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Biomedical subjects

A Legras

Publications and source records attributed to A Legras.

45 records · Page 3Linked to original sources
PubMed1990

[Outbreak of Staphylococcus aureus infections in an intensive care unit].

An outbreak of nosocomial staphylococcal infections occurred over a six months period in an intensive care unit. This outbreak was caused by a single phage type of oxacillin resistant Staphylococcus aureus (SA) which infected ten patients. Six patients had bacteremia with infected catheter, two with urinary tract infection and two patients had a pneumonia. The median SAPS was 13. Four patients died. An epidemiologic study was performed to know SA nasal carriage prevalence of patients and hospital staff. There were seven isolates of SA from 83 hospital staff and three from 20 patients, all with the same phage type 77. Hospital staff and patients colonisation with a same SA strain is a potential reservoir for epidemic nosocomial infections. Prophylactic measures are hygienic measures like handwashing, but perhaps also patients and staff selective decontamination with topical antimicrobial substances.

Cross Infection↗
PubMed1987

[Cardiovascular involvement in acromegaly. Apropos of 3 cases].

The authors report 3 cases of acromegaly diagnosed while the patients were in hospital for cardiovascular disease: arterial hypertension in two and hypertrophic myocardiopathy in all three. Coronary arteriography was normal in the 3 patients. The exercise-induced dyspnoea observed in these 3 cases was unexplained by right and left cardiac catheterization results (normal pressures, normal or increased cardiac index). It was most probably related to the myocardial hypertrophy and to abnormalities in diastolic function demonstrated by radioisotopic methods in patients 2 and 3. The degree of myocardial hypertrophy present in these 3 patients seemed to correlate with the size of the pituitary adenoma and the plasma level of growth hormone rather than with the duration or degree of arterial hypertension. After excision of the pituitary adenoma hypertension persisted in 1 case, due to associated adrenal gland hyperplasia, and subsided in the other cases. Abnormalities of diastolic function and dyspnoea are gradually regressing but left ventricular hypertrophy has not significantly decreased after 6 post-operative months.

Acromegaly↗
PubMedDate not supplied

[Pasteurella multocida pneumonia in a lupus patient: microbial identification with alveolar lavage fluid on blood culture medium].

BACKGROUND: Pasteurella multocida pneumonia mainly occurs in immunodepressed patients. Microbiological proof is difficult to obtain. CASE REPORT: A 36-year-old woman with systemic lupus erythematosus treated with cyclophosphamide and corticosteroids developed pneumonia. She was given amoxicillin-clavulanate. Bronchioalveolar lavage fluid cultures on gelose were negative but Pasteurella multocida grew on blood culture medium. DISCUSSION: Although the direct examination of bronchioalveolar lavage fluid demonstrated Gram negative coccobacilli, gelose cultures were negative, probably because of prior antibiotic therapy. The causal pathogen was only identified when BAL fluid was seeded on blood culture medium, allowing susceptibility tests and subsequent early adaptation of antibiotic therapy. This technique can be helpful in identifying the casual pathogen in microbial pneumonia.

Adult↗
PubMedDate not supplied

[Hepatic amebiasis in a metropolis. Apropos of 9 cases].

From 1981 to 1990 nine patients suffering from amebic liver abscess were under observation at the Tours hospital. Hepatic amebiasis is scarce in France. Most of the subjects have stayed in endemic areas. Most of the time patients are male adults suffering from fever and abdominal pains. In most cases the liver ultrasonography shows a single cut of the right lobe with variable and non specific aspects. Once the diagnosis has been given a metronidazole treatment must be prescribed. The diagnosis will be confirmed by serology reactions. Clinical supervision is essential. The clinical effectiveness of the treatment is spectacular. Comparatively it will take about six months until serology reactions and liver ultrasonography get back to normal. Management of hepatic amebiasis need exceptionally echo-guided percutaneous puncture or surgery.

Adult↗