Biomedical subjects

A Lemle

Publications and source records attributed to A Lemle.

At least 19 recordsLinked to original sources

PubMed1990

Pulmonary function changes in the acute stage of histoplasmosis, with follow-up. An analysis of eight cases.

We have studied eight patients, six children and two adults, during a microepidemic of soil- and patient-proven histoplasmosis. Pulmonary function tests were performed between the 15th and 23rd days after the onset of symptoms, and repeated between the fifth and sixth, the ninth and tenth and the 15th and 22nd months afterward. Initial abnormalities were mild in seven cases and severe in one. There was a restrictive pattern in three cases and an obstructive pattern in two. The fraction of CO extraction was reduced in five cases and the diffusing capacity for CO was reduced in five of six cases so tested. Hypoxemia was present in three cases. On follow-up, the obstructive defect had disappeared by the sixth month, the restrictive pattern by the tenth month, and the diffusing defect still remained in three cases by the end of follow-up. Hypoxemia remained only in the severe case.

Adolescent↗

PubMed1976

The defect in pulmonary gas transfer in patients with sickle cell disease.

Nine patients with sickle cell disease and without concomitant cardiopulmonary illness or acute problems were studied with lung function tests. Besides arterial hemoglobin unsaturation, found in all cases so studied, a slight decrease in PaO2 was also present. The pulmonary gas transfer defect was studied and found to be due mostly to increased right to left shunting, although uneven ventilation/perfusion relationships seem to have been a factor in a few cases. Our data clearly show that the diffusion was not implicated in the gas transfer defect. The clinical implications of this little studied and less mentioned respiratory defect are discussed. Since the defect may enhance the risk of sickling crises, it should be measured in each individual patient, for appropriate prophylactic measures. After accidents, pre and post-operatively and during acute respiratory illness, the defect should be again reevaluated. In all probability many patients will be discovered who represent a respiratory risk, and may require special immunizations, prophylactic antibiotics, professional relocation and, during emergencies, intensive respiratory care.

Adult↗

PubMed1975

Cardiopulmonary disease in Manson's schistosomiasis.

Five patients with cardiopulmonary manifestations of Manson's schistosomiasis are described. Two patients had pulmonary hypertension, two had cyanosis and one had the very rare combination of both. The results of routine pulmonary function tests--not sufficiently studied in this form of schistosomiasis--are discussed in detail. Aside from a tendency to hyperventilate, found in all cases, the only significant abnormality encountered was hypoxemia due to increased right-to-left shunt in the cyanotic patients. Although more studies are needed, the results suggest that the pulmonary lesions are mainly vascular in nature. The pathogenesis of cyanosis in this disease is briefly discussed.

Adolescent↗

PubMed1974