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Biomedical subjects

A Leyhe

Publications and source records attributed to A Leyhe.

12 recordsLinked to original sources
PubMed1991

[Capillary microscopy controlled nail fold biopsy in the diagnosis of collagen disease and vasculitis].

In cases of suspected microangiopathies morphologic abnormal capillaries were identified and marked by nailfold capillary microscopy (NCM). The marked nailfold areas were precisely biopsied and the biopsies were examined by electronic-microscopy and light microscopy (HE and immune-histochemical). Histological findings well correlated with clinical and capillaroscopical findings. It is concluded that NCM-assisted nailfold biopsy helps to achieve histologic proof of microangiopathies and improves diagnostic accuracy in collagen vascular diseases and vasculitides.

Biopsy↗
PubMed1990

Transcutaneous measurement of oxygen and carbon dioxide tension (TcPO2 and TcPCO2) during treadmill exercise in patients with arterial occlusive disease (AOD)--stages I and II.

Transcutaneous oxygen and carbon dioxide tensions were measured during treadmill exercise in 30 patients with stages I and II arterial occlusive disease and 28 normal controls. Measuring sites were the dorsum of the foot and the frontal thorax. The calculated oxygen index at maximum exercise/rest (foot/thorax) differentiated with 100% sensitivity and specifity between the two groups. The oxygen index was the only parameter with a significant positive correlation with the pain-free walking distance, whereas, eg, oscillography and Doppler analysis did not correlate. Carbon dioxide tensions showed significant differences only in the recovery time between patients and normal controls.

Adult↗
PubMed1985

[Obliterating arterial angiopathy of the finger in vibration disease].

Twenty-nine patients with a clinically verified vibration syndrome after many years of work with chain saws underwent angiography of the hand and forearm. In 62-99% of the finger arteries investigated, occlusions, kinking and (more rarely) stenoses were found, preferentially on the long fingers II, III, IV and V (with decreasing incidence). Since the vibration syndrome is recognized as an occupational disease, angiographic evaluation of the degree of severity of the vascular damage appears to be of great significance in terms of industrial and insurance law, besides providing non-invasive proof of the vasospastic component of the clinical picture.

Adult↗
PubMed1979

Hemodilution (HD) in patients with ischemic skin ulcers.

In 25 patients with arterial occlusive disease in the clinical stage IV according to Fontaine a hemodilution down to an average hematocrit value of 0.31 +/- 0.02 was performed. Eighteen patients had peripheral ulcers of the lower limbs and 3 patients had ulcers of the upper ones. Four patients had tissular lesions both at the level of the feet and toes and hand and fingers. The average age of the patients was 43. Hemodilution was achieved by repeated withdrawals of approx. 500 ml blood, followed by reinfusion of the autologous plasma associated with infusion of substitutive solutions of low-molecular weight dextran to avoid hypovolemia. In all patients with peripheral ulcers of the upper limbs, with no exception, a good to a very good clinical effect was obtained ranging from extended to complete healing. The healing tendency of lesions in the feet and toe region was on the whole less marked and depended basically on the total number of vascular impediments found in one patient. The rheological and hemodynamic mechanism of the therapeutic effect of hemodilution, the preliminary criteria for indicating this therapy and its observed complications are discussed.

Adult↗