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Biomedical subjects

A Lauten

Publications and source records attributed to A Lauten.

14 recordsLinked to original sources
PubMed1987

[Acute electrophysiological effects of cardiac glycosides on sinus node function and ventricular repolarization under clinical conditions].

The influence of digoxin, digitoxin and g-strophanthin (ouabain) on the sinus node function (recovery time, sinoatrial conduction time, PP-interval) and on ventricular repolarisation (corrected QT interval and QT during permanent atrial stimulation) was studied in 101 patients (36 with sick sinus syndrome-SSS, 34 with ischaemic heart disease-IHD, and 31 control patients without cardiac disease). Digoxin caused marked prolongation of sinoatrial conduction time (in SSS and in control patients), digitoxin prolonged the PP interval (in IHD and SSS patients); digitoxin and ouabain shortened the QTcorr in SSS patients, ouabain shortened also QT during atrial pacing. The results do not point to specific indication of individual glycosides in sinus node function disturbances. Under certain clinical prerequisites, however, digitoxin can be recommended in ventricular ectopic contractions caused by prolonged or inhomogeneous repolarisation, and also the capacity of ouabain to shorten the repolarisation time deserves attention.

Cardiac Pacing, Artificial↗
PubMed1981

[Digoxin and sinus node function in the sick-sinus syndrome (author's transl)].

In 12 patients with sinus node syndrome, the influence of Digoxin on the sinus-node function was examined. After having determined the sinus-node recovery time (SNRT), the calculated sinuatrial conduction time (SACT), and the mean cycle length, 1.2 mg Digoxin were applied intravenously; 45 minutes later the above mentioned determinations were repeated. Before applying Digoxin, the mean value of the SNRT was 1665.8 +/- 1381.5 ms, after Digoxin it was 1372.1 +/- 546.1 ms; there was no statistical significance. In regard of the SACT the values were 95.9 +/- 38.6 ms before and 125.0 +/- 31.9 ms after Digoxin (p less than 0.05). The mean cycle length remained almost unchanged (841 +/- 113.2 ms before and 847 +/- 138.4 ms after Digoxin, no significance). Thus it is to be regarded as the clinical therapeutic consequence that in these patients the glycoside application in absence of syncopes or equivalents can be administered in most of the cases without previous pacemaker-implantation. In special cases, however, mainly if there are signs of greater disturbances of the sinus node function and of the SACT, electrophysical functional-analytic examination previous to the Digoxin long-term therapy should be performed.

Adult↗
PubMed1979

[Complications during long-term control of the pressure in the pulmonary artery].

It is reported on two rare complications occurring in the pulmonary catheterisation with long-term control of the pressure of the pulmonary artery. In case 1 in confluenting bronchopneumonias the formation of an abscess in the region of the point of the catheter developed, in which case by the infusion therapy with very peripheral position of the catheter local lesions are very probable. In case 2 the catheter via an atrial septum defect passed into a pulmonary vein in PCA-position. A haemorrhagic infarction of the lung developed. In the two cases after removal of the catheter and adequate therapy the pulmonary complications healed.

Adult↗
PubMed1975

[Premonitory sign of myocardial rupture].

It is reported on 14 cases in which a rupture of the myocardium occurred following a myocardial infarction. The moment of the appearance as well as anamnestic and clinical peculiarities are examined. As the only usable symptom of the rupture the symptomatology of the electromechanic dissociation must be taken into consideration. Finally it is referred to the on principle possible operative consequences of the rupture of the myocardium (oversewing or infarctetomy).

Aged↗