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Biomedical subjects

A Lellouch

Publications and source records attributed to A Lellouch.

At least 19 recordsLinked to original sources
PubMed1989

[J.M. Charcot's (1825-1893) method].

The aim of this study is to show the various aspects of Charcot's methodology from examples provided by Charcot's publications in the field of geriatrics. The source material consists of unedited Charcot's manuscripts, stored in Charcot's library at the Salpêtrière hospital, in Paris. Mainly inspired by Müller's and Virchow's methodologic pattern, J.M. Charcot filled the gap which concerned French medicine, in the middle of the nineteenth century, when the rhythm of its discoveries decreased. Charcot substituted successfully the old Parisian 'hospital medicine' for new features of medicine initiated by German doctors. Charcot's methodology implied also a new scientific theory in medicine.

France↗
PubMed1984

[Asymptomatic severe stenosis of the left main coronary artery].

Severe stenosis (greater than 70%) of the main stem of the left coronary artery may rarely be asymptomatic. This particular clinical presentation, which has recently been highlighted, is probably commoner than had previously been thought. Though usually a chance finding, its presence should be suspected when exercise stress tests are strongly positive at low work loads; confirmed at coronary angiography, asymptomatic stenosis of the left main coronary artery is no different from symptomatic stenoses with regard to the extent and severity of the coronary lesions; they do differ, however, in that left ventricular function is preserved and may remain normal over a long period. This has therapeutic implications in that systematic surgery of first intention may not be mandatory in these cases.

Angiography↗
PubMed1981

Continuous electrocardiographic recording (Holter method) during indapamide treatment: a study of 40 cases.

In 40 hypertensive patients continuous ECG recording was done before and after 30 days treatment with indapamide 2.5 mg. There was no change in heart rate. In addition, the incidence of extrasystoles was not changed in patients in whom the ECG was normal before treatment (30 cases) or in 8 of the 10 patients who had an incidence of more than 1% extrasystoles. However, in the other 2 patients who presented with an incidence of more than 1% extrasystoles the incidence of extrasystoles rose.

Adult↗
PubMed1976

Autonomic influences and cardiac conduction in patients with sinus node disease.

18 patients with sinus bradycardia (8 SB) and tachycardia-bradycardia syndrome (10 TBS) were investigated using various vagan reflex manoeuvres, atrial pacing (AP), pharmacological tests and His bundle (HB) recordings, to assess autonomic influences, sinus node function and atrioventricular (AV) conduction. Three types of responses (R) were defined as normal (N), supernormal (SN), poor autonomic (PA). Poor reflex responses to vagal manoeuvres, performed in 12 patients, have no statistical significance. MxCSRT at AP suppression was measured in 13 patients: it was normal (less than or equal to 500 msec) in 8 and increased (from 680 to 4,200 msec) in 5 patients with appearance of junctional escapes. Moreover, AP suppression revealed a sinoatrial block (SAB) in 1 patient with normal MxCSRT. Isoprenaline, administered intravenously (3-6 mug) in 9 patients, showed 4 NR, 3 PAR und 2 SNR (unusual sinus tachycardia, 1; atrial fibrillation, 1). Atropine (0.5-1 mg), used in 15 patients, revealed 5 PAR and 1 SNR. Prostigmine (0.5 mg), used in 11 patients, induced 6 NR and 5 PAR. Lanatosid C (0.08 mg), administered in 16 patients, showed 10 NR, 5 PAR and 1 SNR. Finally, ajmaline (100 mg), given in 13 patients, revealed 5 junctional rhythms and one 2:1 SAB. HB recorded in 17 patients showed an increase of AH interval (greater than 140 msec) in 5 patients and a slight increase (60 msec) of HV interval in 2 patients. Three patients developed 2nd-degree AV block at paced rates greater than or equal to 110/min. Abnormal responses at AP suppression and reduced drug responses were noted in 5 patients suffering from Adam-Stokes attacks; a permanent pacemaker was inserted in 4 of these 5 patients. In conclusion, provocative tests, in 18 patients with SB or TBS, suggest a diffuse process disease involving the autonomic function of both sinus node and AV junction (11 patients) and the AV system (6 patients). These immediate results must be correlated with histological findings in the conduction system, as shown in one of our cases previously reported.

Adult↗
PubMed1975

[Results of 79 hepatic biopsies in untreated bacillary pleurs pulmonary tuberculosis patients].

The authors report 79 needle biopsies of the liver, using a Menghini needle, carried out as routine in untreated cases of pulmonary tuberculosis with positive sputum. Apart from the histological study, the authors carried out, in 30 cases, a bacteriological study of the liver fragment. The bacteriological and histological results are reported here in detail, then compared with those in the world literature. No significant correlation was found between the histological type of the suggestive hepatic lesions, e.g. follicular appearances or appearances of nodular küpferian hyperplasia and the radioclinical variety of pulmonary tuberculosis, e.g. parenchymatous, pleural or miliary. The authors emphasize the significance of each type of pathological lesion encountered, in particular, the appearance of nodular küpferian hyperplasia or intralobular, lymphohistiocytic islets, which seem to them remarkable by their relative frequency and their chararacter fairly suggestive of tuberculosis. In spite of the low number of pathological appearances obtained in these liver biopsies, the present study nevertheless permitted a few interesting conclusions on the blood spread of the tubercle bacillus and the significance of changes in the Küpfer system during common pulmonary tuberculosis.

Adult↗