[Acute non-tuberculous infectious pneumopathies].
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Biomedical subjects
Publications and source records attributed to A Lepilliez.
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Employed since 1971, contra-immunoelectrophoresis is a microbiological technique now recognised as being of increasing value. Used in 37 cases of pneumococcal lung infections its diagnostic reliability was 81% the technique being of particular interest in that it enabled a positive diagnosis in lung infections previously treated by antibiotics. Though performed in only a small number of cases, this method was able to confirm the frequency of pneumococcal infections. The technique can now be considered to be well established, the production of specific anti-serums, approaching type-specificity, being possible. Fairly simple to perform, and giving rapid results (within hour) it requires a minimum of apparatus and is a standard procedure that should be employed in all microbiological medical laboratories. Of undeniable diagnostic value, it should be associated with conventional bacteriological tests, which though essential sometimes give insufficient data.
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A further case of granulomatous hypersensitivity angiitis (syndrome described by Churg and Strauss) is reported. Clinical, biological, and histological features (asthma, blood eosinophilia, necrotizing angiitis lesions, extravascular eosinophilic and granulomatous infiltrates) differentiate this affection from other necrotizing angiitis diseases, particularly from polyarteritis nodosa. Unusual features in this case were its favorable course, and the remission following combined corticoid and cyclophosphamide treatment. Diagnostic, clinical and histological criteria which distinguish Churg and Strauss's angiitis from other necrotizing angiitis affections are described, and current pathogenic hypotheses discussed.