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A LeFaou

Publications and source records attributed to A LeFaou.

3 recordsLinked to original sources
PubMed1999

Interface between bone and nacre implants in sheep.

We have investigated the interface between bone and chronic implants of nacre in sheep. There was no foreign body reaction over the period of 10 months and the implants were not broken down. Light microscopy indicated activity within an osteoprogenitor cellular layer lining the implant, resulting in a complete sequence of new bone formation. Nacre appeared to bind directly to newly formed bone without any intervening fibrous tissue. Scanning electron microscopy and energy dispersive photon X-microanalysis showed calcium and phosphate ions lining the nacre within the osteoprogenitor tissue. These studies show a dynamic activity of the bone/nacre interface, leading to continuity between the nacre and the bone.

Animals↗
PubMedDate not supplied

A potential role for the major iron-regulated protein expressed by pathogenic Neisseria species.

Several iron-regulated proteins of Neisseria gonorrhoeae and Neisseria meningitidis have been reported. One of these, a 37,000-dalton protein is the major iron-regulated protein (MIRP) and appears to be common among all gonococcal and meningococcal isolates. This protein was purified from both N. gonorrhoeae and N. meningitidis and was found to contain approximately 1 mole of Fe /mole of protein. Sera from patients with gonococcal infections contained antibodies to the MIRP. Thus, the MIRP is expressed in vivo. The iron-binding nature of the MIRP suggests that it may have a role in iron acquisition by the pathogenic Neisseria species and, therefore, may have a function in their pathogenicity.

Amino Acid Sequence↗