these platelets is completed, the macrophages become foamy. Therefore, it is suggested that the foamy cells and ceroid or sea-blue histiocytes seen in the spleen in cases of ITP are macrophages that have ingested and metabolized the abnormal platelets.

Aged↗
PubMed1982

Intraskeletal myofiber metastasis of breast carcinoma.

The authors report a case of chest skeletal muscle involvement by recurrent adenocarcinoma of the breast, in which individual myofibers were invaded by breast carcinoma cells. This unusual type of skeletal muscle involvement is especially interesting because it is known that the sarcolemma of skeletal myofibers is very resistant to enzymatic, mechanical, and chemical breakage.

Adenocarcinoma↗
PubMed1977

Adenomyoma of the stomach.

Two cases of adenomyoma of the stomach and a review of previous reports in the literature are presented. Adenomyoma is a benign lesion of the pylorus of the stomach composed of smooth muscle, cysts, and glandular structures lined by all columnar epithelium, Brunner's glands, and sometimes pancreatic tissue. The histopathological and radiological characteristics of this lesion are discussed.

Adult↗
PubMed1977

Epithelial (inverted) papilloma: a correlated radiological--histological study.

The radiological and pathological features in 14 cases of epithelial papilloma are described. The typical radiological findings are a mass in the nares and sinus opacification, usually on the same side. Occasionally, extension of the mass into the nasopharynx is observed. Bone destruction may be present in epithelial papilloma, possibly due to pressure erosion. In the presence of carcinoma, bone destruction may be due to direct invasion.

Adult↗
PubMed1976

Rhinosporidiosis.

A case of nasal rhinosporidiosis occurred in a 73-year-old man who has lived all his life in the United States. The lesion was treated surgically, and he remains free of disease four years later.

Aged↗
PubMed1976

Epithelial papilloma and squamous cell carcinoma of the nasal cavity and paranasal sinuses: a clinicopathological study.

Seventeen cases of intranasal epithelial tumors are reviewed. Thirteen were epithelial papillomas and four were squamous cell carcinomas associated with epithelial papillomas. In two cases followed over a 10 year period, transformation from an initial papilloma into a carcinoma was demonstrated. The histopathologic caracteristics of these lesions are described including the presence of prominent palisading and intraepithelial nesting in some tumors. The literature was reviewed for reports of carcinoma arising in previously benign epithelial papillomas. We suggest that squamous cell carcinoma may occasionally arise from a previously benign epithelial papilloma.

Adult↗
PubMed1975

Colonic neoplasms complicating ureterosigmoidostomy.

A benign reactive polyp developed at each ureteral implantation in the sigmoid colon following bilateral ureterosigmoidostomy for exstrophy of the bladder. The first polyp was discovered 23 years after the operation. The second polyp occurred 4 years later at the other ureteral orifice. Each polyp contained benign cystic glandular epithelium within the submucosa and the stalk. These submucosal cysts resembled colitis cystica profunda, except that they were confined to the pedunculated polyps. A complete review of the literature of neoplasms complicating ureterosigmoidostomy is presented. It is concluded that a benign or a malignant colonic tumor may develop at the site of the ureterocolic anastomosis many years later. Therefore, patients who undergo this operation should be followed for the rest of their lives.

Adenocarcinoma↗
PubMed1975

Ectopic liver tissue mass in the thoracic cavity.

A case is reported in which a liver tissue mass, not connected to the liver, was discovered growing in the right thoracic cavity. This mass appeared following trauma sustained to the liver several years earlier, and was noted to increase slightly in size after its initial detection. After removal of the mass, which proved to be benign hyperplastic liver tissue, the patient did well and remained free of symptoms. It is suggested that during the episode of trauma or during the ensuing surgical repair, a fragment of liver tissue was introduced into the thoracic cavity, and that this fragment eventually developed into a hyperplastic nodular liver mass.

Choristoma↗
PubMed1975

Ultrastructure of the skin in mucopolysaccharidoses. Studies performed before and after plasma infusion therapy.

Skin biopsy specimens of two siblings with Hunter syndrome and two siblings with type B Sanfilippo syndrome were examined by electron microscopy, at six-month intervals, before and after plasma infusion therapy. Electron-lucent, membrane-bound vacuoles were seen in fibroblasts, Schwann cells, and in mononuclear cells both before and after the infusions. Based on the ultrastructural, clinical, and biochemical findings, it was concluded that there was no therapeutic benefit from these plasma infusions.

Child↗